A Senescence Bystander Effect in Human Lung Fibroblasts

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

(2021) Daryle J. DePianto et al.   JCI Insight

Ageing mechanisms that contribute to tissue remodeling in lung disease

(2021) Michael Schuliga et al.   AGEING RESEARCH REVIEWS

Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner

(2020) Michael Schuliga et al.   CLINICAL SCIENCE

Senescence of IPF Lung Fibroblasts Disrupt Alveolar Epithelial Cell Proliferation and Promote Migration in Wound Healing

(2020) Kaj E. C. Blokland et al.   Pharmaceutics

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

Stuck in a Moment: Does Abnormal Persistence of Epithelial Progenitors Drive Pulmonary Fibrosis?

(2020) Vincent C. Auyeung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts

(2019) David W Waters et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Autocrine IL-1β Mediates the Promotion of Senescent Fibroblasts on Corneal Neovascularization

(2018) Muchen Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts

(2018) Michael Schuliga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Dietary Restriction Ameliorates Age-Related Increase in DNA Damage, Senescence and Inflammation in Mouse Adipose Tissuey

(2017) A. Ishaq et al.   Journal of Nutrition Health & Aging

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

(2017) Lucy A. Murtha et al.   Frontiers in Physiology

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients

(2015) Hagai Yanai et al.   Aging-US

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

(2014) L. Hecker et al.   Science Translational Medicine

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema

(2013) Marco Chilosi et al.   Translational Research

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY