Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
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Title
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
Authors
Keywords
Ageing, Atherosclerosis, Cardiovascular, Heart failure, Inflammation, Remodelling, Senescence, Senolytic
Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 198, Issue -, Pages 111540
Publisher
Elsevier BV
Online
2021-07-06
DOI
10.1016/j.mad.2021.111540
References
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Note: Only part of the references are listed.- Cellular senescence evaluated by P16INK4a immunohistochemistry is a prevalent phenomenon in advanced calcific aortic valve disease
- (2021) Kei Shing Oh et al. CARDIOVASCULAR PATHOLOGY
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- (2021) Jedrzej Hoffmann et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
- (2021) Salim S. Virani et al. CIRCULATION
- The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling
- (2021) Luke Spray et al. Frontiers in Immunology
- Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity
- (2020) Maria A. Mitry et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
- (2020) Francisco Triana-Martínez et al. Cells
- Atrial myxomas arise from multipotent cardiac stem cells
- (2020) Mariangela Scalise et al. EUROPEAN HEART JOURNAL
- Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity
- (2020) Yonghan He et al. Nature Communications
- Growth differentiation factor 15 in adverse cardiac remodelling: from biomarker to causal player
- (2020) Marian Wesseling et al. ESC Heart Failure
- Targeting senescent cells to attenuate cardiovascular disease progression
- (2020) Ping Song et al. AGEING RESEARCH REVIEWS
- Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
- (2020) Laurent Grosse et al. Cell Metabolism
- Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
- (2020) Emily Dookun et al. AGING CELL
- Cardiac rupture complicating acute myocardial infarction: the clinical features from an observational study and animal experiment
- (2020) Qun Lu et al. BMC Cardiovascular Disorders
- Therapeutic Potential of Senolytics in Cardiovascular Disease
- (2020) Emily Dookun et al. CARDIOVASCULAR DRUGS AND THERAPY
- Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies
- (2020) Danlin Liu et al. CLINICAL SCIENCE
- A guide to assessing cellular senescence in vitro and in vivo
- (2020) Estela González‐Gualda et al. FEBS Journal
- Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
- (2020) Jasper Iske et al. Nature Communications
- Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure
- (2019) Jing Ye et al. MEDIATORS OF INFLAMMATION
- Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential
- (2019) Rachel Oldershaw et al. STEM CELLS AND DEVELOPMENT
- Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
- (2019) Rhys Anderson et al. EMBO JOURNAL
- Cellular Mechanisms of Aortic Aneurysm Formation
- (2019) Raymundo Alain Quintana et al. CIRCULATION RESEARCH
- Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
- (2019) Emelia J. Benjamin et al. CIRCULATION
- Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction
- (2019) Anna Walaszczyk et al. AGING CELL
- Aged-senescent cells contribute to impaired heart regeneration
- (2019) Fiona C. Lewis-McDougall et al. AGING CELL
- Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
- (2019) Daniel A. Richards et al. Scientific Reports
- Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease
- (2019) Brittany Balint et al. EBioMedicine
- Statistics on mortality following acute myocardial infarction in 842,897 Europeans
- (2019) O A Alabas et al. CARDIOVASCULAR RESEARCH
- Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
- (2019) Hubert Fleury et al. Nature Communications
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
- (2019) Stevan D Stojanović et al. EUROPEAN HEART JOURNAL
- Elevated Plasma Levels of LDL Cholesterol Promote Dissecting Thoracic Aortic Aneurysms in Angiotensin II–Induced Mice
- (2018) Hiroki Tanaka et al. ANNALS OF VASCULAR SURGERY
- Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-CellsHighlights
- (2018) Gavin David Richardson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cardiovascular, pulmonary, and metabolic toxicities complicating tyrosine kinase inhibitor therapy in chronic myeloid leukemia: Strategies for monitoring, detecting, and managing
- (2018) Bruno C. Medeiros et al. BLOOD REVIEWS
- Critical roles of inflammation in atherosclerosis
- (2018) Junji Moriya Journal of Cardiology
- Stress, cell senescence and organismal ageing
- (2018) João Pedro de Magalhães et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy
- (2018) Marco Malavolta et al. MEDIATORS OF INFLAMMATION
- ISHLT Primary Graft Dysfunction incidence, risk factors and outcome
- (2018) Sanjeet Singh Avtaar Singh et al. TRANSPLANTATION
- Exercise induces new cardiomyocyte generation in the adult mammalian heart
- (2018) Ana Vujic et al. Nature Communications
- Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations
- (2018) Marissa J. Schafer et al. Current Rheumatology Reports
- Calcific Aortic Valve Disease: a Developmental Biology Perspective
- (2018) Punashi Dutta et al. Current Cardiology Reports
- Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis
- (2018) Joel S Riley et al. EMBO JOURNAL
- Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice
- (2018) Clara Correia-Melo et al. AGING CELL
- Paradoxes of senolytics
- (2018) Mikhail V. Blagosklonny Aging-US
- Plasma interleukin 6 levels are associated with cardiac function after ST-elevation myocardial infarction
- (2018) Hilde E. Groot et al. Clinical Research in Cardiology
- Mechanisms driving the ageing heart
- (2017) Rhys Anderson et al. EXPERIMENTAL GERONTOLOGY
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists
- (2017) Margherita Neri et al. MEDIATORS OF INFLAMMATION
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- The Biological Basis for Cardiac Repair After Myocardial Infarction
- (2016) Sumanth D. Prabhu et al. CIRCULATION RESEARCH
- Pulmonary arteriovenous malformations: an uncharacterised phenotype of dyskeratosis congenita and related telomere biology disorders
- (2016) Payal P. Khincha et al. EUROPEAN RESPIRATORY JOURNAL
- Identification of Senescent Cells in the Bone Microenvironment
- (2016) Joshua N Farr et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis
- (2016) Juan M. Fernández-Alvira et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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- (2016) Kathleen Meyer et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
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- (2016) B. G. Childs et al. SCIENCE
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
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- (2016) Gavin D. Richardson Jove-Journal of Visualized Experiments
- Cellular senescence controls fibrosis in wound healing
- (2016) Joon-Il Jun et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Dynamics of Cell Generation and Turnover in the Human Heart
- (2015) Olaf Bergmann et al. CELL
- Pathophysiology of ST-segment elevation myocardial infarction: novel mechanisms and treatments
- (2015) Fabrizio Montecucco et al. EUROPEAN HEART JOURNAL
- Growth differentiation factor 15 in heart failure with preserved vs. reduced ejection fraction
- (2015) Michelle M.Y. Chan et al. EUROPEAN JOURNAL OF HEART FAILURE
- Targeting reperfusion injury in the era of primary percutaneous coronary intervention: hope or hype?
- (2015) Jacob Thomsen Lønborg HEART
- T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients
- (2015) Stephen E. Boag et al. JOURNAL OF CLINICAL INVESTIGATION
- Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
- (2015) Gabriel Ichim et al. MOLECULAR CELL
- Caspase-3 Promotes Genetic Instability and Carcinogenesis
- (2015) Xinjian Liu et al. MOLECULAR CELL
- Cardiomyocyte Regeneration in themdxMouse Model of Nonischemic Cardiomyopathy
- (2015) Gavin David Richardson et al. STEM CELLS AND DEVELOPMENT
- The Impact of Thrombocytopenia on Outcome in Patients with Acute Coronary Syndromes: A Single Center Retrospective Study
- (2015) Andreja Sinkovič et al. Biomed Research International
- Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression
- (2014) Donna Lowe et al. AGING CELL
- Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism
- (2014) Karim Bennaceur et al. ATHEROSCLEROSIS
- Advanced Heart Failure Therapies for Patients With Chemotherapy-Induced Cardiomyopathy
- (2014) Guilherme H. Oliveira et al. Circulation-Heart Failure
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- Mesenchymal stem cells for treatment of aortic aneurysms
- (2014) Aika Yamawaki-Ogata World Journal of Stem Cells
- Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention
- (2013) Ansgar Bruning Anti-Cancer Agents in Medicinal Chemistry
- The Effects of Aging on Apoptosis Following Myocardial Infarction
- (2013) Andrew J. Boyle et al. Cardiovascular Therapeutics
- Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair
- (2013) Georgina M. Ellison et al. CELL
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Heart failure in elderly patients: distinctive features and unresolved issues
- (2013) Valentina Lazzarini et al. EUROPEAN JOURNAL OF HEART FAILURE
- Myocardial ischemia-reperfusion injury: a neglected therapeutic target
- (2013) Derek J. Hausenloy et al. JOURNAL OF CLINICAL INVESTIGATION
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Optimised Protocols for the Identification of the Murine Cardiac Side Population
- (2013) Annette Meeson et al. Stem Cell Reviews and Reports
- Updates on the biology and management of dyskeratosis congenita and related telomere biology disorders
- (2013) Bari J Ballew et al. Expert Review of Hematology
- A senescent cell bystander effect: senescence-induced senescence
- (2012) Glyn Nelson et al. AGING CELL
- Ischemia-Reperfusion Injury
- (2012) Alan D. Widgerow ANNALS OF PLASTIC SURGERY
- The Intersection Between Aging and Cardiovascular Disease
- (2012) Brian J. North et al. CIRCULATION RESEARCH
- Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
- (2012) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart
- (2012) Konstantinos Malliaras et al. EMBO Molecular Medicine
- Telomerase expression in the mammalian heart
- (2012) Gavin D. Richardson et al. FASEB JOURNAL
- Third Universal Definition of Myocardial Infarction
- (2012) Kristian Thygesen et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Cellular Senescence Limits Regenerative Capacity and Allograft Survival
- (2012) H. Braun et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mammalian heart renewal by pre-existing cardiomyocytes
- (2012) Samuel E. Senyo et al. NATURE
- Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
- (2012) Jonathan Ledermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Post-infarct cardiac rupture: Recent insights on pathogenesis and therapeutic interventions
- (2012) Xiao-Ming Gao et al. PHARMACOLOGY & THERAPEUTICS
- Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
- (2012) Graeme Hewitt et al. Nature Communications
- Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
- (2011) S. M. Schoenwaelder et al. BLOOD
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction
- (2010) Denise Hilfiker-Kleiner et al. CIRCULATION
- Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction
- (2010) Masanori Obana et al. CIRCULATION
- Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
- (2010) B. A. Borlaug et al. EUROPEAN HEART JOURNAL
- Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells
- (2010) D.G.A. Burton et al. EXPERIMENTAL GERONTOLOGY
- Upstream stimulatory factor-2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells
- (2010) Nélida C. Olave et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Senescent CD14+CD16+ Monocytes Exhibit Proinflammatory and Proatherosclerotic Activity
- (2010) A. Merino et al. JOURNAL OF IMMUNOLOGY
- Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
- (2010) Wyndham H Wilson et al. LANCET ONCOLOGY
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CXCL10 Can Inhibit Endothelial Cell Proliferation Independently of CXCR3
- (2010) Gabriele S. V. Campanella et al. PLoS One
- DNA damage response and cellular senescence in tissues of aging mice
- (2009) Chunfang Wang et al. AGING CELL
- Dynamics and management of cytopenias associated with dasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure
- (2009) Alfonso Quintás-Cardama et al. CANCER
- Ascending Aortic Dilatation Associated With Bicuspid Aortic Valve
- (2009) Thomas M. Tadros et al. CIRCULATION
- The Burden of Cardiovascular Disease in the Elderly: Morbidity, Mortality, and Costs
- (2009) Ali Yazdanyar et al. CLINICS IN GERIATRIC MEDICINE
- Roles of MAPK and NF-κB in Interleukin-6 Induction by Lipopolysaccharide in Vascular Smooth Muscle Cells
- (2009) Yong-Hae Son et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Aortopathy Is Prevalent in Relatives of Bicuspid Aortic Valve Patients
- (2009) Simon Biner et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- A crucial role for adipose tissue p53 in the regulation of insulin resistance
- (2009) Tohru Minamino et al. NATURE MEDICINE
- Cellular and molecular mechanisms of thoracic aortic aneurysms
- (2009) Ismail El-Hamamsy et al. Nature Reviews Cardiology
- Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation
- (2008) Christian Koppelstaetter et al. AGING CELL
- Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
- (2008) Yasuhiro Maejima et al. AGING CELL
- Cellular senescence in pretransplant renal biopsies predicts postoperative organ function
- (2008) Liane M. McGlynn et al. AGING CELL
- Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
- (2008) L. S.M. Wong et al. CARDIOVASCULAR RESEARCH
- Activation of Cardiac Progenitor Cells Reverses the Failing Heart Senescent Phenotype and Prolongs Lifespan
- (2008) Arantxa Gonzalez et al. CIRCULATION RESEARCH
- Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate
- (2008) M. Brave et al. CLINICAL CANCER RESEARCH
- Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-κB
- (2008) Pankaj K. Bhavsar et al. FASEB JOURNAL
- Expanding the clinical phenotype of autosomal dominant dyskeratosis congenita caused by TERT mutations
- (2008) L. Basel-Vanagaite et al. HAEMATOLOGICA
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