Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice

(2016) Degui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

(2016) Andres Binolfi et al.   Nature Communications

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

(2016) Maxime WC Rousseaux et al.   eLife

Therapeutic applications of the TAT-mediated protein transduction system for complex I deficiency and other mitochondrial diseases

(2015) Bo-Yu Lin et al.   Annals of the New York Academy of Sciences

Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box

(2015) Tetsuji Moriyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM28 as a novel transcriptional elongation factor

(2015) Heeyoun Bunch et al.   BMC MOLECULAR BIOLOGY

The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome

(2015) Pavana M. Hegde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

NPDock: a web server for protein–nucleic acid docking

(2015) Irina Tuszynska et al.   NUCLEIC ACIDS RESEARCH

Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil

(2015) Arvind Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson’s Disease

(2014) Anna Oczkowska et al.   CURRENT GENOMICS

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

NEIL2 Protects against Oxidative DNA Damage Induced by Sidestream Smoke in Human Cells

(2014) Altaf H. Sarker et al.   PLoS One

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

(2014) Adrian Flierl et al.   PLoS One

Alpha-Synuclein Function and Dysfunction on Cellular Membranes

(2014) David Snead et al.   Experimental Neurobiology

In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells

(2013) Ulf Dettmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle

(2013) Kai-Li Ma et al.   NEUROPHARMACOLOGY

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

(2013) M. L. Hegde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alternative α-synuclein transcript usage as a convergent mechanism in Parkinson's disease pathology

(2012) Herve Rhinn et al.   Nature Communications

Improved Immunodetection of Endogenous α-Synuclein

(2011) Byung Rho Lee et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of copper(II)-induced misfolding of Parkinson's disease protein

(2011) Frisco Rose et al.   Scientific Reports

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

(2010) S Sengupta et al.   ONCOGENE

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody

(2008) Ling Zhang et al.   BRAIN RESEARCH

Binding of Recombinant but Not Endogenous Prion Protein to DNA Causes DNA Internalization and Expression in Mammalian Cells

(2008) Shaoman Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE