Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

Cancer statistics, 2023

(2023) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Radiation-induced senescence: therapeutic opportunities

(2023) Jae Ho Kim et al.   Radiation Oncology

Molecular mechanisms of tumor resistance to radiotherapy

(2023) Yu Wu et al.   Molecular Cancer

Cancer-Associated Fibroblast: Role in Prostate Cancer Progression to Metastatic Disease and Therapeutic Resistance

(2023) Martina Bedeschi et al.   Cells

Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

(2023) Hanxin Liu et al.   AGING CELL

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

(2022) Lei Zhang et al.   FEBS Journal

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer

(2022) Juening Kang et al.   CANCER LETTERS

Cell cycle regulation: p53-p21-RB signaling

(2022) Kurt Engeland   CELL DEATH AND DIFFERENTIATION

Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

(2022) Natalie Kudlova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins

(2022) Joakin O. Mori et al.   PROSTATE

Recent Advances in Senotherapeutics Delivery

(2022) Ji Young Choi et al.   Tissue Engineering Part B-Reviews

Senotherapeutics in Cancer and HIV

(2022) Laura Sánchez-Díaz et al.   Cells

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

(2022) Rongbin Ge et al.   npj Precision Oncology

Cellular senescence and senolytics: the path to the clinic

(2022) Selim Chaib et al.   NATURE MEDICINE

Cellular senescence: the good, the bad and the unknown

(2022) Weijun Huang et al.   Nature Reviews Nephrology

Mesenchymal stem cells and prostate cancer: A concise review of therapeutic potentials and biological aspects

(2022) Maryam Rahimi Tesiye et al.   Stem Cell Research

Molecular and pathological subtypes related to prostate cancer disparities and disease outcomes in African American and European American patients

(2022) Joakin O. Mori et al.   Frontiers in Oncology

The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy

(2022) Christopher M Heaphy et al.   Journal of Pathology Clinical Research

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

(2022) Rahul Rimal et al.   ADVANCED DRUG DELIVERY REVIEWS

Senescence-associated secretory phenotype and its impact on oral immune homeostasis

(2022) Ziqi Yue et al.   Frontiers in Immunology

Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

(2022) Jasmine S. Owen et al.   Biomolecules

Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

(2021) Sujun Chen et al.   NATURE CELL BIOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Key chemokines direct migration of immune cells in solid tumors

(2021) Karan Kohli et al.   CANCER GENE THERAPY

Senescence mechanisms and targets in the heart

(2021) Maggie S Chen et al.   CARDIOVASCULAR RESEARCH

The bone microenvironment invigorates metastatic seeds for further dissemination

(2021) Weijie Zhang et al.   CELL

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

(2021) Marco Raffaele et al.   Cell Communication and Signaling

Role of Exosomes in Prostate Cancer Metastasis

(2021) Theresa Akoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone

(2021) Andy Göbel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy

(2021) Pataje G Prasanna et al.   JNCI-Journal of the National Cancer Institute

Novel approaches to target the microenvironment of bone metastasis

(2021) Lorenz C. Hofbauer et al.   Nature Reviews Clinical Oncology

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

(2021) Katie J. Mylonas et al.   Science Translational Medicine

The Contribution of Lysosomes to DNA Replication

(2021) Joanna Maria Merchut-Maya et al.   Cells

Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy

(2021) Valerie Carpenter et al.   BIOCHEMICAL PHARMACOLOGY

Efficacy and limitations of senolysis in atherosclerosis

(2021) Abel Martin Garrido et al.   CARDIOVASCULAR RESEARCH

Fibroblasts: Origins, definitions, and functions in health and disease

(2021) Maksim V. Plikus et al.   CELL

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

(2021) Angel Cayo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senotherapeutics: Targeting senescent cells for the main age-related diseases

(2021) Virginia Boccardi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls

(2021) W Andrew Owens et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cellular senescence as a possible link between prostate diseases of the ageing male

(2021) Gaelle Fiard et al.   Nature Reviews Urology

Stromal cell interplay in prostate development, physiology, and pathological conditions

(2021) Bruno D. A. Sanches et al.   PROSTATE

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

The redox-senescence axis and its therapeutic targeting

(2021) Natalie YL. Ngoi et al.   Redox Biology

Single-cell analyses unravel cell type–specific responses to a vitamin D analog in prostatic precancerous lesions

(2021) Mohamed A. Abu el Maaty et al.   Science Advances

Immune Inflammation Pathways as Therapeutic Targets to Reduce Lethal Prostate Cancer in African American Men

(2021) Maeve Kiely et al.   Cancers

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

(2021) Yifan Tai et al.   Biomolecules

A Senescence Bystander Effect in Human Lung Fibroblasts

(2021) David W. Waters et al.   Biomedicines

Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences

(2021) Walter Rayford et al.   Communications Biology

Fibroblast heterogeneity in prostate carcinogenesis

(2021) Sathyavathi ChallaSivaKanaka et al.   CANCER LETTERS

Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy

(2021) Shihong Peng et al.   CLINICAL CANCER RESEARCH

Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?

(2021) Nicola Alessio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Survival of African-American and Caucasian men after sipuleucel-T immunotherapy: outcomes from the PROCEED registry

(2020) Oliver Sartor et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Immunotherapeutic Response in Tumors Is Affected by Microenvironmental ROS

(2020) Simon W. Hayward   CANCER RESEARCH

Tumor microenvironment complexity and therapeutic implications at a glance

(2020) Roghayyeh Baghban et al.   Cell Communication and Signaling

Oncogene-induced senescence: From biology to therapy

(2020) Haoran Zhu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

(2020) Thanakorn Pungsrinont et al.   Cell and Bioscience

The mesenchymal context in inflammation, immunity and cancer

(2020) Vasiliki Koliaraki et al.   NATURE IMMUNOLOGY

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

(2020) Francesco Bonollo et al.   Cancers

DNA Damage- But Not Enzalutamide-Induced Senescence in Prostate Cancer Promotes Senolytic Bcl-xL Inhibitor Sensitivity

(2020) Nicolas Malaquin et al.   Cells

Induction and transmission of oncogene-induced senescence

(2020) Nattaphong Rattanavirotkul et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Comparative genomics reveals distinct immune-oncologic pathways in African American men with prostate cancer

(2020) Shivanshu Awasthi et al.   CLINICAL CANCER RESEARCH

Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche

(2020) Xiaohong Peng et al.   Cell Death & Disease

Prostate Cancer Incidence and Survival, by Stage and Race/Ethnicity — United States, 2001–2017

(2020) David A. Siegel et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers

(2020) Irina Larionova et al.   Frontiers in Oncology

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Senescent cell accumulation mechanisms inferred from parabiosis

(2020) Omer Karin et al.   GeroScience

Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy

(2020) W Nathaniel Brennen et al.   Immunotherapy

Pro- and anti-tumorigenic functions of the senescence-associated secretory phenotype

(2019) Lena Lau et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Halogen-substituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists

(2019) Daniela Roell et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

The curcumin analog EF24 is a novel senolytic agent

(2019) Wen Li et al.   Aging-US

Development of a Cross-Reactive Monoclonal Antibody for Detecting the Tumor Stroma

(2019) Hallie M. Hintz et al.   BIOCONJUGATE CHEMISTRY

CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

(2019) Xing Li et al.   EXPERIMENTAL CELL RESEARCH

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

(2019) Lina Palacio et al.   AGING CELL

Inflammation-induced DNA damage, mutations and cancer

(2019) Jennifer Kay et al.   DNA REPAIR

Mesenchymal Stem Cell Migration and Tissue Repair

(2019) Fu et al.   Cells

Prostate Cancer

(2019) Aradhana Rani et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibroblasts in cancer: Defining target structures for therapeutic intervention

(2019) Maximilian Boesch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Diflunisal targets the HMGB 1/ CXCL 12 heterocomplex and blocks immune cell recruitment

(2019) Federica De Leo et al.   EMBO REPORTS

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease

(2019) John Papaconstantinou   Cells

Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

(2019) Camilla S. L. Tuttle et al.   AGING CELL

Senescent cell turnover slows with age providing an explanation for the Gompertz law

(2019) Omer Karin et al.   Nature Communications

AMPK-mediated senolytic and senostatic activity of quercetin surface functionalized Fe3O4 nanoparticles during oxidant-induced senescence in human fibroblasts

(2019) Anna Lewinska et al.   Redox Biology

Cancer-associated fibroblasts in tumor microenvironment – Accomplices in tumor malignancy

(2018) Zehuan Liao et al.   CELLULAR IMMUNOLOGY

IFNL4-ΔG allele is associated with an interferon signature in tumors and survival of African-American men with prostate cancer

(2018) Wei Tang et al.   CLINICAL CANCER RESEARCH

Sex steroids in the tumor microenvironment and prostate cancer progression

(2018) Clovis Boibessot et al.   ENDOCRINE-RELATED CANCER

Fibroblast heterogeneity: implications for human disease

(2018) Magnus D. Lynch et al.   JOURNAL OF CLINICAL INVESTIGATION

The senescent bystander effect is caused by ROS-activated NF-κB signalling

(2018) Glyn Nelson et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Interleukin-6 and prostate cancer: Current developments and unsolved questions

(2018) Zoran Culig et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

(2018) Ellen Puré et al.   ONCOGENE

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro

(2018) Helen M. Palethorpe et al.   Oncotarget

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Elevated Stromal Inflammatory Mediators Promote Prostate Cancer Progression in African American Men

(2018) Marc Gillard et al.   CANCER RESEARCH

Mesenchymal stem cells and the embryonic reawakening theory of BPH

(2018) W. Nathaniel Brennen et al.   Nature Reviews Urology

Senescence and senotherapeutics: a new field in cancer therapy

(2018) Vassilios Myrianthopoulos et al.   PHARMACOLOGY & THERAPEUTICS

Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma

(2018) Maria K. Andersen et al.   Scientific Reports

The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

(2018) Katharina Helene Susek et al.   Frontiers in Immunology

The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer

(2018) Sudha Savant et al.   Cancers

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

(2018) Timothy E. Krueger et al.   PROSTATE

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

(2018) Gervaise H. Henry et al.   Cell Reports

Histologic features of stromogenic carcinoma of the prostate (carcinomas with reactive stroma grade 3)

(2017) Andrea Diaz De Vivar et al.   HUMAN PATHOLOGY

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal stem cells: key players in cancer progression

(2017) Sarah M. Ridge et al.   Molecular Cancer

To stay young, kill zombie cells

(2017) Megan Scudellari   NATURE

Telomeres and telomerase in prostate cancer development and therapy

(2017) Mindy Kim Graham et al.   Nature Reviews Urology

The inflammatory microenvironment and microbiome in prostate cancer development

(2017) Karen S. Sfanos et al.   Nature Reviews Urology

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

(2017) W. Nathaniel Brennen et al.   Oncotarget

Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression

(2017) Yanfei Peng et al.   Oncotarget

Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance

(2017) Christine Levesque et al.   Cold Spring Harbor Perspectives in Medicine

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Biomarkers to identify and isolate senescent cells

(2016) Mantas Matjusaitis et al.   AGEING RESEARCH REVIEWS

Regulation of prostate cancer progression by the tumor microenvironment

(2016) Stephen L. Shiao et al.   CANCER LETTERS

Dietary flavonoid fisetin for cancer prevention and treatment

(2016) Rahul K. Lall et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures

(2016) W. Nathaniel Brennen et al.   PROSTATE

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay

(2016) W. Nathaniel Brennen et al.   Oncotarget

The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease

(2016) Christina J. Turner et al.   Current Osteoporosis Reports

Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans

(2016) Ken Batai et al.   Frontiers in Immunology

Mesenchymal Cell Contributions to the Stem Cell Niche

(2015) Youmna Kfoury et al.   Cell Stem Cell

Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial

(2015) Christopher M. Heaphy et al.   PROSTATE

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

(2015) Ridwana Chowdhury et al.   Oncotarget

Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk

(2014) Hua Xu et al.   Asian Pacific Journal of Cancer Prevention

Supraphysiological androgen levels induce cellular senescence in human prostate cancer cells through the Src-Akt pathway

(2014) Julia Roediger et al.   Molecular Cancer

A Natural Androgen Receptor Antagonist Induces Cellular Senescence in Prostate Cancer Cells

(2014) Wiebke Hessenkemper et al.   MOLECULAR ENDOCRINOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Inflammation and prostate cancer: the role of interleukin 6 (IL-6)

(2013) Daniel P. Nguyen et al.   BJU INTERNATIONAL

Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery

(2013) Michael P. Lisanti et al.   CELL CYCLE

Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment

(2013) W Nathaniel Brennen et al.   ENDOCRINE-RELATED CANCER

Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-β1

(2013) Justyna Mikuła-Pietrasik et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples

(2013) GIOVANNI LUCA GRAVINA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Prostate Cancer Cell Telomere Length Variability and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death

(2013) C. M. Heaphy et al.   Cancer Discovery

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Myofibroblasts

(2012) Biao Hu et al.   CURRENT OPINION IN RHEUMATOLOGY

The reactive stroma microenvironment and prostate cancer progression

(2012) David A Barron et al.   ENDOCRINE-RELATED CANCER

Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy

(2012) W. N. Brennen et al.   MOLECULAR CANCER THERAPEUTICS

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Androgen Receptor Drives Cellular Senescence

(2012) Yelena Mirochnik et al.   PLoS One

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

(2011) Ralf Hass et al.   Cell Communication and Signaling

CXCL12-CXCR4 Axis in Angiogenesis, Metastasis and Stem Cell Mobilization

(2011) S. Liekens et al.   CURRENT PHARMACEUTICAL DESIGN

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression

(2011) S. M. Welford et al.   MOLECULAR CANCER RESEARCH

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

20-Aminosteroids as a novel class of selective and complete androgen receptor antagonists and inhibitors of prostate cancer cell growth

(2010) Manolis A. Fousteris et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Genomic Alterations in Tumor Stroma

(2009) C. Eng et al.   CANCER RESEARCH

DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16INK4a Activation

(2009) Y. Kotake et al.   CANCER RESEARCH

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

(2008) T. A. Wallace et al.   CANCER RESEARCH

The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy

(2008) L.A. Begley et al.   CYTOKINE

Pilot and feasibility study of serum chemokines as markers to distinguish prostatic disease in men with low total serum PSA

(2008) Jill A. Macoska et al.   PROSTATE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

(2003) Utz Herbig et al.   AGING CELL