The increasing complexity of the ubiquitin code

Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover

(2015) D. L. Swaney et al.   EMBO REPORTS

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

(2015) Mingwei Min et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

(2015) Yosua Adi Kristariyanto et al.   MOLECULAR CELL

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

(2015) Martin A. Michel et al.   MOLECULAR CELL

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Cell-fate determination by ubiquitin-dependent regulation of translation

(2015) Achim Werner et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

(2015) Alban Ordureau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate degradation by the proteasome: A single-molecule kinetic analysis

(2015) Y. Lu et al.   SCIENCE

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

(2015) Emma Branigan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains

(2015) Guinevere L. Grice et al.   Cell Reports

RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

(2015) Marco Gatti et al.   Cell Reports

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains

(2014) Ellen M. Valkevich et al.   BIOCHEMISTRY

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

Ubiquitin acetylation inhibits polyubiquitin chain elongation

(2014) F. Ohtake et al.   EMBO REPORTS

Cezanne (OTUD7B) regulates HIF-1  homeostasis in a proteasome-independent manner

(2014) A. Bremm et al.   EMBO REPORTS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Microtubule-Dependent Regulation of Mitotic Protein Degradation

(2014) Ling Song et al.   MOLECULAR CELL

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

(2014) Paul R. Elliott et al.   MOLECULAR CELL

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

(2014) Wei-Chien Yuan et al.   MOLECULAR CELL

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

(2014) Sascha Rutz et al.   NATURE

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

(2014) Juan Liu et al.   NATURE IMMUNOLOGY

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

(2014) Yue Qin et al.   PLoS Pathogens

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification

(2013) Hikaru Tsuchiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation

(2013) Zhao Zhang et al.   DEVELOPMENTAL CELL

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

(2013) Elena Rivkin et al.   NATURE

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

(2013) Danielle L Swaney et al.   NATURE METHODS

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

(2013) Elena Maspero et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Assembly, analysis and architecture of atypical ubiquitin chains

(2013) Manuela K Hospenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational switching of the 26S proteasome enables substrate degradation

(2013) Mary E Matyskiela et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

(2013) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed-Linkage Ubiquitin Chains Send Mixed Messages

(2013) Mark A. Nakasone et al.   STRUCTURE

Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains

(2013) Carlos A. Castañeda et al.   STRUCTURE

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

(2012) Thorkell Gudjonsson et al.   CELL

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells

(2012) Sjoerd J.L. van Wijk et al.   MOLECULAR CELL

The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- or Polyubiquitylation

(2012) Nitzan Shabek et al.   MOLECULAR CELL

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Ubiquitin chain conformation regulates recognition and activity of interacting proteins

(2012) Yu Ye et al.   NATURE

APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1

(2012) Nevena V. Dimova et al.   NATURE CELL BIOLOGY

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Ubiquitin Chain Initiation to Control the Timing of Substrate Degradation

(2011) Adam Williamson et al.   MOLECULAR CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

(2011) Julien D F Licchesi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome

(2010) E. J. Song et al.   GENES & DEVELOPMENT

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Regulated Degradation of Spindle Assembly Factors by the Anaphase-Promoting Complex

(2010) Ling Song et al.   MOLECULAR CELL

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

(2010) Cheol-Sang Hwang et al.   NATURE CELL BIOLOGY

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

(2010) Satpal Virdee et al.   Nature Chemical Biology

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

(2010) Anja Bremm et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

(2010) T. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

(2009) Yasushi Saeki et al.   EMBO JOURNAL

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

(2009) Eric M Cooper et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

The Otubain YOD1 Is a Deubiquitinating Enzyme that Associates with p97 to Facilitate Protein Dislocation from the ER

(2009) Robert Ernst et al.   MOLECULAR CELL

A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β

(2009) Ming Xu et al.   MOLECULAR CELL

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit

(2009) Mathew J. Garnett et al.   NATURE CELL BIOLOGY

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a physiological E2 module for the human anaphase-promoting complex

(2009) A. Williamson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

(2009) Jessica M. Boname et al.   TRAFFIC

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY