Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

(2022) Boshi Wang et al.   EMBO JOURNAL

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

(2021) Valerie J. Carpenter et al.   Cancers

Is Senescence-Associated β-Galactosidase a Reliable in vivo Marker of Cellular Senescence During Embryonic Development?

(2021) José Antonio de Mera-Rodríguez et al.   Frontiers in Cell and Developmental Biology

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging

(2021) Natalie Kudlova et al.   Aging-US

d ‐Galactose induced early aging in human erythrocytes: Role of band 3 protein

(2021) Alessia Remigante et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Strategies for late phase preclinical and early clinical trials of senolytics

(2021) Erin O. Wissler Gerdes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects

(2021) Marco Raffaele et al.   GeroScience

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

(2020) Harikrishnan Thoppil et al.   Frontiers in Cell and Developmental Biology

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

(2020) Estela González‐Gualda et al.   AGING CELL

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

(2020) Erik S Knudsen et al.   GUT

Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours

(2020) Ellen Brenner et al.   Nature Communications

Multiparameter flow cytometric detection and quantification of senescent cells in vitro

(2020) Adeolu Badi Adewoye et al.   BIOGERONTOLOGY

Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword

(2020) Anthony M. Battram et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐X L –BAX interaction

(2020) Tareq Saleh et al.   Molecular Oncology

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Curcumin protects thymus against D-galactose-induced senescence in mice

(2020) Jie-han Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Role of immune cells in the removal of deleterious senescent cells

(2020) Abhijit Kale et al.   Immunity & Ageing

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

(2020) Lorenzo Cuollo et al.   Biology-Basel

Senolytics and senostatics as adjuvant tumour therapy

(2019) Susan Short et al.   EBioMedicine

Real-time imaging of senescence in tumors with DNA damage

(2019) Ying Wang et al.   Scientific Reports

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy

(2019) Tareq Saleh et al.   CANCER RESEARCH

Autophagy and senescence: A new insight in selected human diseases

(2019) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

(2019) Abel Soto-Gamez et al.   JOURNAL OF MOLECULAR BIOLOGY

Automation in cell and gene therapy manufacturing: from past to future

(2019) P. Moutsatsou et al.   BIOTECHNOLOGY LETTERS

The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

(2019) Al Bitar et al.   Cancers

Targeting normal and cancer senescent cells as a strategy of senotherapy

(2019) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Inducing and exploiting vulnerabilities for the treatment of liver cancer

(2019) Cun Wang et al.   NATURE

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Insights into replicative senescence of human testicular peritubular cells

(2019) Nina Schmid et al.   Scientific Reports

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

Oxidation resistance 1 is a novel senolytic target

(2018) Xin Zhang et al.   AGING CELL

Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence

(2018) Blanka Mrazkova et al.   Aging-US

Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation

(2018) Xingui Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

(2018) Sona Hubackova et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

(2018) Brent E. Fitzwalter et al.   DEVELOPMENTAL CELL

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Role of Forkhead Box O (FOXO) transcription factor in aging and diseases

(2018) Neelam Tia et al.   GENE

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

(2018) Christopher D. Wiley et al.   Scientific Reports

Preclinical evaluation of ribociclib and its synergistic effect in combination with alpelisib in non-keratinizing nasopharyngeal carcinoma

(2018) Chi-Hang Wong et al.   Scientific Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Molybdenum Disulfide Nanoparticles Resist Oxidative Stress-Mediated Impairment of Autophagic Flux and Mitigate Endothelial Cell Senescence and Angiogenic Dysfunctions

(2018) Sunkui Ke et al.   ACS Biomaterials-Science & Engineering

Molybdenum Disulfide Nanoparticles Resist Oxidative Stress-Mediated Impairment of Autophagic Flux and Mitigate Endothelial Cell Senescence and Angiogenic Dysfunctions

(2018) Sunkui Ke et al.   ACS Biomaterials Science & Engineering

Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence

(2018) Yan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs

(2018) Khushboo Agrawal et al.   Stem Cells International

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

(2018) Fan Zhang et al.   CELL CYCLE

Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and Oxidative Stress

(2018) Kaiyue Sun et al.   Oxidative Medicine and Cellular Longevity

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Palbociclib-induced autophagy and senescence in gastric cancer cells

(2017) Claudio A. Valenzuela et al.   EXPERIMENTAL CELL RESEARCH

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

An OFF–ON Two-Photon Fluorescent Probe for Tracking Cell Senescence in Vivo

(2017) Beatriz Lozano-Torres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

CDK4/6 inhibition triggers anti-tumour immunity

(2017) Shom Goel et al.   NATURE

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose–induced aging mice

(2017) Farzad Salehpour et al.   NEUROBIOLOGY OF AGING

ATRX is a regulator of therapy induced senescence in human cells

(2017) Marta Kovatcheva et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

(2017) Jiehui Deng et al.   Cancer Discovery

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Techniques to Induce and Quantify Cellular Senescence

(2017) Nicole Noren Hooten et al.   Jove-Journal of Visualized Experiments

Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles

(2017) Raj Kumar Thapa et al.   Scientific Reports

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

(2016) A. Yoshida et al.   CANCER RESEARCH

BH4 domain of Bcl-2 as a novel target for cancer therapy

(2016) Zhiqing Liu et al.   DRUG DISCOVERY TODAY

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Protective Effect of Hyperbaric Oxygen on Cognitive Impairment Induced by d-Galactose in Mice

(2016) Xiaoyu Chen et al.   NEUROCHEMICAL RESEARCH

Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence

(2016) Priyanka L. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases

(2016) Yingying Wang et al.   RADIATION RESEARCH

Pathology of Mouse Models of Accelerated Aging

(2016) L. Harkema et al.   VETERINARY PATHOLOGY

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Is senescence-associated β-galactosidase a marker of neuronal senescence?

(2016) Malgorzata Piechota et al.   Oncotarget

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2

(2015) Dauren Alimbetov et al.   BIOGERONTOLOGY

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

The impact of moderate wine consumption on health

(2015) Ana Artero et al.   MATURITAS

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Radical Oxygen Species, Exercise and Aging: An Update

(2015) Mohamed Amine Bouzid et al.   SPORTS MEDICINE

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

(2015) Marta Kovatcheva et al.   Oncotarget

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling

(2015) David W. P. Dolan et al.   PLoS Computational Biology

Ratiometric Two-Photon Fluorescent Probe for Quantitative Detection of β-Galactosidase Activity in Senescent Cells

(2014) Hyo Won Lee et al.   ANALYTICAL CHEMISTRY

Radiation-induced accelerated senescence

(2014) Regina M Day et al.   CELL CYCLE

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

(2014) Lawrence M. Gelbert et al.   INVESTIGATIONAL NEW DRUGS

Double-Edged Swords as Cancer Therapeutics: Novel, Orally Active, Small Molecules Simultaneously Inhibit p53–MDM2 Interaction and the NF-κB Pathway

(2014) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial

(2014) Frits van Rhee et al.   LANCET ONCOLOGY

Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer.

(2014) S. Kim et al.   MOLECULAR CANCER THERAPEUTICS

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ionizing Radiation Sensitizes Breast Cancer Cells to Bcl-2 Inhibitor, ABT-737, through Regulating Mcl-1

(2014) Hao Wu et al.   RADIATION RESEARCH

Characterization of novel markers of senescence and their prognostic potential in cancer

(2014) M Althubiti et al.   Cell Death & Disease

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

α-Fucosidase as a novel convenient biomarker for cellular senescence

(2013) Dominic Hildebrand et al.   CELL CYCLE

Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

(2013) J. Rader et al.   CLINICAL CANCER RESEARCH

p16INK4a reporter mice reveal age-promoting effects of environmental toxicants

(2013) Jessica A. Sorrentino et al.   JOURNAL OF CLINICAL INVESTIGATION

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

(2013) Alexandre Iannello et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prolonged expression of senescence markers in mice exposed to gamma-irradiation

(2013) Min-A Seol et al.   Journal of Veterinary Science

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles

(2012) Alessandro Agostini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling

(2012) Zsolt Radak et al.   ANTIOXIDANTS & REDOX SIGNALING

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

Selenium and Clinical Trials: New Therapeutic Evidence for Multiple Diseases

(2012) C. Sanmartin et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Emerging roles of RB family: New defense mechanisms against tumor progression

(2012) Paola Indovina et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts

(2012) V. Pitozzi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells

(2011) Lars Anders et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ganoderma lucidum polysaccharides prevent platelet-derived growth factor-stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial-denuded artery in vivo

(2011) Shu-Huei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin improves d-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression

(2011) Dae Young Yoo et al.   JOURNAL OF PINEAL RESEARCH

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

(2010) Oanh N. L. Le et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

γH2AX as a molecular marker of aging and disease

(2010) Li-Jeen Mah et al.   Epigenetics

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Senescence and p130/Rbl2: a new beginning to the end

(2009) Francesco P Fiorentino et al.   CELL RESEARCH

The human selenoproteome: recent insights into functions and regulation

(2009) M. A. Reeves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Concurrent and Sequential Administration of Chemotherapy and the Mammalian Target of Rapamycin Inhibitor Temsirolimus in Human Cancer Cells and Xenografts

(2009) A. S. Fung et al.   CLINICAL CANCER RESEARCH

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Rb2/p130 is the dominating pocket protein in the p53–p21 DNA damage response pathway leading to senescence

(2009) H Helmbold et al.   ONCOGENE

Detection of S-phase cell cycle progression using 5-ethynyl-2′-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2′-deoxyuridine antibodies

(2008) Suzanne B. Buck et al.   BIOTECHNIQUES

Therapeutic Efficacy of ABT-737, a Selective Inhibitor of BCL-2, in Small Cell Lung Cancer

(2008) C. L. Hann et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Characterization of the p53 Response to Oncogene-Induced Senescence

(2008) Lidia Ruiz et al.   PLoS One