mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

(2020) Md. Abdul Alim Al‐Bari et al.   Annals of the New York Academy of Sciences

Autophagy drives fibroblast senescence through MTORC2 regulation

(2020) Monique Bernard et al.   Autophagy

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The roles of MTOR and miRNAs in endothelial cell senescence

(2020) Eng-Soon Khor et al.   BIOGERONTOLOGY

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

The role of cellular senescence in ageing and endocrine disease

(2020) Sundeep Khosla et al.   Nature Reviews Endocrinology

Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-β/Smad3 signaling in melanoma cells

(2020) Yong Bao et al.   Cell Death & Disease

Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

(2020) Jesús Romero-Pozuelo et al.   Cell Reports

Sequential or Concomitant Inhibition of Cyclin-Dependent Kinase 4/6 Before mTOR Pathway in Hormone-Positive HER2 Negative Breast Cancer: Biological Insights and Clinical Implications

(2020) Giulia Occhipinti et al.   Frontiers in Genetics

Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy

(2020) Tareq Saleh et al.   Cancers

Autophagosome biogenesis and human health

(2020) Tsuyoshi Kawabata et al.   Cell Discovery

Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence

(2020) Raffaella Rastaldo et al.   Frontiers in Cell and Developmental Biology

Senescence as a therapeutically relevant response to CDK4/6 inhibitors

(2020) Verena Wagner et al.   ONCOGENE

The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation

(2020) Nipa H. Patel et al.   RADIATION RESEARCH

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

(2020) Zhi-Ling Li et al.   Nature Communications

Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs

(2020) Hailong Liu et al.   Stem Cell Research & Therapy

Translational control during cellular senescence

(2020) Matthew J. Payea et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular Senescence Variation by Metabolic and Epigenomic Remodeling

(2020) Mitsuyoshi Nakao et al.   TRENDS IN CELL BIOLOGY

Regulation of mTORC2 Signaling

(2020) Wenxiang Fu et al.   Genes

Synergistic anti-cancer activity of CDK4/6 inhibitor palbociclib and dual mTOR kinase inhibitor MLN0128 in pRb-expressing ER-negative breast cancer

(2019) Takuro Yamamoto et al.   BREAST CANCER RESEARCH AND TREATMENT

Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway

(2019) Lin Chen et al.   MEDICAL SCIENCE MONITOR

Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

(2019) Erik S. Knudsen et al.   ONCOGENE

Cellular senescence in bone

(2019) Joshua N. Farr et al.   BONE

PI3K/mTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer

(2019) Kristen Wong et al.   ENDOCRINE-RELATED CANCER

Cellular Senescence: Aging, Cancer, and Injury

(2019) Arianna Calcinotto et al.   PHYSIOLOGICAL REVIEWS

Autophagy-induced senescence is regulated by p38α signaling

(2019) Konstantin Slobodnyuk et al.   Cell Death & Disease

Role of tumor and host autophagy in cancer metabolism

(2019) Laura Poillet-Perez et al.   GENES & DEVELOPMENT

A human tissue‐specific transcriptomic analysis reveals a complex relationship between aging, cancer, and cellular senescence

(2019) Kasit Chatsirisupachai et al.   AGING CELL

Cellular senescence in development, regeneration and disease

(2019) Muriel Rhinn et al.   DEVELOPMENT

The Emerging Roles of mTORC1 in Macromanaging Autophagy

(2019) Akpedje S. Dossou et al.   Cancers

Pleiotropic Effects of mTOR and Autophagy During Development and Aging

(2019) Kathrin Schmeisser et al.   Frontiers in Cell and Developmental Biology

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer

(2019) Vishnu Kumarasamy et al.   ONCOGENE

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents

(2019) Agnieszka Bojko et al.   Cells

mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells

(2019) Theres Schaub et al.   Scientific Reports

Where Metabolism Meets Senescence: Focus on Endothelial Cells

(2019) Jacopo Sabbatinelli et al.   Frontiers in Physiology

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

(2019) Karen Griselda de la Cruz López et al.   Frontiers in Oncology

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy

(2018) Nicola Manzella et al.   AGING CELL

Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma

(2018) Xinhua Song et al.   CLINICAL CANCER RESEARCH

Cellular Senescence-Inducing Small Molecules for Cancer Treatment

(2018) Peng Liu et al.   CURRENT CANCER DRUG TARGETS

Nutrient sensing, growth and senescence

(2018) Bernadette Carroll et al.   FEBS Journal

Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107

(2018) Eng-Soon Khor et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme—Role in Pathogenesis and Therapeutic Perspective

(2018) Elzbieta Pawlowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

The anti-tumor efficacy of CDK4/6 inhibition is enhanced by the combination with PI3K/AKT/mTOR inhibitors through impairment of glucose metabolism in TNBC cells

(2018) Daniele Cretella et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast Cancer

(2018) Chrysiis Michaloglou et al.   MOLECULAR CANCER THERAPEUTICS

CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest

(2018) Shom Goel et al.   TRENDS IN CELL BIOLOGY

Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

(2018) Daniel Asby et al.   Cancer Management and Research

Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice

(2018) Clara Correia-Melo et al.   AGING CELL

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

(2018) Lu Deng et al.   CELL RESEARCH

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Palbociclib-induced autophagy and senescence in gastric cancer cells

(2017) Claudio A. Valenzuela et al.   EXPERIMENTAL CELL RESEARCH

mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells

(2017) Bei Zheng et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

(2017) Bernadette Carroll et al.   JOURNAL OF CELL BIOLOGY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines

(2017) Yoshinari Okada et al.   ONCOLOGY REPORTS

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

Combined Inhibition of CDK4/6 and PI3K/AKT/mTOR Pathways Induces a Synergistic Anti-Tumor Effect in Malignant Pleural Mesothelioma Cells

(2017) Mara A. Bonelli et al.   NEOPLASIA

Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane

(2017) Zongkai Mu et al.   Cell Discovery

Activity-independent targeting of mTOR to lysosomes in primary osteoclasts

(2017) Andrew Wang et al.   Scientific Reports

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

Disease drivers of aging

(2016) Richard J. Hodes et al.   Annals of the New York Academy of Sciences

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Cellular senescence and tumor promotion: Is aging the key?

(2016) Natalia Loaiza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

To clear, or not to clear (senescent cells)? That is the question

(2016) Amaia Lujambio   BIOESSAYS

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

(2016) A. Yoshida et al.   CANCER RESEARCH

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

Morphological and Functional Characteristic of Senescent Cancer Cells

(2016) Ewa Sikora et al.   CURRENT DRUG TARGETS

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

(2016) Kanad Ghosh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An overview of macroautophagy in yeast

(2016) Xin Wen et al.   JOURNAL OF MOLECULAR BIOLOGY

The cell fate: senescence or quiescence

(2016) Menderes Yusuf Terzi et al.   MOLECULAR BIOLOGY REPORTS

Turn up the lysosome

(2016) Paul Saftig et al.   NATURE CELL BIOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Cellular Senescence as the Causal Nexus of Aging

(2016) Naina Bhatia-Dey et al.   Frontiers in Genetics

Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins

(2015) Katherine H. Schreiber et al.   AGING CELL

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

Disruptive chemicals, senescence and immortality

(2015) Amancio Carnero et al.   CARCINOGENESIS

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation

(2015) Sally K. Martin et al.   STEM CELLS

The InflammTORy Powers of Senescence

(2015) Manuel Serrano   TRENDS IN CELL BIOLOGY

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

(2015) Olga V. Leontieva et al.   Oncotarget

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

(2015) Zoe E Gillespie et al.   Nucleus

Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production

(2015) Zoe E Gillespie et al.   Nucleus

Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

(2014) Sylvain Lefort et al.   Autophagy

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Autophagy Inhibition Augments the Anticancer Effects of Epirubicin Treatment in Anthracycline-Sensitive and -Resistant Triple-Negative Breast Cancer

(2014) S. Chittaranjan et al.   CLINICAL CANCER RESEARCH

Getting ready for building: signaling and autophagosome biogenesis

(2014) A. Abada et al.   EMBO REPORTS

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Doxorubicin induces senescence and impairs function of human cardiac progenitor cells

(2013) Elena Piegari et al.   BASIC RESEARCH IN CARDIOLOGY

A growing role for mTOR in promoting anabolic metabolism

(2013) Jessica J. Howell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

(2013) Ariel Pribluda et al.   CANCER CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Rapamycin induces pluripotent genes associated with avoidance of replicative senescence

(2013) Tatyana V. Pospelova et al.   CELL CYCLE

A Central Role for mTOR in Lipid Homeostasis

(2013) Dudley W. Lamming et al.   Cell Metabolism

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy and senescence in cancer therapy

(2013) David A. Gewirtz   JOURNAL OF CELLULAR PHYSIOLOGY

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Cyclin D1 Activity Regulates Autophagy and Senescence in the Mammary Epithelium

(2012) N. E. Brown et al.   CANCER RESEARCH

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Mechanisms and regulation of autophagosome formation

(2012) Claudine Kraft et al.   CURRENT OPINION IN CELL BIOLOGY

Cancer cell senescence: a new frontier in drug development

(2012) Claire J. Cairney et al.   DRUG DISCOVERY TODAY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

(2012) Bruno Bernardes de Jesus et al.   EMBO Molecular Medicine

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Regulation of the autophagy initiating kinase ULK1 by nutrients: Roles of mTORC1 and AMPK

(2011) Joungmok Kim et al.   CELL CYCLE

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Shifting senescence into quiescence by turning up p53

(2010) Manuel Serrano   CELL CYCLE

Weak p53 permits senescence during cell cycle arrest

(2010) Olga V. Leontieva et al.   CELL CYCLE

Lysosomal Rag-ulation of mTOR Complex 1 Activity

(2010) Robert T. Abraham   Cell Metabolism

Autophagy and misfolded proteins in neurodegeneration

(2010) Daniel J. Metcalf et al.   EXPERIMENTAL NEUROLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

(2010) Akiko Kuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence

(2009) Peter D. Adams   MOLECULAR CELL

Common corruption of the mTOR signaling network in human tumors

(2009) S Menon et al.   ONCOGENE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL