Telomeres and telomerase in prostate cancer development and therapy

G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells

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The genomic characteristics and cellular origin of chromothripsis

(2016) Zuzana Storchová et al.   CURRENT OPINION IN CELL BIOLOGY

Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages

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Androgen receptor targeted therapies in castration-resistant prostate cancer: Bench to clinic

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The shelterin complex and hematopoiesis

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Inflammatory mediators in the development and progression of benign prostatic hyperplasia

(2016) Cosimo De Nunzio et al.   Nature Reviews Urology

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Structural and functional association of androgen receptor with telomeres in prostate cancer cells

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Chromothripsis and Kataegis Induced by Telomere Crisis

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Integrative Clinical Genomics of Advanced Prostate Cancer

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DNA damage foci: Meaning and significance

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ATM Inhibition Potentiates Death of Androgen Receptor-inactivated Prostate Cancer Cells with Telomere Dysfunction

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Widespread telomere instability in prostatic lesions

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Telomerase activation by genomic rearrangements in high-risk neuroblastoma

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Cell death during crisis is mediated by mitotic telomere deprotection

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TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

(2015) Linda J Valentijn et al.   NATURE GENETICS

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia

(2015) Gabriela M. Baerlocher et al.   NEW ENGLAND JOURNAL OF MEDICINE

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Frequency of TERT Promoter Mutations in Prostate Cancer

(2015) Robert Stoehr et al.   PATHOBIOLOGY

Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial

(2015) Christopher M. Heaphy et al.   PROSTATE

GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stress

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Telomere biology: Rationale for diagnostics and therapeutics in cancer

(2015) Philippe Rousseau et al.   RNA Biology

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

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Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

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A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer

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Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial

(2014) B. Gurel et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Aspirin, NSAIDs, and Risk of Prostate Cancer: Results from the REDUCE Study

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Telomere-Dependent Genomic Integrity: Evolution of the Fusion-Bridge-Breakage Cycle Concept

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Overdiagnosis and Overtreatment of Prostate Cancer

(2014) Stacy Loeb et al.   EUROPEAN UROLOGY

Circulating tumor cell telomerase activity as a prognostic marker for overall survival in SWOG 0421: A phase III metastatic castration resistant prostate cancer trial

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Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

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Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT

(2014) Linghe Xi et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex interacting small molecules and drugs: from bench toward bedside

(2014) Sebastian Müller et al.   Expert Review of Clinical Pharmacology

Reactive Oxygen Species in Inflammation and Tissue Injury

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Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms

(2013) A. Malhotra et al.   GENOME RESEARCH

Tracking the clonal origin of lethal prostate cancer

(2013) Michael C. Haffner et al.   JOURNAL OF CLINICAL INVESTIGATION

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

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No end in sight for telomerase-targeted cancer drugs

(2013) Sarah C P Williams   NATURE MEDICINE

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Repair at Telomeres: Keeping the Ends Intact

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Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

Prostate Cancer Cell Telomere Length Variability and Stromal Cell Telomere Length as Prognostic Markers for Metastasis and Death

(2013) C. M. Heaphy et al.   Cancer Discovery

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Assays for human telomerase activity: progress and prospects

(2012) Xiaoming Zhou et al.   CHEMICAL SOCIETY REVIEWS

Poly-gene fusion transcripts and chromothripsis in prostate cancer

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Protection against oxidative DNA damage and stress in human prostate by glutathioneS-transferase P1

(2012) Rajnee Kanwal et al.   MOLECULAR CARCINOGENESIS

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells

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Cancer and Telomeres--An ALTernative to Telomerase

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Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

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Prostate cancer and inflammation: the evidence

(2011) Karen S Sfanos et al.   HISTOPATHOLOGY

Prostatic Inflammation Detected in Initial Biopsy Specimens and Urinary Pyuria are Predictors of Negative Repeat Prostate Biopsy

(2011) Kazutoshi Fujita et al.   JOURNAL OF UROLOGY

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(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference

(2011) Tong Xu et al.   PROSTATE

Aggressiveness of Inflammation in Histological Prostatitis – Correlation with Total and Free Prostate Specific Antigen Levels in Men with Biochemical Criteria for Prostate Biopsy

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Alternative Lengthening of Telomeres in Human Glioma Stem Cells

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Sizing the ends: Normal length of human telomeres

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A Cancer Detection Platform Which Measures Telomerase Activity from Live Circulating Tumor Cells Captured on a Microfilter

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Anti-inflammatory activity of soy and tea in prostate cancer prevention

(2010) Anna Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Androgen Receptor Interacts with Telomeric Proteins in Prostate Cancer Cells

(2010) Sahn-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase as an Important Target of Androgen Signaling Blockade for Prostate Cancer Treatment

(2010) S. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression

(2010) Samuel Beck et al.   MOLECULES AND CELLS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

(2009) John Nemunaitis et al.   MOLECULAR THERAPY

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

(2009) Anthony J Cesare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mortality Results from a Randomized Prostate-Cancer Screening Trial

(2009) Gerald L. Andriole et al.   NEW ENGLAND JOURNAL OF MEDICINE

Screening and Prostate-Cancer Mortality in a Randomized European Study

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Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer

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Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model

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Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes

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Evaluation of Prostatitis in Autopsied Prostates—Is Chronic Inflammation More Associated With Benign Prostatic Hyperplasia or Cancer?

(2008) Nicolas B. Delongchamps et al.   JOURNAL OF UROLOGY

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

The Relationship between Prostate Inflammation and Lower Urinary Tract Symptoms: Examination of Baseline Data from the REDUCE Trial

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Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development

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