The Cancer SENESCopedia: A delineation of cancer cell senescence

H2A.Z overexpression suppresses senescence and chemosensitivity in pancreatic ductal adenocarcinoma

(2021) P. A. Ávila-López et al.   ONCOGENE

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

(2020) Marcus Ruscetti et al.   CELL

BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer

(2020) Ashkan Shahbandi et al.   CELL DEATH AND DIFFERENTIATION

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

(2020) Kurt A. Schalper et al.   NATURE MEDICINE

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

(2020) Kobe C. Yuen et al.   NATURE MEDICINE

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

(2020) Yonghan He et al.   Nature Communications

AP-1 imprints a reversible transcriptional programme of senescent cells

(2020) Ricardo Iván Martínez-Zamudio et al.   NATURE CELL BIOLOGY

Functional determinants of cell-cycle plasticity and sensitivity to CDK4/6 inhibition

(2020) Vishnu Kumarasamy et al.   CANCER RESEARCH

Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence

(2020) Kamal Pandey et al.   Cancers

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

The chemistry of senescence

(2019) Beatriz Lozano-Torres et al.   Nature Reviews Chemistry

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

CLASTR: The Cellosaurus STR similarity search tool ‐ A precious help for cell line authentication

(2019) Thibault Robin et al.   INTERNATIONAL JOURNAL OF CANCER

Inducing and exploiting vulnerabilities for the treatment of liver cancer

(2019) Cun Wang et al.   NATURE

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

(2019) Sajid Khan et al.   NATURE MEDICINE

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

(2018) Sara Mainardi et al.   NATURE MEDICINE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Single sample scoring of molecular phenotypes

(2018) Momeneh Foroutan et al.   BMC BIOINFORMATICS

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

(2018) Takayuki Nojima et al.   MOLECULAR CELL

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice

(2017) Jin Pan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Control of Gene Expression in Senescence through Transcriptional Read-Through of Convergent Protein-Coding Genes

(2017) Lisa Muniz et al.   Cell Reports

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Senescence from G2 arrest, revisited

(2015) Véronique Gire et al.   CELL CYCLE

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics

(2015) C Touzeau et al.   LEUKEMIA

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer

(2015) Huifeng Niu et al.   Frontiers in Oncology

Exploiting tumor cell senescence in anticancer therapy

(2014) Minyoung Lee et al.   BMB Reports

Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia

(2014) Aksana Kaefer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells

(2014) Bin Wang et al.   Molecular Cancer

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Lentiviral Delivery of RNAi for In Vivo Lineage-Specific Modulation of Gene Expression in Mouse Lung Macrophages

(2013) Andrew A Wilson et al.   MOLECULAR THERAPY

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

(2013) M Marxer et al.   ONCOGENE

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Cellular senescence predicts treatment outcome in metastasised colorectal cancer

(2010) A M Haugstetter et al.   BRITISH JOURNAL OF CANCER

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

A signature-based method for indexing cell cycle phase distribution from microarray profiles

(2009) Hideaki Mizuno et al.   BMC GENOMICS

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY