Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection

(2018) Juan Zhao et al.   Cell Discovery

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

(2018) Lam Nhat Nguyen et al.   Cell Death & Disease

Premature aging and immune senescence in HIV-infected children

(2016) Ketty Gianesin et al.   AIDS

Modeling HIV-1 Latency in Primary T Cells Using a Replication-Competent Virus

(2016) Laura J. Martins et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Telomeres in aging and disease: lessons from zebrafish

(2016) Madalena C. Carneiro et al.   Disease Models & Mechanisms

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(2016) Viviana Cobos Jiménez et al.   JOURNAL OF INFECTIOUS DISEASES

Protection of CD4 + T cells from hepatitis C virus infection-associated senescence via ΔNp63–miR-181a–Sirt1 pathway

(2016) Yun Zhou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA

(2016) Andrew M. Gross et al.   MOLECULAR CELL

Immunodetection of human topoisomerase I-DNA covalent complexes

(2016) Anand G. Patel et al.   NUCLEIC ACIDS RESEARCH

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

(2016) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

HCV monoinfection and HIV/HCV coinfection enhance T-cell immune senescence in injecting drug users early during infection

(2016) Bart P. X. Grady et al.   Immunity & Ageing

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Hepatitis C virus-induced reduction in miR-181a impairs CD4+T-cell responses through overexpression of DUSP6

(2015) Guang Y. Li et al.   HEPATOLOGY

Cell death during crisis is mediated by mitotic telomere deprotection

(2015) Makoto T. Hayashi et al.   NATURE

Association Between Short Leukocyte Telomere Length and HIV Infection in a Cohort Study: No Evidence of a Relationship With Antiretroviral Therapy

(2014) DeAnna L. Zanet et al.   CLINICAL INFECTIOUS DISEASES

Immune Exhaustion and Immune Senescence: Two Distinct Pathways for HBV Vaccine Failure During HCV and/or HIV Infection

(2013) Zhi Q. Yao et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Understanding telomere diseases through analysis of patient-derived iPS cells

(2013) Luis FZ Batista et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

KLRG1 Impairs CD4+ T Cell Responses via p16ink4a and p27kip1 Pathways: Role in Hepatitis B Vaccine Failure in Individuals with Hepatitis C Virus Infection

(2013) L. Shi et al.   JOURNAL OF IMMUNOLOGY

The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response

(2013) Anthony J. Cesare et al.   MOLECULAR CELL

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

One Identity or More for Telomeres?

(2013) Marie-Josèphe Giraud-Panis et al.   Frontiers in Oncology

Expression ofp16INK4aas a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

(2012) Julie A. E. Nelson et al.   AGING CELL

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

HIV Infection-Related Premature Immunosenescence: High Rates of Immune Exhaustion After Short Time of Infection

(2011) Sara Ferrando-Martinez et al.   CURRENT HIV RESEARCH

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection

(2010) Matthew Hoare et al.   JOURNAL OF HEPATOLOGY

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

(2010) Kaori Fujita et al.   NATURE CELL BIOLOGY

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

(2009) W Brian Dalton et al.   Future Oncology

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KML001 Cytotoxic Activity Is Associated with Its Binding to Telomeric Sequences and Telomere Erosion in Prostate Cancer Cells

(2008) P. Phatak et al.   CLINICAL CANCER RESEARCH