Diflunisal targets the HMGB 1/ CXCL 12 heterocomplex and blocks immune cell recruitment

Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

(2018) Mingzhu He et al.   MOLECULAR MEDICINE

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert

(2018) Geoffrey Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

(2018) Tanja Bartoschik et al.   Scientific Reports

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4

(2017) Paul J. Collins et al.   FASEB JOURNAL

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

High mobility group box 1 orchestrates tissue regeneration via CXCR4

(2017) Mario Tirone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Mobility Group Box-1 (HMGb1): Current Wisdom and Advancement as a Potential Drug Target

(2017) Sonya VanPatten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multitarget Drug Discovery and Polypharmacology

(2016) Maria Laura Bolognesi et al.   ChemMedChem

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

(2016) Kotaro Shirakawa et al.   eLife

Modulation of Chemokine Responses: Synergy and Cooperativity

(2016) Amanda E. I. Proudfoot et al.   Frontiers in Immunology

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions

(2015) Luca Laraia et al.   CHEMISTRY & BIOLOGY

Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking

(2015) Valentina Cecchinato et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Unknown

(2015) Hyong Choi et al.   MOLECULAR MEDICINE

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression

(2015) H Yang et al.   Cell Death & Disease

Polypharmacology: Challenges and Opportunities in Drug Discovery

(2014) Andrew Anighoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery

(2013) Joshua J. Ziarek et al.   ACS Chemical Biology

Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions

(2012) Patricia Rueda et al.   CIRCULATION

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response

(2012) Mieke Gouwy et al.   IMMUNOLOGY LETTERS

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Molecular Interaction Studies Using Microscale Thermophoresis

(2011) Moran Jerabek-Willemsen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB

(2011) Camilla T. O. Benfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12

(2009) Christopher T. Veldkamp et al.   PROTEIN SCIENCE

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling