The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone

Discovery of the RANKL/RANK/OPG system

(2021) Hisataka Yasuda   JOURNAL OF BONE AND MINERAL METABOLISM

Overexpression of IL-8 promotes cell migration via PI3K-Akt signaling pathway and EMT in triple-negative breast cancer

(2020) Fang Deng et al.   PATHOLOGY RESEARCH AND PRACTICE

TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway

(2020) Wenjing Liu et al.   Scientific Reports

Tumor-Associated Macrophages: Recent Insights and Therapies

(2020) Jiawei Zhou et al.   Frontiers in Oncology

Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment

(2020) Jennifer Zarrer et al.   Biomolecules

CCL2/CCR2 signaling in cancer pathogenesis

(2020) Qiongyu Hao et al.   Cell Communication and Signaling

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling

(2020) Renlun Huang et al.   Cell Death & Disease

Cytokines and Chemokines as Mediators of Prostate Cancer Metastasis

(2020) Timothy O. Adekoya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

(2020) Eunah Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1β and Cancer

(2020) Cédric Rébé et al.   Cancers

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

(2020) Emarndeena H. Cheteh et al.   Cell Death Discovery

Tumor infiltrating immune cells (TIICs) as a biomarker for prognosis benefits in patients with osteosarcoma

(2020) Ying Chen et al.   BMC CANCER

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

(2020) Lea Monteran et al.   Scientific Reports

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis

(2020) Karolina A. Zielińska et al.   Cancers

Bone Marrow Adipocytes, Adipocytokines, and Breast Cancer Cells: Novel Implications in Bone Metastasis of Breast Cancer

(2020) Chang Liu et al.   Frontiers in Oncology

Pro-Inflammatory Cytokines in the Formation of the Pre-Metastatic Niche

(2020) Ru Li et al.   Cancers

Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment.

(2019) Claudia Tulotta et al.   CLINICAL CANCER RESEARCH

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells

(2019) C. Tulotta et al.   Scientific Reports

The Contribution of the Immune System in Bone Metastasis Pathogenesis

(2019) Lisha Xiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Synchronous detection of circulating tumor cells in blood and disseminated tumor cells in bone marrow predict adverse outcome in early breast cancer

(2019) Mark Jesus M. Magbanua et al.   CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

(2019) Micol Eleonora Fiori et al.   Molecular Cancer

IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis

(2019) Mengmeng Liang et al.   Cell Death & Disease

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

(2019) Andrea Walens et al.   eLife

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

The TNF Paradox in Cancer Progression and Immunotherapy

(2019) Anne Montfort et al.   Frontiers in Immunology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Prostate tumor cell-derived IL-1β induces an inflammatory phenotype in bone marrow adipocytes and reduces sensitivity to docetaxel via lipolysis-dependent mechanisms

(2019) Mackenzie K Herroon et al.   MOLECULAR CANCER RESEARCH

miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer

(2019) Qingde Wa et al.   Molecular Therapy-Nucleic Acids

The Role of the CXCL12/CXCR4/ACKR3 Axis in Autoimmune Diseases

(2019) Eva M. García-Cuesta et al.   Frontiers in Endocrinology

NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

(2019) Nour Ershaid et al.   Nature Communications

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

(2019) Rachel Eyre et al.   Nature Communications

Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis

(2019) Bridie S. Mulholland et al.   Current Osteoporosis Reports

Tumor-Infiltrating Immune Cells Act as a Marker for Prognosis in Colorectal Cancer

(2019) Lele Ye et al.   Frontiers in Immunology

Insights Into Mechanisms of Tumor and Immune System Interaction: Association With Wound Healing

(2019) Aleksandr V. Ponomarev et al.   Frontiers in Oncology

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

What Is the Role of Interleukins in Breast Cancer Bone Metastases? A Systematic Review of Preclinical and Clinical Evidence

(2019) Francesca Salamanna et al.   Cancers

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies

(2018) Yan Qiao et al.   BMC CANCER

The role of IL-1B in breast cancer bone metastasis

(2018) Claudia Tulotta et al.   ENDOCRINE-RELATED CANCER

Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis

(2018) Nicola Graham et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-6 receptor inhibitor suppresses bone metastases in a breast cancer cell line

(2018) Hiroki Wakabayashi et al.   Breast Cancer

Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells

(2018) Jones Gyamfi et al.   Scientific Reports

The Regulation of Inflammation by Innate and Adaptive Lymphocytes

(2018) David Alex Cronkite et al.   Journal of Immunology Research

Immunological Approaches Towards Cancer and Inflammation: A Cross Talk

(2018) Xinglong Qu et al.   Frontiers in Immunology

Role of Tumor-Derived Chemokines in Osteolytic Bone Metastasis

(2018) Salvatore J. Coniglio   Frontiers in Endocrinology

The Osteoclast in Bone Metastasis: Player and Target

(2018) Antonio Maurizi et al.   Cancers

The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer

(2018) Ali Masjedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis

(2018) J.D. Jones et al.   NEOPLASIA

Metastatic bone disease: Pathogenesis and therapeutic options

(2018) Stella D'Oronzo et al.   Journal of Bone Oncology

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

(2017) Hernan Roca et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway

(2017) Dong Ren et al.   Molecular Cancer

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

Adapting to obesity with adipose tissue inflammation

(2017) Shannon M. Reilly et al.   Nature Reviews Endocrinology

Exogenous lipids promote the growth of breast cancer cells via CD36

(2017) Jing Zhao et al.   ONCOLOGY REPORTS

Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer

(2017) A. S. Noman et al.   Scientific Reports

Cytokines in cancer drug resistance: Cues to new therapeutic strategies

(2016) Valerie Sloane Jones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

(2016) J. Delgado-Calle et al.   CANCER RESEARCH

Obesity and Breast Cancer Prognosis: Evidence, Challenges, and Opportunities

(2016) Sao Jiralerspong et al.   JOURNAL OF CLINICAL ONCOLOGY

Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis

(2016) M. Katie Conley-LaComb et al.   Molecular Cancer

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils

(2016) P F Yu et al.   ONCOGENE

Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment

(2016) Ramin Lotfi et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Role of interleukin-6 in cancer progression and therapeutic resistance

(2016) Neeraj Kumari et al.   TUMOR BIOLOGY

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6

(2016) Guang-Liang Chen et al.   Oncotarget

IL-1 drives breast cancer growth and bone metastasis in vivo

(2016) Ingunn Holen et al.   Oncotarget

Targeting the CCL2-CCR2 signaling axis in cancer metastasis

(2016) Su Yin Lim et al.   Oncotarget

The Bone Microenvironment: a Fertile Soil for Tumor Growth

(2016) Denise Buenrostro et al.   Current Osteoporosis Reports

Clinical significance of tumor-infiltrating lymphocytes in breast cancer

(2016) Sasha E. Stanton et al.   Journal for ImmunoTherapy of Cancer

Tumor-Induced Pressure in the Bone Microenvironment Causes Osteocytes to Promote the Growth of Prostate Cancer Bone Metastases

(2015) Joseph L. Sottnik et al.   CANCER RESEARCH

Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment

(2015) Donna M. Sosnoski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions

(2015) I. Holen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer

(2015) Aimalie L. Hardaway et al.   CLINICAL & EXPERIMENTAL METASTASIS

BMP2 Regulation of CXCL12 Cellular, Temporal, and Spatial Expression Is Essential During Fracture Repair

(2015) Timothy J Myers et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis

(2015) Hye Min Kim et al.   Journal of Translational Medicine

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Inflammation and cancer: advances and new agents

(2015) Shanthini M. Crusz et al.   Nature Reviews Clinical Oncology

Bone marrow macrophages support prostate cancer growth in bone

(2015) Fabiana N. Soki et al.   Oncotarget

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

(2015) Rinaldo Florencio-Silva et al.   Biomed Research International

Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche

(2015) Zach S. Templeton et al.   NEOPLASIA

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

(2015) Mackenzie Herroon et al.   Oncotarget

ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling

(2015) Tetsuro Masuda et al.   Scientific Reports

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

(2015) Kosuke Mizutani et al.   NEOPLASIA

Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

(2014) Lopamudra Das Roy et al.   BMC CANCER

Modifying the osteoblastic niche with zoledronic acid in vivo—Potential implications for breast cancer bone metastasis

(2014) Marie-Therese Haider et al.   BONE

Circulating interleukin-8 levels explain breast cancer osteolysis in mice and humans

(2014) Archana Kamalakar et al.   BONE

Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases

(2014) Aimalie L. Hardaway et al.   CANCER AND METASTASIS REVIEWS

Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages

(2014) Dennis Shin-Shian Hsu et al.   CANCER CELL

A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial–mesenchymal transition in breast cancer cells

(2014) Eloy Andres Perez-Yepez et al.   CANCER LETTERS

Dickkopf-1 as a mediator and novel target in malignant bone disease

(2014) Tilman D. Rachner et al.   CANCER LETTERS

Different molecular profiles are associated with breast cancer cell homing compared with colonisation of bone: evidence using a novel bone-seeking cell line

(2014) Faith Nutter et al.   ENDOCRINE-RELATED CANCER

Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways

(2014) Yu Zheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chemokine (C-X-C motif) receptor 4 RNA interference inhibits bone metastasis in breast cancer

(2014) HENG ZENG et al.   Oncology Letters

Endocrine aspects of bone metastases

(2014) Lorenz C Hofbauer et al.   Lancet Diabetes & Endocrinology

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice

(2013) Marta Garcia et al.   BJU INTERNATIONAL

IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells

(2013) Erin M McCoy et al.   BMC CANCER

A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

(2013) P.C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Virus induced inflammation and cancer development

(2013) Scott A. Read et al.   CANCER LETTERS

Interleukin-1  Promotes Skeletal Colonization and Progression of Metastatic Prostate Cancer Cells with Neuroendocrine Features

(2013) Q. Liu et al.   CANCER RESEARCH

Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8

(2013) Z. C. Hartman et al.   CANCER RESEARCH

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway

(2013) Li Ren et al.   MEDICAL ONCOLOGY

Activation of NF-kappa B Signaling Promotes Growth of Prostate Cancer Cells in Bone

(2013) Renjie Jin et al.   PLoS One

High-level expression of CXCR4 in breast cancer is associated with early distant and bone metastases

(2013) Chin-Sheng Hung et al.   TUMOR BIOLOGY

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites

(2012) Jiehui Deng et al.   CANCER CELL

Cyclophosphamide Creates a Receptive Microenvironment for Prostate Cancer Skeletal Metastasis

(2012) S. I. Park et al.   CANCER RESEARCH

CXCL10 Promotes Osteolytic Bone Metastasis by Enhancing Cancer Outgrowth and Osteoclastogenesis

(2012) J.-H. Lee et al.   CANCER RESEARCH

Loss of TGF-  Responsiveness in Prostate Stromal Cells Alters Chemokine Levels and Facilitates the Development of Mixed Osteoblastic/Osteolytic Bone Lesions

(2012) X. Li et al.   MOLECULAR CANCER RESEARCH

Macrophage cathepsin K promotes prostate tumor progression in bone

(2012) M K Herroon et al.   ONCOGENE

Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/Snail signaling pathway

(2012) Y-L Hsu et al.   ONCOGENE

TNF inhibitor suppresses bone metastasis in a breast cancer cell line

(2011) Takahiko Hamaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy: results from the SEARCH database

(2011) Christopher J. Keto et al.   BJU INTERNATIONAL

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

(2011) Lopamudra Das Roy et al.   BMC CANCER

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

2011: the immune hallmarks of cancer

(2011) Federica Cavallo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of VEGF, MMP-9 and metastasis by CXCR4 in a prostate cancer cell line

(2011) Qinwen Wang et al.   CELL BIOLOGY INTERNATIONAL

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse

(2011) Seung Wook Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis

(2011) Yvette Drabsch et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Breast-Cancer Adjuvant Therapy with Zoledronic Acid

(2011) Robert E. Coleman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal cell-derived factor-1 and vascular endothelial growth factor as biomarkers for lymph node metastasis and poor cancer-specific survival in prostate cancer patients after radical prostatectomy

(2011) Qinwen Wang et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies

(2011) Cheryl Jorcyk et al.   Cancer Management and Research

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

(2010) Hiroyuki Takahashi et al.   CANCER CELL

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Receptor Activator of NF- B Ligand Enhances Breast Cancer-Induced Osteolytic Lesions through Upregulation of Extracellular Matrix Metalloproteinase Inducer/CD147

(2010) N. Rucci et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

(2010) L. E. Wroblewski et al.   CLINICAL MICROBIOLOGY REVIEWS

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice

(2010) Ganesh V. Halade et al.   EXPERIMENTAL GERONTOLOGY

Osteoblasts are a major source of inflammatory cytokines in the tumor microenvironment of bone metastatic breast cancer

(2010) Karen M. Bussard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Saturated fatty acids enhance osteoclast survival

(2010) S. R. Oh et al.   JOURNAL OF LIPID RESEARCH

The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer

(2010) Roy M. Bremnes et al.   Journal of Thoracic Oncology

Obesity Reduces Bone Density Associated with Activation of PPARγ and Suppression of Wnt/β-Catenin in Rapidly Growing Male Rats

(2010) Jin-Ran Chen et al.   PLoS One

Prostaglandins in bone: bad cop, good cop?

(2010) Katherine A. Blackwell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

(2009) A. K. Azab et al.   BLOOD

A Destructive Cascade Mediated by CCL2 Facilitates Prostate Cancer Growth in Bone

(2009) Xin Li et al.   CANCER RESEARCH

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model

(2009) Munehisa Takahashi et al.   CLINICAL & EXPERIMENTAL METASTASIS

Reduced Risk of Bone Metastasis for Patients With Breast Cancer Who Use COX-2 Inhibitors

(2009) Matias E. Valsecchi et al.   Clinical Breast Cancer

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Chemokine (C-C Motif) Ligand 2 Engages CCR2+Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone

(2009) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization

(2009) Hernan Roca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF- B Activation, Dependent on Acetylation/Deacetylation, Contributes to HIF-1 Activity and Migration of Bone Metastatic Breast Carcinoma Cells

(2009) P. Bendinelli et al.   MOLECULAR CANCER RESEARCH

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Gene expression profile of the bone microenvironment in human fragility fracture bone

(2008) B. Hopwood et al.   BONE

Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow

(2008) Anthony Lucci et al.   BREAST CANCER RESEARCH AND TREATMENT

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

(2008) Takuya Akashi et al.   CANCER SCIENCE

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

(2008) Koji Hiraoka et al.   CANCER SCIENCE

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone

(2008) Yi Lu et al.   CLINICAL & EXPERIMENTAL METASTASIS

Metastatic breast cancer cells colonize and degrade three-dimensional osteoblastic tissue in vitro

(2008) Ravi Dhurjati et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells

(2008) Alan P. Molloy et al.   INTERNATIONAL JOURNAL OF CANCER

Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C

(2008) Francesca M. Tumminello et al.   MEDICAL ONCOLOGY

Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growth

(2008) T. Takahashi et al.   MOLECULAR CANCER THERAPEUTICS

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Metastatic breast cancer induces an osteoblast inflammatory response

(2007) Michelle Kinder et al.   EXPERIMENTAL CELL RESEARCH