Arsenic-protein interactions as a mechanism of arsenic toxicity

Arsenic: A Global Environmental Challenge

(2021) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

Metallothionein Attenuated Arsenic-Induced Cytotoxicity: The Underlying Mechanism Reflected by Metabolomics and Lipidomics

(2021) Zihe Qi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins

(2021) Xixi Zhou et al.   SEMINARS IN CANCER BIOLOGY

Arsenite impinges on endoplasmic reticulum-mitochondria crosstalk to elicit mitochondrial ROS formation and downstream toxicity

(2021) Orazio Cantoni et al.   SEMINARS IN CANCER BIOLOGY

Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A State-of-the-Science Review of Arsenic’s Effects on Glucose Homeostasis in Experimental Models

(2020) Felicia Castriota et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Role of Reactive Oxygen Species in Arsenic Toxicity

(2020) Yuxin Hu et al.   Biomolecules

Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arsenite Exposure Displaces Zinc from ZRANB2 Leading to Altered Splicing

(2020) Mayukh Banerjee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arsenite suppresses the transcriptional activity of EVI1 through the binding to CCHC-type Zn finger domain

(2020) Masatoshi Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer

(2020) Jeanne M. Danes et al.   FASEB JOURNAL

Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer

(2020) Lu Gao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site

(2020) Shuo Chen et al.   CANCER CELL

Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation

(2020) Nandita Medda et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations

(2020) Cassandra J. Meakin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metals and Mechanisms of Carcinogenesis

(2019) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

Pathways of arsenic uptake and efflux

(2019) Luis D. Garbinski et al.   ENVIRONMENT INTERNATIONAL

Arsenic impairs GLUT1 trafficking through the inhibition of the calpain system in lymphocytes

(2019) Pablo Pánico et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2

(2018) Ji Jiang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metal binding properties, stability and reactivity of zinc fingers

(2018) Katarzyna Kluska et al.   COORDINATION CHEMISTRY REVIEWS

Environmental arsenic exposure: From genetic susceptibility to pathogenesis

(2018) Brenda C. Minatel et al.   ENVIRONMENT INTERNATIONAL

Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug

(2018) Cao Kaiming et al.   Metallomics

Effects of arsenic toxicity beyond epigenetic modifications

(2017) Geir Bjørklund et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Low-level arsenic exposure from drinking water is associated with prostate cancer in Iowa

(2017) Taehyun Roh et al.   ENVIRONMENTAL RESEARCH

Arsenic exposures alter clinical indicators of anemia in a male population of smokers and non-smokers in Bangladesh

(2017) Faruque Parvez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic and chromium topsoil levels and cancer mortality in Spain

(2016) Olivier Núñez et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Metabolism and toxicity of arsenicals in mammals

(2016) Adeel Sattar et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine

(2015) Shuo Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Identification of Arsenic Direct-Binding Proteins in Acute Promyelocytic Leukaemia Cells

(2015) Tao Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Selective Sensitization of Zinc Finger Protein Oxidation by Reactive Oxygen Species through Arsenic Binding

(2015) Xixi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

(2015) Hai-nan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arsenic-mediated nephrotoxicity

(2015) Ma Ludivina Robles-Osorio et al.   RENAL FAILURE

Alteration of mammary gland development and gene expression by in utero exposure to arsenic

(2015) Daniela A. Parodi et al.   REPRODUCTIVE TOXICOLOGY

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

(2015) Qian Qian Wang et al.   Oncotarget

The mechanistic basis of arsenicosis: Pathogenesis of skin cancer

(2014) Katherine M. Hunt et al.   CANCER LETTERS

Differential Binding of Monomethylarsonous Acid Compared to Arsenite and Arsenic Trioxide with Zinc Finger Peptides and Proteins

(2014) Xixi Zhou et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Reaction of Arsenite with Proteins Relies on Solution Conditions

(2014) Linhong Zhao et al.   INORGANIC CHEMISTRY

Arsenite Binds to the RING Finger Domains of RNF20-RNF40 Histone E3 Ubiquitin Ligase and Inhibits DNA Double-Strand Break Repair

(2014) Fan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Developmental Neurotoxicity of Arsenic: Cognitive and Behavioral Consequences of Early Life Exposure

(2014) Molly Tolins et al.   Annals of Global Health

Arsenic Exposure and Cancer Mortality in a US-Based Prospective Cohort: The Strong Heart Study

(2013) E. Garcia-Esquinas et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Arsenic Binding to Proteins

(2013) Shengwen Shen et al.   CHEMICAL REVIEWS

Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non-cytotoxic cellular concentrations

(2013) Julie A. Gosse et al.   JOURNAL OF APPLIED TOXICOLOGY

Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair

(2013) Xi Sun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selectivity of arsenite interaction with zinc finger proteins

(2012) Linhong Zhao et al.   Metallomics

Arsenic Induces Functional Re-Expression of Estrogen Receptor α by Demethylation of DNA in Estrogen Receptor-Negative Human Breast Cancer

(2012) Juan Du et al.   PLoS One

Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs

(2011) Xixi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of arsenate and arsenite on signal transduction pathways: an update

(2010) Ingrid L. Druwe et al.   ARCHIVES OF TOXICOLOGY

Arsenic abrogates the estrogen-signaling pathway in the rat uterus

(2010) Aniruddha Chatterjee et al.   Reproductive Biology and Endocrinology

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage

(2008) Wei Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic as an Endocrine Disruptor: Arsenic Disrupts Retinoic Acid Receptor–and Thyroid Hormone Receptor–Mediated Gene Regulation and Thyroid Hormone–Mediated Amphibian Tail Metamorphosis

(2007) Jennifer C. Davey et al.   ENVIRONMENTAL HEALTH PERSPECTIVES