Senotherapeutics in Cancer and HIV

Programmed Cell Senescence in the Mouse Developing Spinal Cord and Notochord

(2021) Jorge Antolio Domínguez-Bautista et al.   Frontiers in Cell and Developmental Biology

Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults with HIV

(2021) Vincent C Marconi et al.   CLINICAL INFECTIOUS DISEASES

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

(2021) Delphine Planas et al.   EBioMedicine

Senolytics and Senomorphics: natural and synthetic therapeutics in the treatment of aging and chronic diseases

(2021) Sofia M. Lagoumtzi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

(2021) Cecilia R. Chambers et al.   Molecular Oncology

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency

(2021) Lesley R. de Armas et al.   Frontiers in Immunology

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

(2021) Ibrahim Mohammed et al.   Frontiers in Endocrinology

Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice

(2021) Stefano Tarantini et al.   GeroScience

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

(2021) Hillary H. Le et al.   EBioMedicine

Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis

(2021) Jingshu Meng et al.   JCI Insight

FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice

(2020) Chi Zhang et al.   Aging-US

The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes

(2020) Audrey Griveau et al.   AGING CELL

Senotherapeutics and HIV-1 Persistence

(2020) Matthew A. Szaniawski et al.   Current HIV/AIDS Reports

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Recent update on discovery and development of Hsp90 inhibitors as senolytic agents

(2020) Sayan Dutta Gupta et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Impact of HIV infection on aging and immune status

(2020) Jose-Ramon Blanco et al.   Expert Review of Anti-Infective Therapy

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

HIV controllers have low inflammation associated with a strong HIV-specific immune response in blood

(2019) Hakim Hocini et al.   JOURNAL OF VIROLOGY

Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy

(2019) Aaron Christensen-Quick et al.   JOURNAL OF VIROLOGY

Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance

(2019) Serena Spudich et al.   JOURNAL OF CLINICAL INVESTIGATION

The HIV Reservoir in Monocytes and Macrophages

(2019) Michelle E. Wong et al.   Frontiers in Immunology

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Operational durability of three-dimensional Ni-Fe layered double hydroxide electrocatalyst for water oxidation

(2019) Seyeong Lee et al.   ELECTROCHIMICA ACTA

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence

(2019) Aswath P. Chandrasekar et al.   CLINICAL MICROBIOLOGY REVIEWS

Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro

(2019) Christina Gavegnano et al.   Journal of Neuroinflammation

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Senotherapeutics for HIV and aging

(2019) Matthew A. Szaniawski et al.   Current Opinion in HIV and AIDS

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer

(2018) Kirsten K. Ness et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrating the DNA damage and protein stress responses during cancer development and treatment

(2018) Vassilis G Gorgoulis et al.   JOURNAL OF PATHOLOGY

Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection

(2018) Natalie C Chen et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Is DNA damage indispensable for stress-induced senescence?

(2018) Anna Bielak-Zmijewska et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

(2018) Hannah Walters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence and senotherapeutics: a new field in cancer therapy

(2018) Vassilios Myrianthopoulos et al.   PHARMACOLOGY & THERAPEUTICS

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Senescent cells: A new Achilles’ heel to exploit for cancer medicine?

(2018) Boyi Zhang et al.   AGING CELL

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition

(2017) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis

(2017) Eleni Mavrogonatou et al.   MATRIX BIOLOGY

Inflammaging and human longevity in the omics era

(2017) Daniela Monti et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

(2017) Lisa Giulino-Roth et al.   MOLECULAR CANCER THERAPEUTICS

Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB

(2017) Xinyi Yang et al.   Molecular Medicine Reports

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Correction: p16INK4a Expression and Immunologic Aging in Chronic HIV Infection

(2017) Susan Pereira Ribeiro et al.   PLoS One

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

(2017) Jose Mario Gonzalez-Meljem et al.   Nature Communications

A Novel Indication for Panobinostat as a Senolytic Drug in NSCLC and HNSCC

(2017) Leleesha Samaraweera et al.   Scientific Reports

Robust, universal biomarker assay to detect senescent cells in biological specimens

(2016) Konstantinos Evangelou et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells

(2016) Mercedes Bermejo et al.   BIOCHEMICAL PHARMACOLOGY

Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice

(2016) Huairui Shi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Microbiome alterations in HIV infection a review

(2016) Brett Williams et al.   CELLULAR MICROBIOLOGY

Dasatinib: A Review in Chronic Myeloid Leukaemia and Ph+ Acute Lymphoblastic Leukaemia

(2016) Gillian M. Keating   DRUGS

Energetic interventions for healthspan and resiliency with aging

(2016) Derek M. Huffman et al.   EXPERIMENTAL GERONTOLOGY

Inhibition of Heat Shock Protein 90 Prevents HIV Rebound

(2016) Pheroze Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling

(2016) J. Li et al.   MOLECULAR CANCER THERAPEUTICS

p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion

(2016) Aharon Helman et al.   NATURE MEDICINE

mTORC1 and mTORC2 in cancer and the tumor microenvironment

(2016) L C Kim et al.   ONCOGENE

Derepression ofhTERTgene expression promotes escape from oncogene-induced cellular senescence

(2016) Priyanka L. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

The histone deacetylase inhibitor panobinostat lowers biomarkers of cardiovascular risk and inflammation in HIV patients

(2015) Anne Sofie Høgh Kølbæk Kjær et al.   AIDS

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Reduction of HIV Persistence Following Transplantation in HIV-Infected Kidney Transplant Recipients

(2014) P. G. Stock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro

(2014) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients With Breast Cancer

(2014) Hanna K. Sanoff et al.   JNCI-Journal of the National Cancer Institute

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Resveratrol: Therapeutic Potential for Improving Cardiometabolic Health

(2013) R. M. Pollack et al.   AMERICAN JOURNAL OF HYPERTENSION

Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention

(2013) Ansgar Bruning   Anti-Cancer Agents in Medicinal Chemistry

Clinical Ascertainment of Health Outcomes Among Adults Treated for Childhood Cancer

(2013) Melissa M. Hudson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antiretroviral Therapy Initiated Within 6 Months of HIV Infection Is Associated With Lower T-Cell Activation and Smaller HIV Reservoir Size

(2013) Vivek Jain et al.   JOURNAL OF INFECTIOUS DISEASES

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Transmitting senescence to the cell neighbourhood

(2013) Matthew Hoare et al.   NATURE CELL BIOLOGY

Inhibition of Plk1 and Cyclin B1 Expression Results in Panobinostat-Induced G2 Delay and Mitotic Defects

(2013) Michael Prystowsky et al.   Scientific Reports

Expression ofp16INK4aas a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

(2012) Julie A. E. Nelson et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Tanespimycin as Antitumor Therapy

(2012) Meletios-Athanassios Dimopoulos et al.   Clinical Lymphoma Myeloma & Leukemia

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium

(2012) Beamon Agarwal et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

HIV and Aging

(2012) Kevin P. High et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Chronic Resveratrol Treatment Ameliorates Cell Adhesion and Mitigates the Inflammatory Phenotype in Senescent Human Fibroblasts

(2012) V. Pitozzi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population

(2011) G. Guaraldi et al.   CLINICAL INFECTIOUS DISEASES

Dietary flavonoid fisetin targets caspase-3-deficient human breast cancer MCF-7 cells by induction of caspase-7-associated apoptosis and inhibition of autophagy

(2011) Shu-Jun Chiu   INTERNATIONAL JOURNAL OF ONCOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2

(2011) Giorgio Mangino et al.   PLoS One

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Developing a minimum standard of care for treating people with osteoarthritis of the hip and knee

(2010) Lyn March et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

Cellular signaling perturbation by natural products

(2009) Fazlul H. Sarkar et al.   CELLULAR SIGNALLING

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY