The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease

Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke

(2019) Koutarou Nakamura et al.   JOURNAL OF BIOCHEMISTRY

P66Shc signals to age

(2016) Mirella Trinei et al.   Aging-US

Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS)

(2016) Ching-Chyuan Hsieh et al.   Aging-US

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

(2016) C-C Hsieh et al.   Aging-US

Sprouting a new take on stem cell aging

(2012) Joseph T Rodgers et al.   EMBO JOURNAL

Redox Signaling and Cardiac Sarcomeres

(2011) Marius P. Sumandea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

(2010) Christopher Runchel et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanism of Oxidative Stress-Induced ASK1-Catalyzed MKK6 Phosphorylation

(2010) Emmanuel Sturchler et al.   BIOCHEMISTRY

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked?

(2010) John Papaconstantinou et al.   CELL CYCLE

SirT1 in muscle physiology and disease: lessons from mouse models

(2010) M. Vinciguerra et al.   Disease Models & Mechanisms

Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet

(2010) Keiichiro Kataoka et al.   JOURNAL OF HYPERTENSION

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease

(2010) Kuei-Hua Chang et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence

(2009) Anika Grützner et al.   BIOPHYSICAL JOURNAL

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

p66Shc protein, oxidative stress, and cardiovascular complications of diabetes: the missing link

(2009) Pietro Francia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-κB in MPTP-treated mice: implication in Parkinson’s disease

(2009) S. Karunakaran et al.   JOURNAL OF NEUROCHEMISTRY

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

(2008) Anthony J. Donato et al.   AGING CELL

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

Targeting p38-MAPK in the ischaemic heart: kill or cure?

(2008) R BASSI et al.   CURRENT OPINION IN PHARMACOLOGY

Role of TGF-β1-independent changes in protein neosynthesis, p38αMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis

(2008) Aline Chrétien et al.   FREE RADICAL BIOLOGY AND MEDICINE

Olmesartan Prevents Cardiovascular Injury and Hepatic Steatosis in Obesity and Diabetes, Accompanied by Apoptosis Signal Regulating Kinase-1 Inhibition

(2008) Eiichiro Yamamoto et al.   HYPERTENSION

Hypertension Induces Somatic Cellular Senescence in Rats and Humans by Induction of Cell Cycle Inhibitor p16 INK4a

(2008) Jens H. Westhoff et al.   HYPERTENSION

Myosin as a potential redox-sensor: an in vitro study

(2008) Chiara Passarelli et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Selective Activation of p38 Mitogen-Activated Protein Kinase in Dopaminergic Neurons of Substantia Nigra Leads to Nuclear Translocation of p53 in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice

(2008) S. Karunakaran et al.   JOURNAL OF NEUROSCIENCE

Estrogen and SERM neuroprotection in animal models of Parkinson's disease

(2008) Marc Morissette et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction

(2008) Jay C. Sy et al.   NATURE MATERIALS

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY