Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
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Title
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
Authors
Keywords
-
Journal
AGING CELL
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2023-07-21
DOI
10.1111/acel.13921
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Related references
Note: Only part of the references are listed.- Hallmarks of aging: An expanding universe
- (2023) Carlos López-Otín et al. CELL
- Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition
- (2023) Piera Tocci et al. Cell Death & Disease
- An Innovative Approach for Formulation of Rutin Tablets Targeted for Colon Cancer Treatment
- (2023) Aliaa Ismail et al. AAPS PHARMSCITECH
- Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity
- (2023) Yulan Liu et al. BMC NEUROSCIENCE
- A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress
- (2023) Xavier Morató et al. Scientific Reports
- Self-Assembled Nanodelivery System with Rapamycin and Curcumin for Combined Photo-Chemotherapy of Breast Cancer
- (2023) Yanlong Yin et al. Pharmaceutics
- Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
- (2022) Lei Zhang et al. FEBS Journal
- Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells
- (2022) P I Deryabin et al. HUMAN REPRODUCTION
- STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway
- (2022) Qingqiu Chen et al. LIFE SCIENCES
- Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia
- (2022) Akram Hamidi et al. Cells
- Senescence and cancer — role and therapeutic opportunities
- (2022) Clemens A. Schmitt et al. Nature Reviews Clinical Oncology
- The role of hypoxia-inducible factors in cardiovascular diseases
- (2022) Baoqi Yu et al. PHARMACOLOGY & THERAPEUTICS
- Chemotherapy induces senescence-like resilient cells capable of initiating AML recurrence
- (2021) Cihangir Duy et al. Cancer Discovery
- Sodium rutin extends lifespan and health span in mice including positive impacts on liver health
- (2021) Shuoshuo Li et al. BRITISH JOURNAL OF PHARMACOLOGY
- Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases
- (2021) Sofia M. Lagoumtzi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin
- (2021) Cheng Xu et al. Science Advances
- Tumor microenvironment and cellular senescence: Understanding therapeutic resistance and harnessing strategies
- (2021) Hanxin Liu et al. SEMINARS IN CANCER BIOLOGY
- Senescent stromal cells promote cancer resistance through SIRT1 loss-potentiated overproduction of small extracellular vesicles
- (2020) Liu Han et al. CANCER RESEARCH
- The quest to slow ageing through drug discovery
- (2020) Linda Partridge et al. NATURE REVIEWS DRUG DISCOVERY
- Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
- (2020) Shuling Song et al. TRENDS IN BIOCHEMICAL SCIENCES
- Senolytic drugs: from discovery to translation
- (2020) J. L. Kirkland et al. JOURNAL OF INTERNAL MEDICINE
- Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations
- (2020) Vera Marisa Costa et al. ARCHIVES OF TOXICOLOGY
- Therapeutic benefits of rutin and its nanoformulations
- (2020) Ramin Negahdari et al. PHYTOTHERAPY RESEARCH
- Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
- (2020) Shuling Song et al. Advanced Science
- Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling
- (2019) Shuo Qiu et al. Journal of Diabetes Research
- Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression
- (2019) Qixia Xu et al. AGING CELL
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1
- (2018) Boyi Zhang et al. Nature Communications
- Quercetin Enhances Ligand-induced Apoptosis in Senescent IPF Fibroblasts and Reduces Lung Fibrosis In Vivo
- (2018) Miriam S Hohmann et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Cellular Senescence: The Sought or the Unwanted?
- (2018) Yu Sun et al. TRENDS IN MOLECULAR MEDICINE
- Chemical screen identifies a geroprotective role of quercetin in premature aging
- (2018) Lingling Geng et al. Protein & Cell
- The BioGRID interaction database: 2019 update
- (2018) Rose Oughtred et al. NUCLEIC ACIDS RESEARCH
- Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
- (2018) Fei Chen et al. Nature Communications
- Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability
- (2017) Beatriz Gullón et al. TRENDS IN FOOD SCIENCE & TECHNOLOGY
- Rutin as Neuroprotective Agent: From Bench to Bedside
- (2017) Barbara Budzynska et al. CURRENT MEDICINAL CHEMISTRY
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
- (2016) Christopher D. Wiley et al. Cell Metabolism
- A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis
- (2016) Abdol-Hossein Rezaeian et al. NATURE CELL BIOLOGY
- SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment
- (2016) Y Sun et al. ONCOGENE
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts
- (2015) Hyun Lim et al. BIOCHEMICAL PHARMACOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
- (2015) Joel D. Leverson et al. Science Translational Medicine
- The Ensembl Regulatory Build
- (2015) Daniel R Zerbino et al. GENOME BIOLOGY
- Phase I clinical trial of pegylated liposomal mitoxantrone plm60-s: pharmacokinetics, toxicity and preliminary efficacy
- (2014) Jianliang Yang et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B
- (2012) Yu Sun et al. NATURE MEDICINE
- Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
- (2012) Cole Trapnell et al. Nature Protocols
- Entrez Gene: gene-centered information at NCBI
- (2010) D. Maglott et al. NUCLEIC ACIDS RESEARCH
- The Universal Protein Resource (UniProt) in 2010
- (2009) NUCLEIC ACIDS RESEARCH
- Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks
- (2008) David A Nix et al. BMC BIOINFORMATICS
- Development of an oral rutin nanocrystal formulation
- (2008) Rachmat Mauludin et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Human Protein Reference Database--2009 update
- (2008) T. S. Keshava Prasad et al. NUCLEIC ACIDS RESEARCH
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