Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

Hallmarks of aging: An expanding universe

(2023) Carlos López-Otín et al.   CELL

DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling

(2023) Ke Zhang et al.   Cell Reports

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

(2023) Kyi Mar Wai et al.   Frontiers in Public Health

Effects of antimony exposure on DNA damage and genome-wide variation in zebrafish (Danio rerio) liver

(2023) Qin Yao et al.   AQUATIC TOXICOLOGY

Hallmarks of neurodegenerative diseases

(2023) David M. Wilson et al.   CELL

miR-186 induces tetraploidy in arsenic exposed human keratinocytes

(2023) Ana P. Ferragut Cardoso et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Yeast chaperones and ubiquitin ligases contribute to proteostasis during arsenite stress by preventing or clearing protein aggregates

(2023) Joana I. Rodrigues et al.   FEBS LETTERS

DNA Damage-Mediated Neurotoxicity in Parkinson’s Disease

(2023) Zhong-Xuan Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Liquid–Liquid Phase Separation in Actin Polymerization

(2023) Olga Povarova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Taking Charge: Metal Ions Accelerate Amyloid Aggregation in Sequence Variants of α-Synuclein

(2023) Emily J. Byrd et al.   Journal of the American Society for Mass Spectrometry

Phase separation on microtubules: from droplet formation to cellular function?

(2023) Vladimir A. Volkov et al.   TRENDS IN CELL BIOLOGY

An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications

(2023) Yanan Jiang et al.   Cell Death Discovery

Arsenic in medicine: past, present and future

(2022) Ngozi P. Paul et al.   BIOMETALS

Compartmentalization of telomeres through DNA-scaffolded phase separation

(2022) Amanda Jack et al.   DEVELOPMENTAL CELL

Differential metabolism of arsenicals regulates Fps1-mediated arsenite transport

(2022) Jongmin Lee et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease

(2022) Gwyneth Welch et al.   EMBO REPORTS

STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy

(2022) Jared T. Hinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

(2022) Lisa Zuily et al.   mBio

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

(2022) Wouter Huiting et al.   eLife

High and stable ATP levels prevent aberrant intracellular protein aggregation in yeast

(2022) Masak Takaine et al.   eLife

Molecular Link between DNA Damage Response and Microtubule Dynamics

(2022) Jung Min Kim   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

26S proteasomes become stably activated upon heat shock when ubiquitination and protein degradation increase

(2022) Donghoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson’s disease and other synucleinopathies

(2022) Pedro Magalhães et al.   npj Parkinsons Disease

The 28-day repeated arsenic exposure increases tau phosphorylation in the rat brain

(2022) Churaibhon Wisessaowapak et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response

(2022) Laura Vanderwaeren et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrating transcriptome and physiological analysis to reveal the essential responses of Daphnia magna to antimony trioxide nanoparticle

(2022) Jihai Gu et al.   JOURNAL OF HAZARDOUS MATERIALS

Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response

(2022) Surabhi Chowdhary et al.   MOLECULAR CELL

Impacts of arsenic on Rad18 and translesion synthesis

(2022) L.B. Volk et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The DNA damage checkpoint: A tale from budding yeast

(2022) Paolo Pizzul et al.   Frontiers in Genetics

Differential contributions of the proteasome, autophagy, and chaperones to the clearance of arsenite-induced protein aggregates in yeast

(2022) Sansan Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents

(2022) Thomas Rico et al.   Cancers

Arsenic: A Global Environmental Challenge

(2021) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

(2021) Ji-Hoon Lee et al.   MOLECULAR CELL

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single molecule microscopy reveals key physical features of repair foci in living cells

(2021) Judith Miné-Hattab et al.   eLife

Redox Regulation of the Actin Cytoskeleton in Cell Migration and Adhesion: On the Way to a Spatiotemporal View

(2021) Emre Balta et al.   Frontiers in Cell and Developmental Biology

Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling

(2021) Munir Ozturk et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2

(2021) Churaibhon Wisessaowapak et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

(2021) Ireneusz Litwin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity

(2021) Stefanie Andersson et al.   JOURNAL OF CELL SCIENCE

Functional and structural characterization of AntR, an Sb(III) responsive transcriptional repressor

(2021) Thiruselvam Viswanathan et al.   MOLECULAR MICROBIOLOGY

Mode of action assessment of the genotoxic properties of antimony and its compounds evaluated in the ToxTracker assay

(2021) Craig J. Boreiko et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins

(2021) Xixi Zhou et al.   SEMINARS IN CANCER BIOLOGY

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

(2021) Anna Ainslie et al.   Open Biology

Increased prevalence of Parkinson's disease in soils with high arsenic levels

(2021) Chien-Pang Lee et al.   PARKINSONISM & RELATED DISORDERS

Arsenic methylation – Lessons from three decades of research

(2021) David J. Thomas   TOXICOLOGY

Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

(2021) Tanima SenGupta et al.   Cell Reports

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

(2021) Md. Ataur Rahman et al.   Toxics

Biomolecular condensates at sites of DNA damage: More than just a phase

(2021) Vincent Spegg et al.   DNA REPAIR

Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells

(2021) Emma Lorentzon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arsenic-protein interactions as a mechanism of arsenic toxicity

(2021) Cristian A. Vergara-Gerónimo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

DNA repair by Rad52 liquid droplets

(2020) Roxanne Oshidari et al.   Nature Communications

The Role of Reactive Oxygen Species in Arsenic Toxicity

(2020) Yuxin Hu et al.   Biomolecules

Arsenic Exposure and Compromised Protein Quality Control

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

XPA: DNA Repair Protein of Significant Clinical Importance

(2020) Lucia Borszéková Pulzová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Positive association between soil arsenic concentration and mortality from alzheimer’s disease in mainland China

(2020) Xue-Lian Li et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Global threat of arsenic in groundwater

(2020) Joel Podgorski et al.   SCIENCE

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Associations between blood arsenic and urinary arsenic species concentrations as an exposure characterization tool

(2020) Yuko Takayama et al.   SCIENCE OF THE TOTAL ENVIRONMENT

LRRK2 Phosphorylation, More Than an Epiphenomenon

(2020) Antoine Marchand et al.   Frontiers in Neuroscience

Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan

(2020) Stephany Francisco et al.   AGEING RESEARCH REVIEWS

Arsenic trioxide as a novel anti-glioma drug: a review

(2020) Yi Fang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

(2020) Nidheesh Thadathil et al.   MOLECULAR NEUROBIOLOGY

The effects of antimony on Alzheimer’s disease-like pathological changes in mice brain

(2020) Shenya Xu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Antimony and its compounds: Health impacts related to pulmonary toxicity, cancer, and genotoxicity

(2020) Craig J. Boreiko et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic contamination of groundwater: A global synopsis with focus on the Indian Peninsula

(2020) E. Shaji et al.   Geoscience Frontiers

The role of H3K9me2 ‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba extract intervention

(2020) Xuejiao Ding et al.   ENVIRONMENTAL TOXICOLOGY

Activation of Lrrk2 and α-Synuclein in substantia nigra, striatum, and cerebellum after chronic exposure to arsenite

(2020) Zuzana Drobna   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tau and DNA Damage in Neurodegeneration

(2020) Luca Colnaghi et al.   Brain Sciences

Metals and Mechanisms of Carcinogenesis

(2019) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The proteostasis network and its decline in ageing

(2019) Mark S. Hipp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeted Degradation of Glucose Transporters Protects Against Arsenic Toxicity

(2019) Marco Jochem et al.   MOLECULAR AND CELLULAR BIOLOGY

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

Selective Hsp70-Dependent Docking of Hsp104 to Protein Aggregates Protects the Cell from the Toxicity of the Disaggregase

(2019) Tomasz Chamera et al.   JOURNAL OF MOLECULAR BIOLOGY

Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation

(2019) Xixi Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

(2019) Rui Gao et al.   eLife

Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin

(2019) Laura Mediani et al.   EMBO JOURNAL

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases

(2019) T. Maiuri et al.   Neurotherapeutics

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

(2019) Dechao Cao et al.   Frontiers in Immunology

Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway

(2019) Xiaoke Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

Nuclear actin filaments in DNA repair dynamics

(2019) Christopher Patrick Caridi et al.   NATURE CELL BIOLOGY

Overexpression of hsa-miR-186 induces chromosomal instability in arsenic-exposed human keratinocytes

(2019) Jiguo Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Thiol-based direct threat sensing by the stress-activated protein kinase Hog1

(2019) Angel Guerra-Moreno et al.   Science Signaling

Biomolecular condensates in neurodegeneration and cancer

(2019) Stephanie Spannl et al.   TRAFFIC

Risk of Cancer for Workers Exposed to Antimony Compounds: A Systematic Review

(2019) Anton Saerens et al.   International Journal of Environmental Research and Public Health

Arsenic exposure with reference to neurological impairment: an overview

(2019) Anupama Sharma et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Yeast-based genotoxicity tests for assessing DNA alterations and DNA stress responses: a 40-year overview

(2018) Toshihiko Eki   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimony-Induced Neurobehavioral and Biochemical Perturbations in Mice

(2018) Tanzina Tanu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Epigenetic alteration of mismatch repair genes in the population chronically exposed to arsenic in West Bengal, India

(2018) Pritha Bhattacharjee et al.   ENVIRONMENTAL RESEARCH

Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction

(2018) Matthew Dodson et al.   MOLECULAR AND CELLULAR BIOLOGY

ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules

(2018) Ankit Turakhiya et al.   MOLECULAR CELL

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

Low-level arsenic causes proteotoxic stress and not oxidative stress

(2018) Matthew Dodson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar

(2018) Caroline K. Vilas et al.   TRENDS IN GENETICS

Melarsoprol Resistance in African Trypanosomiasis

(2018) Alan H. Fairlamb et al.   TRENDS IN PARASITOLOGY

ATM directs DNA damage responses and proteostasis via genetically separable pathways

(2018) Ji-Hoon Lee et al.   Science Signaling

Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model

(2018) Sandra Aurora Niño et al.   ACS Chemical Neuroscience

Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1

(2018) Jongmin Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

(2018) Haibo Wang et al.   Nature Communications

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines

(2017) B. Kopp et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Antimony as a global dilemma: Geochemistry, mobility, fate and transport

(2017) Indika Herath et al.   ENVIRONMENTAL POLLUTION

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

(2017) Velmarini Vasquez et al.   JOURNAL OF ALZHEIMERS DISEASE

Cadmium Causes Misfolding and Aggregation of Cytosolic Proteins in Yeast

(2017) Therese Jacobson et al.   MOLECULAR AND CELLULAR BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue

(2017) Xiaofeng Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

(2017) Abdullah R. Chaudhary et al.   TRAFFIC

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

Study of conformational changes and protein aggregation of bovine serum albumin in presence of Sb(III) and Sb(V)

(2017) Marcelo Verdugo et al.   PLoS One

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins

(2016) Do Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular and molecular mechanisms of antimony transport, toxicity and resistance

(2016) Markus J. Tamás   Environmental Chemistry

Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA)

(2016) Benjamin B. Green et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response

(2016) Angel Guerra-Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides

(2016) Juliana Huestis et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration

(2016) Aram B. Cholanians et al.   TOXICOLOGICAL SCIENCES

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite

(2016) Xixi Zhou et al.   Oncotarget

Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction

(2016) Ye Cheng et al.   Oncotarget

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

(2016) Sara Sepe et al.   Cell Reports

Prefoldin Promotes Proteasomal Degradation of Cytosolic Proteins with Missense Mutations by Maintaining Substrate Solubility

(2016) Sophie A. Comyn et al.   PLoS Genetics

Distinct stress conditions result in aggregation of proteins with similar properties

(2016) Alan J. Weids et al.   Scientific Reports

Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts

(2015) Mi-Nam Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Disruption of Mitotic Progression by Arsenic

(2015) J. Christopher States   BIOLOGICAL TRACE ELEMENT RESEARCH

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

Dysregulation of DNA methylation induced by past arsenic treatment causes persistent genomic instability in mammalian cells

(2015) Maurizio Mauro et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Proteomic Analysis Identifies Ribosome Reduction as an Effective Proteotoxic Stress Response

(2015) Angel Guerra-Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Sensitization of Zinc Finger Protein Oxidation by Reactive Oxygen Species through Arsenic Binding

(2015) Xixi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimony bioavailability: Knowledge and research perspectives for sustainable agricultures

(2015) Antoine Pierart et al.   JOURNAL OF HAZARDOUS MATERIALS

Recent advances on antimony(III/V) compounds with potential activity against tumor cells

(2015) S.K. Hadjikakou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease

(2015) Eleonora Carboni et al.   Metallomics

Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8

(2015) Nallani Vijay Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA damage in neurodegenerative diseases

(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease

(2015) Antonella Cardinale et al.   PLoS One

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

(2015) Hai-nan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Transcription errors induce proteotoxic stress and shorten cellular lifespan

(2015) Marc Vermulst et al.   Nature Communications

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Antimony induces oxidative stress and cell death in normal hepatocytes

(2015) Mahmoud Hashemzaei et al.   TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY

Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses

(2014) Michael P. Waalkes et al.   ARCHIVES OF TOXICOLOGY

Multivalency in the Inhibition of Oxidative Protein Folding by Arsenic(III) Species

(2014) Aparna Sapra et al.   BIOCHEMISTRY

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Differential Binding of Monomethylarsonous Acid Compared to Arsenite and Arsenic Trioxide with Zinc Finger Peptides and Proteins

(2014) Xixi Zhou et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arsenic in drinking water and urinary tract cancers: a systematic review of 30 years of epidemiological evidence

(2014) Nathalie Saint-Jacques et al.   Environmental Health

Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair

(2014) Fan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast

(2014) Soheil Rastgou Talemi et al.   MOLECULAR MICROBIOLOGY

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation

(2014) Shiv Shankar et al.   TheScientificWorldJOURNAL

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress

(2014) S. Ibstedt et al.   Biology Open

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Arsenic Binding to Proteins

(2013) Shengwen Shen et al.   CHEMICAL REVIEWS

Coordination of Translational Control and Protein Homeostasis during Severe Heat Stress

(2013) Valeria Cherkasov et al.   CURRENT BIOLOGY

The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem

(2013) Marisa F. Naujokas et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1

(2013) Feng Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

(2013) Adam S. Mastrocola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cuz1/Ynl155w, a Zinc-dependent Ubiquitin-binding Protein, Protects Cells from Metalloid-induced Proteotoxicity

(2013) John Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes

(2013) Botao Liu et al.   MOLECULAR CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

Antimicrobial activity of metals: mechanisms, molecular targets and applications

(2013) Joseph A. Lemire et al.   NATURE REVIEWS MICROBIOLOGY

Chemistry of antimony-based drugs in biological systems and studies of their mechanism of action

(2013) Frédéric Frézard et al.   REVIEWS IN INORGANIC CHEMISTRY

Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair

(2013) Xi Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

(2013) Ireneusz Litwin et al.   PLoS Genetics

Hyperphosphorylation-Induced Tau Oligomers

(2013) Khalid Iqbal et al.   Frontiers in Neurology

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Identification of Catalytic Residues in the As(III) S-Adenosylmethionine Methyltransferase

(2012) Kavitha Marapakala et al.   BIOCHEMISTRY

Arsenic and Antimony Transporters in Eukaryotes

(2012) Ewa Maciaszczyk-Dziubinska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Greater binding affinity of trivalent antimony to a CCCH zinc finger domain compared to a CCHC domain of kinetoplastid proteins

(2012) Frédéric Frézard et al.   Metallomics

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy Is a Cell Self-Protective Mechanism Against Arsenic-Induced Cell Transformation

(2012) Tao Zhang et al.   TOXICOLOGICAL SCIENCES

Microtubules as a Critical Target for Arsenic Toxicity in Lung Cells in Vitro and in Vivo

(2012) Yinzhi Zhao et al.   International Journal of Environmental Research and Public Health

Diverse protective roles of the actin cytoskeleton during oxidative stress

(2011) Michelle E. Farah et al.   Cytoskeleton

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP

(2011) Sergio Zarazúa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs

(2011) Xixi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

Genetic and epigenetic effects of environmental arsenicals

(2011) Toby G. Rossman et al.   Metallomics

Antimony pollution in China

(2011) Mengchang He et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The Arsenic Exposure Hypothesis for Alzheimer Disease

(2010) Gordon Gong et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Aneuploidy as an early mechanistic event in metal carcinogenesis

(2010) Sandra S. Wise et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Antimony Impairs Nucleotide Excision Repair: XPA and XPE as Potential Molecular Targets

(2010) Claudia Grosskopf et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Epigenetic Modifications in Double-Strand Break DNA Damage Signaling and Repair

(2010) D. Rossetto et al.   CLINICAL CANCER RESEARCH

Cancer in experimental animals exposed to arsenic and arsenic compounds

(2010) Erik J. Tokar et al.   CRITICAL REVIEWS IN TOXICOLOGY

Trivalent Arsenic Inhibits the Functions of Chaperonin Complex

(2010) X. Pan et al.   GENETICS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Arsenic for the fool: An exponential connection

(2010) Sergio U. Dani   SCIENCE OF THE TOTAL ENVIRONMENT

Carcinogenic Effects of “Whole-Life” Exposure to Inorganic Arsenic in CD1 Mice

(2010) Erik J. Tokar et al.   TOXICOLOGICAL SCIENCES

Interspecies differences in metabolism of arsenic by cultured primary hepatocytes

(2010) Zuzana Drobná et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antimony Toxicity

(2010) Shyam Sundar et al.   International Journal of Environmental Research and Public Health

Professional exposure to pesticides and Parkinson disease

(2009) Alexis Elbaz et al.   ANNALS OF NEUROLOGY

Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae

(2009) Michael Thorsen et al.   BMC GENOMICS

BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells

(2009) S. Ying et al.   NUCLEIC ACIDS RESEARCH

Antimony in plasma and skin of patients with cutaneous leishmaniasis - relationship with side effects after treatment with meglumine antimoniate

(2009) Diana Brito Da Justa Neves et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Perspectives of antimony compounds in oncology

(2008) Pankaj SHARMA et al.   ACTA PHARMACOLOGICA SINICA

Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

(2008) Detmar Beyersmann et al.   ARCHIVES OF TOXICOLOGY

Heavy metal ions are potent inhibitors of protein folding

(2008) Sandeep K. Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arsenic(III) Species Inhibit Oxidative Protein Foldingin Vitro†

(2008) Danny Ramadan et al.   BIOCHEMISTRY

Urinary Arsenic Speciation and its Correlation with 8-OHdG in Chinese Residents Exposed to Arsenic Through Coal Burning

(2008) Xin Li et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Induction of Cytoplasmic Accumulation of p53: A Mechanism for Low Levels of Arsenic Exposure to Predispose Cells for Malignant Transformation

(2008) Y. Huang et al.   CANCER RESEARCH

Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

(2008) Cynthia Demicheli et al.   CHEMICAL COMMUNICATIONS

Monomethylarsonous Acid Destroys a Tetrathiolate Zinc Finger Much More Efficiently than Inorganic Arsenite: Mechanistic Considerations and Consequences for DNA Repair Inhibition

(2008) Katarzyna Pia̧tek et al.   CHEMICAL RESEARCH IN TOXICOLOGY

KML001 Cytotoxic Activity Is Associated with Its Binding to Telomeric Sequences and Telomere Erosion in Prostate Cancer Cells

(2008) P. Phatak et al.   CLINICAL CANCER RESEARCH

Mitochondrial DNA damage and repair in neurodegenerative disorders

(2008) Jenq-Lin Yang et al.   DNA REPAIR

As(III) inhibits ultraviolet radiation-induced cyclobutane pyrimidine dimer repair via generation of nitric oxide in human keratinocytes

(2008) Wei Ding et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage

(2008) Wei Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic Toxicity to Saccharomyces cerevisiae Is a Consequence of Inhibition of the TORC1 Kinase Combined with a Chronic Stress Response

(2008) Dagmar Hosiner et al.   MOLECULAR BIOLOGY OF THE CELL

Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-κB activation and cell proliferation in human breast cancer MCF-7 cells

(2008) Ruben Ruiz-Ramos et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

(2008) C. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver is a Target of Arsenic Carcinogenesis

(2008) Jie Liu et al.   TOXICOLOGICAL SCIENCES

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity

(2008) Xu-Jun Qin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization

(2008) B. Frazier Taylor et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inorganic Arsenic and Human Prostate Cancer

(2007) Lamia Benbrahim-Tallaa et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity

(2007) Kirk T. Kitchin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY