The Contribution of Lysosomes to DNA Replication

Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2

(2021) Zhuangzhuang Zhao et al.   CELL CALCIUM

Mitophagy in tumorigenesis and metastasis

(2021) Logan P. Poole et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Causes and consequences of micronuclei

(2021) Ksenia Krupina et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy and autophagy-related proteins in cancer

(2020) Xiaohua Li et al.   Molecular Cancer

Ligand-based discovery of small molecules suppressing cancer cell proliferation via autophagic flux inhibition

(2020) Li Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A predictable conserved DNA base composition signature defines human core DNA replication origins

(2020) Ildem Akerman et al.   Nature Communications

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Regulation of replication fork speed: Mechanisms and impact on genomic stability

(2019) Joanna Maria Merchut-Maya et al.   DNA REPAIR

Autophagy role(s) in response to oncogenes and DNA replication stress

(2019) Riccardo Vanzo et al.   CELL DEATH AND DIFFERENTIATION

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

(2019) Therese Wilhelm et al.   Nature Communications

Genome-wide identification of 99 autophagy-related ( Atg ) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium

(2018) Hye-Min Kang et al.   AQUATIC TOXICOLOGY

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Mitochondria, lysosomes and dysfunction: their meaning in neurodegeneration

(2018) Matteo Audano et al.   JOURNAL OF NEUROCHEMISTRY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

SAMHD1 and the innate immune response to cytosolic DNA during DNA replication

(2018) Flavie Coquel et al.   CURRENT OPINION IN IMMUNOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

(2017) Natasha Emmanuel et al.   Cell Reports

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

(2017) Gerta Hoxhaj et al.   Cell Reports

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

(2017) Sandra Torres et al.   Frontiers in Physiology

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

(2016) Panagiotis Galanos et al.   NATURE CELL BIOLOGY

Spatial colocalization and functional link of purinosomes with mitochondria

(2016) J. B. French et al.   SCIENCE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

(2016) Anne-Marie Ellegaard et al.   EBioMedicine

Single-cell analysis challenges the connection between autophagy and senescence induced by DNA damage

(2015) Eduardo Cremonese Filippi-Chiela et al.   Autophagy

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Recent insights into cell death and autophagy

(2015) Brent E. Fitzwalter et al.   FEBS Journal

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

(2015) Katsunori Hase et al.   NUCLEIC ACIDS RESEARCH

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast

(2014) H. Huang et al.   EMBO JOURNAL

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

mTORC1 signaling controls multiple steps in ribosome biogenesis

(2014) Valentina Iadevaia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy

(2014) Yuk Yuen Lan et al.   Cell Reports

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Direct uptake and degradation of DNA by lysosomes

(2013) Yuuki Fujiwara et al.   Autophagy

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

(2013) E. Karanasios et al.   JOURNAL OF CELL SCIENCE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

Macroautophagy-aided elimination of chromatin

(2012) Jekaterina Erenpreisa et al.   Autophagy

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

The endosome–lysosome pathway and information generation in the immune system

(2011) Colin Watts   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Autophagy-Dependent Regulation of the DNA Damage Response Protein Ribonucleotide Reductase 1

(2011) M. Dyavaiah et al.   MOLECULAR CANCER RESEARCH

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation

(2008) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE