Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics

A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy

(2017) Mei-Rong Ke et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A synthetic urinary probe–coated nanoparticles sensitive to fibroblast activation protein α for solid tumor diagnosis

(2017) Xinwei Feng et al.   International Journal of Nanomedicine

Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein

(2017) Petra Dvořáková et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity

(2017) Li-Juan Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Biomarkers in Tumor Microenvironment? Upregulation of Fibroblast Activation Protein-α Correlates with Gastric Cancer Progression and Poor Prognosis

(2017) Mengmou Hu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Fibroblast Activation Protein-α-Positive Fibroblasts Promote Gastric Cancer Progression and Resistance to Immune Checkpoint Blockade

(2017) Xuyang Wen et al.   ONCOLOGY RESEARCH

The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases

(2017) Peio Errarte et al.   PLoS One

Selective Homogeneous Assay for Circulating Endopeptidase Fibroblast Activation Protein (FAP)

(2017) Travis W. Bainbridge et al.   Scientific Reports

Ultrasensitive Fluorescent Probes Reveal an Adverse Action of Dipeptide Peptidase IV and Fibroblast Activation Protein during Proliferation of Cancer Cells

(2016) Qiuyu Gong et al.   ANALYTICAL CHEMISTRY

A specific, transmembrane interface regulates fibroblast activation protein (FAP) homodimerization, trafficking and exopeptidase activity

(2016) Benjamaporn Wonganu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Potential of activatable FAP-targeting immunoliposomes in intraoperative imaging of spontaneous metastases

(2016) Felista L. Tansi et al.   BIOMATERIALS

Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma

(2016) Cheol Keun Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Anti-tumor effects of DNA vaccine targeting human fibroblast activation protein α by producing specific immune responses and altering tumor microenvironment in the 4T1 murine breast cancer model

(2016) Qiu Xia et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1

(2016) Young-Jin Park et al.   CANCER LETTERS

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Improvement of anti-tumor immunity of fibroblast activation protein α based vaccines by combination with cyclophosphamide in a murine model of breast cancer

(2016) Qiu Xia et al.   CELLULAR IMMUNOLOGY

Expression of the FAP gene in non-fibroblast human cell lines. Development of cancer-associated fibroblast models

(2016) D. V. Tyulkina et al.   Doklady Biochemistry and Biophysics

GPR30 Promotes Prostate Stromal Cell Activation via Suppression of ERα Expression and Its Downstream Signaling Pathway

(2016) Bona Jia et al.   ENDOCRINOLOGY

Fibroblast activation protein predicts prognosis in clear cell renal cell carcinoma

(2016) José I. López et al.   HUMAN PATHOLOGY

Cyclophosphamide enhances anti-tumor effects of a fibroblast activation protein α-based DNA vaccine in tumor-bearing mice with murine breast carcinoma

(2016) Qiu Xia et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21

(2016) Diana Ronai Dunshee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis

(2016) P. Bru nker et al.   MOLECULAR CANCER THERAPEUTICS

Targeting of cancer-associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment

(2016) MINMIN LI et al.   Molecular Medicine Reports

Reversal of liver cancer-associated stellate cell-induced stem-like characteristics in SMMC-7721 cells by 8-bromo-7-methoxychrysin via inhibiting STAT3 activation

(2016) YINGHONG CUI et al.   ONCOLOGY REPORTS

Increased tissue and circulating levels of dipeptidyl peptidase-IV enzymatic activity in patients with pancreatic ductal adenocarcinoma

(2016) Petr Busek et al.   PANCREATOLOGY

Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

(2016) Anna Mazur et al.   PLoS One

Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy

(2016) Emmanuel S. Akinboye et al.   PROSTATE

Scaffold-Free Coculture Spheroids of Human Colonic Adenocarcinoma Cells and Normal Colonic Fibroblasts Promote Tumorigenicity in Nude Mice

(2016) Jong-il Park et al.   Translational Oncology

Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma

(2016) Petr Busek et al.   TUMOR BIOLOGY

Immunization of stromal cell targeting fibroblast activation protein providing immunotherapy to breast cancer mouse model

(2016) Mingyao Meng et al.   TUMOR BIOLOGY

Enhancement of fibroblast activation protein α-based vaccines and adenovirus boost immunity by cyclophosphamide through inhibiting IL-10 expression in 4T1 tumor bearing mice

(2016) Qiu Xia et al.   VACCINE

TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts

(2016) Dominika Wolczyk et al.   CELLULAR ONCOLOGY

Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression

(2016) Claudia Sorrentino et al.   Oncotarget

Selective Activation of Anticancer Chemotherapy by Cancer-Associated Fibroblasts in the Tumor Microenvironment

(2016) Mi-Gyeong Kim et al.   JNCI-Journal of the National Cancer Institute

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

(2016) Amanda M. Ackermann et al.   Molecular Metabolism

A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma

(2016) Jinxu Fang et al.   Molecular Therapy-Oncolytics

Human FGF-21 Is a Substrate of Fibroblast Activation Protein

(2016) Andrew L. Coppage et al.   PLoS One

Specific inhibition of fibroblast activation protein (FAP)-alpha prevents tumor progression in vitro

(2015) Volker Teichgräber et al.   Advances in Medical Sciences

Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation

(2015) Tianjiao Ji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Integral membrane protease fibroblast activation protein sensitizes fibrosarcoma to chemotherapy and alters cell death mechanisms

(2015) Sarah K. Baird et al.   APOPTOSIS

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

(2015) E. Y. Zhen et al.   BIOCHEMICAL JOURNAL

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia

(2015) Julia D. Knopf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fibroblast activation protein-α-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma

(2015) Tomoya Kawase et al.   BMC GASTROENTEROLOGY

Differential expression of cancer-associated fibroblast-related proteins according to molecular subtype and stromal histology in breast cancer

(2015) Sung Yeon Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Fibroblast activation protein increases metastatic potential of fibrosarcoma line HT1080 through upregulation of integrin-mediated signaling pathways

(2015) Sarah K. Baird et al.   CLINICAL & EXPERIMENTAL METASTASIS

Evaluation of a 5-Marker Blood Test for Colorectal Cancer Early Detection in a Colorectal Cancer Screening Setting

(2015) S. Werner et al.   CLINICAL CANCER RESEARCH

Treatment monitoring of patients with epithelial ovarian cancer using invasive circulating tumor cells (iCTCs)

(2015) Michael L. Pearl et al.   GYNECOLOGIC ONCOLOGY

A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice

(2015) Jinxu Fang et al.   INTERNATIONAL JOURNAL OF CANCER

Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice

(2015) Ming-Hui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously

(2015) Markus Rabenhold et al.   JOURNAL OF CONTROLLED RELEASE

Fibroblast activation protein and its prognostic significance in correlation with vascular endothelial growth factor in pancreatic adenocarcinoma

(2015) DIMITRIOS PATSOURAS et al.   Molecular Medicine Reports

Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review)

(2015) FUMING ZI et al.   Molecular Medicine Reports

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

(2015) M.M. Koczorowska et al.   Molecular Oncology

Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer

(2015) Yoon Yang Jung et al.   TUMOR BIOLOGY

Expression levels of seprase/FAPα and DPPIV/CD26 in epithelial ovarian carcinoma

(2015) MENGZHEN ZHANG et al.   Oncology Letters

Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

(2015) Kenneth W. Jackson et al.   NEOPLASIA

Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy

(2015) Ting Huang et al.   Molecular Therapy-Oncolytics

A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts

(2015) Meihua Chen et al.   Scientific Reports

A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation

(2014) Brenna Osborne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

FAP-α (Fibroblast activation protein-α) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway

(2014) Jun Jia et al.   BMC CELL BIOLOGY

Fibroblast activation protein protects bortezomib-induced apoptosis in multiple myeloma cells through β-catenin signaling pathway

(2014) Fu-Ming Zi et al.   CANCER BIOLOGY & THERAPY

miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors

(2014) C. Gong et al.   CANCER RESEARCH

Tumour-associated fibroblasts contribute to neoangiogenesis in human parathyroid neoplasia

(2014) C Verdelli et al.   ENDOCRINE-RELATED CANCER

Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets

(2014) Petr Busek et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Transcriptional Regulation of Seprase in Invasive Melanoma Cells by Transforming Growth Factor-β Signaling

(2014) Shaun Tulley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast phenotypes in different lung diseases

(2014) Heng Du et al.   Journal of Cardiothoracic Surgery

In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes

(2014) Ronny Rüger et al.   JOURNAL OF CONTROLLED RELEASE

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

(2014) Koen Jansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior

(2014) B.J. Grindel et al.   MATRIX BIOLOGY

Estrogen biology: New insights into GPER function and clinical opportunities

(2014) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Rapid fibroblast activation in mammalian cells induced by silicon nanowire arrays

(2014) Qing Ha et al.   Nanoscale

Upregulated expression and activation of membrane-associated proteases in esophageal squamous cell carcinoma

(2014) KATARZYNA AUGOFF et al.   ONCOLOGY REPORTS

Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine xenograft models of human cancer

(2014) W. Nathaniel Brennen et al.   PROSTATE

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

(2014) Elizabeth J. Hamson et al.   Proteomics Clinical Applications

Tumor-associated mesothelial cells are negative prognostic factors in gastric cancer and promote peritoneal dissemination of adherent gastric cancer cells by chemotaxis

(2014) Zhi-Feng Miao et al.   TUMOR BIOLOGY

Impact of fibroblast activation protein on osteosarcoma cell lines in vitro

(2014) LIXIANG DING et al.   Oncology Letters

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer

(2013) Julia Tchou et al.   HUMAN PATHOLOGY

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

Estrogen-mediated activation of fibroblasts and its effects on the fibroid cell proliferation

(2013) Ning Luo et al.   Translational Research

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Tumoral Immune Suppression by Macrophages Expressing Fibroblast Activation Protein-  and Heme Oxygenase-1

(2013) J. N. Arnold et al.   Cancer Immunology Research

Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires

(2012) Shu-Wen Kuo et al.   BIOMATERIALS

Fibroblast Activation Protein in Remodeling Tissues

(2012) M. Jacob et al.   CURRENT MOLECULAR MEDICINE

Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α

(2011) Fiona M. Keane et al.   FEBS Journal

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

(2009) Robert M Eager et al.   BMC CANCER

Phase II Trial of Talabostat and Docetaxel in Advanced Non-small Cell Lung Cancer

(2009) R.M. Eager et al.   CLINICAL ONCOLOGY

Cell Adhesion and Spreading Behavior on Vertically Aligned Silicon Nanowire Arrays

(2008) Suijian Qi et al.   ACS Applied Materials & Interfaces

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

(2008) E. Ostermann et al.   CLINICAL CANCER RESEARCH