Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription
Authors
Keywords
-
Journal
eLife
Volume 8, Issue -, Pages -
Publisher
eLife Sciences Publications, Ltd
Online
2019-04-17
DOI
10.7554/elife.42988
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
- (2017) Ryan G Lim et al. NATURE NEUROSCIENCE
- Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons
- (2016) Vsevolod Telezhkin et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases
- (2016) Conceição Bettencourt et al. ANNALS OF NEUROLOGY
- Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes
- (2016) Anirban Chakraborty et al. Nature Communications
- Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies
- (2016) Maria Jimenez-Sanchez et al. Cold Spring Harbor Perspectives in Medicine
- Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease
- (2015) Jong-Min Lee et al. CELL
- Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
- (2015) Ram Madabhushi et al. CELL
- Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation
- (2015) Anirban Chakraborty et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3
- (2015) Rui Gao et al. PLoS Genetics
- The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
- (2015) Arpita Chatterjee et al. PLoS Genetics
- Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis
- (2014) Amit Kumar et al. DRUG DISCOVERY TODAY
- Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective
- (2014) Luis M. Valor MOLECULAR NEUROBIOLOGY
- DNA Damage and Its Links to Neurodegeneration
- (2014) Ram Madabhushi et al. NEURON
- Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease
- (2014) X.-H. Lu et al. Science Translational Medicine
- Mitochondrial DNA damage Is associated with reduced mitochondrial bioenergetics in Huntington's disease
- (2012) Almas Siddiqui et al. FREE RADICAL BIOLOGY AND MEDICINE
- Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations
- (2012) Cathryn Poulton et al. NEUROGENETICS
- Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175
- (2012) Liliana B. Menalled et al. PLoS One
- Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity
- (2011) A. Giralt et al. HUMAN MOLECULAR GENETICS
- Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage
- (2011) U. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome
- (2011) Santi M. Mandal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain
- (2011) Yukio Takeshita et al. NEUROREPORT
- Early and Late Events Induced by PolyQ-expanded Proteins
- (2010) Alessandra Bertoni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Huntington's disease: from molecular pathogenesis to clinical treatment
- (2010) Christopher A Ross et al. LANCET NEUROLOGY
- Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
- (2010) Jun Shen et al. NATURE GENETICS
- N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
- (2008) A. L. Orr et al. JOURNAL OF NEUROSCIENCE
- DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates
- (2008) Jennifer Illuzzi et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Transcription-coupled DNA repair: two decades of progress and surprises
- (2008) Philip C. Hanawalt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started