The bone microenvironment invigorates metastatic seeds for further dissemination

The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

(2021) Igor L. Bado et al.   DEVELOPMENTAL CELL

Blocking immunosuppressive neutrophils deters pY696-EZH2–driven brain metastases

(2020) Lin Zhang et al.   Science Translational Medicine

Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer

(2019) Carter Barger et al.   Cancers

PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration

(2019) Zhang Yue et al.   Cell Reports

Discovery of a first-in-class EZH2 selective degrader

(2019) Anqi Ma et al.   Nature Chemical Biology

Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

(2018) Ikram Ullah et al.   JOURNAL OF CLINICAL INVESTIGATION

AR Expression in Breast Cancer CTCs Associates with Bone Metastases

(2018) Nicola Aceto et al.   MOLECULAR CANCER RESEARCH

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program

(2018) Alison Hirukawa et al.   Nature Communications

Developmental barcoding of whole mouse via homing CRISPR

(2018) Reza Kalhor et al.   SCIENCE

The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability

(2018) Hai Wang et al.   CANCER CELL

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

(2018) Gloria V. Echeverria et al.   Nature Communications

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

(2017) Sheng Yu Ku et al.   SCIENCE

The Biology of Bone Metastasis

(2017) Mark Esposito et al.   Cold Spring Harbor Perspectives in Medicine

A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

(2016) George Sflomos et al.   CANCER CELL

Rapidly evolving homing CRISPR barcodes

(2016) Reza Kalhor et al.   NATURE METHODS

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells

(2015) Hai Wang et al.   CANCER CELL

The evolutionary history of lethal metastatic prostate cancer

(2015) Gunes Gundem et al.   NATURE

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

EZH2 expands breast stem cells through activation of NOTCH1 signaling

(2014) M. E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EXPANDS: expanding ploidy and allele frequency on nested subpopulations

(2013) Noemi Andor et al.   BIOINFORMATICS

Origins of Metastatic Traits

(2013) Sakari Vanharanta et al.   CANCER CELL

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway

(2011) Filippos Kottakis et al.   MOLECULAR CELL

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

TGF-β in cancer and bone: Implications for treatment of bone metastases

(2010) Patricia Juárez et al.   BONE

Regulation of Tumor Angiogenesis by EZH2

(2010) Chunhua Lu et al.   CANCER CELL

Metastatic Behavior of Breast Cancer Subtypes

(2010) Hagen Kennecke et al.   JOURNAL OF CLINICAL ONCOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Subtypes of Breast Cancer Show Preferential Site of Relapse

(2008) M. Smid et al.   CANCER RESEARCH

Advancing Treatment for Metastatic Bone Cancer: Consensus Recommendations from the Second Cambridge Conference

(2008) R. E. Coleman et al.   CLINICAL CANCER RESEARCH