Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

(2020) Alessandra Metelli et al.   Science Translational Medicine

Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers

(2020) M. Syed et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Fibroblast imaging of hepatic carcinoma with 68Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules

(2020) Ximin Shi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Fibroblast Activation Protein (FAP) specific PET for advanced target volume delineation in glioblastoma

(2020) Paul Windisch et al.   RADIOTHERAPY AND ONCOLOGY

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

(2019) Shivani Srivastava et al.   CANCER CELL

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms

(2019) Xing Wei et al.   Cell Stem Cell

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer

(2019) Clemens Kratochwil et al.   JOURNAL OF NUCLEAR MEDICINE

Fibroblast as a critical stromal cell type determining prognosis in prostate cancer

(2019) Sami Blom et al.   PROSTATE

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

(2019) Christina Claus et al.   Science Translational Medicine

Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP)

(2019) An De Decker et al.   ACS Medicinal Chemistry Letters

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

The development and validation of a combined kinetic fluorometric activity assay for fibroblast activation protein alpha and prolyl oligopeptidase in plasma

(2019) An Bracke et al.   CLINICA CHIMICA ACTA

Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy

(2019) Shiping Jiao et al.   CELL

Fibroblastic FAP promotes intrahepatic cholangiocarcinoma growth via MDSCs recruitment

(2019) Yuli Lin et al.   NEOPLASIA

Toxicological profile and safety pharmacology of a single dose of fibroblast activation protein-α-based doxorubicin prodrug

(2018) Sichao Huang et al.   ANTI-CANCER DRUGS

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Aberrant Lck Signal via CD28 Costimulation Augments Antigen-Specific Functionality and Tumor Control by Redirected T Cells with PD-1 Blockade in Humanized Mice

(2018) Pratiksha Gulati et al.   CLINICAL CANCER RESEARCH

Development of quinoline based theranostic ligands for the targeting of fibroblast activation protein

(2018) Thomas Lindner et al.   JOURNAL OF NUCLEAR MEDICINE

A new method for tumor imaging by targeting cancer associated fibroblasts

(2018) Anastasia Loktev et al.   JOURNAL OF NUCLEAR MEDICINE

Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts

(2018) Diana Avery et al.   MATRIX BIOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

(2018) Ellen Puré et al.   ONCOGENE

Imaging fibroblast activation protein to monitor therapeutic effects of neutralizing interleukin-22 in collagen-induced arthritis

(2018) Tessa van der Geest et al.   RHEUMATOLOGY

Identification of the Human Skeletal Stem Cell

(2018) Charles K.F. Chan et al.   CELL

FAPI-PET/CT: biodistribution and preliminary dosimetry estimate of two DOTA-containing FAP-targeting agents in patients with various cancers

(2018) Frederik Giesel et al.   JOURNAL OF NUCLEAR MEDICINE

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

(2018) Hui Emma Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

FAP delineates heterogeneous and functionally divergent stromal cells in immune-excluded breast tumors

(2018) Viviana Cremasco et al.   Cancer Immunology Research

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

(2018) Timothy E. Krueger et al.   PROSTATE

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

(2018) Ankur Chakravarthy et al.   Nature Communications

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents

(2017) Minfeng Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity

(2017) Li-Juan Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease

(2017) Shirley Uitte de Willige et al.   PLoS One

Mesenchymal stem cell infiltration during neoplastic transformation of the human prostate

(2017) W. Nathaniel Brennen et al.   Oncotarget

Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)

(2017) Travis W. Bainbridge et al.   Scientific Reports

A specific, transmembrane interface regulates fibroblast activation protein (FAP) homodimerization, trafficking and exopeptidase activity

(2016) Benjamaporn Wonganu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Heterogeneity of the bone marrow niche

(2016) Vionnie W.C. Yu et al.   CURRENT OPINION IN HEMATOLOGY

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21

(2016) Diana Ronai Dunshee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liposomal Treatment of Experimental Arthritis Can Be Monitored Noninvasively with a Radiolabeled Anti–Fibroblast Activation Protein Antibody

(2016) Tessa van der Geest et al.   JOURNAL OF NUCLEAR MEDICINE

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma

(2016) Pok Fai Wong et al.   PEPTIDES

Rapid selection of mesenchymal stem and progenitor cells in primary prostate stromal cultures

(2016) W. Nathaniel Brennen et al.   PROSTATE

Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy

(2016) Emmanuel S. Akinboye et al.   PROSTATE

Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay

(2016) W. Nathaniel Brennen et al.   Oncotarget

A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma

(2016) Jinxu Fang et al.   Molecular Therapy-Oncolytics

Human FGF-21 Is a Substrate of Fibroblast Activation Protein

(2016) Andrew L. Coppage et al.   PLoS One

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

(2015) E. Y. Zhen et al.   BIOCHEMICAL JOURNAL

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Mesenchymal Cell Contributions to the Stem Cell Niche

(2015) Youmna Kfoury et al.   Cell Stem Cell

The MSC curtain that stops the immune system

(2015) Arnold I. Caplan et al.   IMMUNOLOGY LETTERS

A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice

(2015) Jinxu Fang et al.   INTERNATIONAL JOURNAL OF CANCER

Immuno-PET and Immuno-SPECT of Rheumatoid Arthritis with Radiolabeled Anti-Fibroblast Activation Protein Antibody Correlates with Severity of Arthritis

(2015) P. Laverman et al.   JOURNAL OF NUCLEAR MEDICINE

Latent TGF-β-binding proteins

(2015) Ian B. Robertson et al.   MATRIX BIOLOGY

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

(2015) M.M. Koczorowska et al.   Molecular Oncology

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

The Effect of pH on the Extracellular Matrix and Biofilms

(2015) Eleri M. Jones et al.   Advances in Wound Care

Fibroblast Activation Protein Overexpression and Clinical Implications in Solid Tumors: A Meta-Analysis

(2015) Fang Liu et al.   PLoS One

Engineering Enzymatically Activated “Molecular Grenades” for Cancer

(2015) Samuel R. Denmeade et al.   Oncotarget

Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets

(2014) Petr Busek et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

(2014) Koen Jansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior

(2014) B.J. Grindel et al.   MATRIX BIOLOGY

Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells

(2014) A. E. Denton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine xenograft models of human cancer

(2014) W. Nathaniel Brennen et al.   PROSTATE

Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment

(2013) W Nathaniel Brennen et al.   ENDOCRINE-RELATED CANCER

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer

(2013) Julia Tchou et al.   HUMAN PATHOLOGY

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells

(2013) Petra C Schuberth et al.   Journal of Translational Medicine

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-  and Heme Oxygenase-1

(2013) J. N. Arnold et al.   Cancer Immunology Research

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs

(2013) Fiona M. Keane et al.   FEBS Open Bio

Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies

(2012) E. Fischer et al.   CLINICAL CANCER RESEARCH

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

(2012) W. N. Brennen et al.   JNCI-Journal of the National Cancer Institute

Rationale Behind Targeting Fibroblast Activation Protein-Expressing Carcinoma-Associated Fibroblasts as a Novel Chemotherapeutic Strategy

(2012) W. N. Brennen et al.   MOLECULAR CANCER THERAPEUTICS

Injury-Activated Transforming Growth Factor β Controls Mobilization of Mesenchymal Stem Cells for Tissue Remodeling

(2012) Mei Wan et al.   STEM CELLS

Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis

(2011) Omar E. Franco et al.   CANCER RESEARCH

The MSC: An Injury Drugstore

(2011) Arnold I. Caplan et al.   Cell Stem Cell

Evaluation of the tumor targeting of a FAPα-based doxorubicin prodrug

(2011) Sichao Huang et al.   JOURNAL OF DRUG TARGETING

Endothelial α3β1-Integrin Represses Pathological Angiogenesis and Sustains Endothelial-VEGF

(2010) Rita Graça da Silva et al.   AMERICAN JOURNAL OF PATHOLOGY

A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype

(2010) Ruth S. Waterman et al.   PLoS One

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

(2009) Robert M Eager et al.   BMC CANCER

The effect of pH in modulating skin cell behaviour

(2009) J.R. Sharpe et al.   BRITISH JOURNAL OF DERMATOLOGY

Phase II Trial of Talabostat and Docetaxel in Advanced Non-small Cell Lung Cancer

(2009) R.M. Eager et al.   CLINICAL ONCOLOGY

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

(2009) A. M. LeBeau et al.   MOLECULAR CANCER THERAPEUTICS

Fibroblast activation protein α identifies mesenchymal stromal cells from human bone marrow

(2008) Sohyun Bae et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells

(2008) E Spaeth et al.   GENE THERAPY

Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells

(2008) Alanna Kennedy et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel Antibody–4-1BBL Fusion Protein for Targeted Costimulation in Cancer Immunotherapy

(2008) Dafne Müller et al.   JOURNAL OF IMMUNOTHERAPY

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Fibroblast Activation Protein Peptide Substrates Identified from Human Collagen I Derived Gelatin Cleavage Sites†

(2007) Saurabh Aggarwal et al.   BIOCHEMISTRY