Molecular Link between DNA Damage Response and Microtubule Dynamics

Small Prokaryotic DNA-Binding Proteins Protect Genome Integrity throughout the Life Cycle

(2022) Katja Molan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair

(2021) Shuyun Ma et al.   JOURNAL OF CELL BIOLOGY

Regulation of Nuclear Mechanics and the Impact on DNA Damage

(2021) Ália dos Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delta and epsilon tubulin in mammalian development

(2021) G. Gemma Stathatos et al.   TRENDS IN CELL BIOLOGY

Interphase microtubules in nuclear organization and genome maintenance

(2021) Mitra Shokrollahi et al.   TRENDS IN CELL BIOLOGY

The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

(2021) Janna Luessing et al.   Cell Reports

DNA Damage Protection for Enhanced Bacterial Survival Under Simulated Low Earth Orbit Environmental Conditions in Escherichia coli

(2021) Jaume Puig et al.   Frontiers in Microbiology

Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

(2020) Songli Zhu et al.   eLife

Nucleoid Associated Proteins: The Small Organizers That Help to Cope With Stress

(2020) Joanna Hołówka et al.   Frontiers in Microbiology

The role of α tubulin acetyltransferase αTAT1 in DNA damage response

(2020) Na Mi Ryu et al.   JOURNAL OF CELL SCIENCE

DNA damage alters nuclear mechanics through chromatin reorganization

(2020) Ália dos Santos et al.   NUCLEIC ACIDS RESEARCH

HDAC6 regulates DNA damage response via deacetylating MLH1

(2019) Mu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centrobin plays a role in the cellular response to DNA damage

(2019) Na Mi Ryu et al.   CELL CYCLE

Regulation of cell division in bacteria by monitoring genome integrity and DNA replication status

(2019) Peter E. Burby et al.   JOURNAL OF BACTERIOLOGY

The response to DNA damage in heterochromatin domains

(2018) Anna Fortuny et al.   CHROMOSOMA

Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?

(2018) Manuel Haschka et al.   EMBO REPORTS

Recent advances in microtubule-stabilizing agents

(2018) Ya-Nan Cao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

(2018) Michel O. Steinmetz et al.   TRENDS IN CELL BIOLOGY

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer

(2018) Luis Paz-Ares et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chromatin and nucleosome dynamics in DNA damage and repair

(2017) Michael H. Hauer et al.   GENES & DEVELOPMENT

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage

(2017) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nuclear Dynamics of Heterochromatin Repair

(2017) Nuno Amaral et al.   TRENDS IN GENETICS

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Is inflammatory micronucleation the key to a successful anti-mitotic cancer drug?

(2017) T. J. Mitchison et al.   Open Biology

The Emerging Role of the Cytoskeleton in Chromosome Dynamics

(2017) Maya Spichal et al.   Frontiers in Genetics

Mechanisms of Mitotic Spindle Assembly

(2016) Sabine Petry   Annual Review of Biochemistry

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

(2016) Aniek Janssen et al.   GENES & DEVELOPMENT

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining

(2016) Katherine S. Lawrence et al.   JOURNAL OF CELL BIOLOGY

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

(2016) Hui Zhang et al.   Cell Reports

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

The microtubule nucleation activity of centrobin in both the centrosome and cytoplasm

(2015) Wonjung Shin et al.   CELL CYCLE

Shaping of interphase chromosomes by the microtubule network

(2015) Yael Maizels et al.   FEBS Journal

The DNA-Binding Protein from Starved Cells (Dps) Utilizes Dual Functions To Defend Cells against Multiple Stresses

(2015) Vlad O. Karas et al.   JOURNAL OF BACTERIOLOGY

Accessorizing and anchoring the LINC complex for multifunctionality

(2015) Wakam Chang et al.   JOURNAL OF CELL BIOLOGY

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness

(2015) Takashi Furusawa et al.   Nature Communications

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Sequential binding of FurA from Anabaena sp. PCC 7120 to iron boxes: Exploring regulation at the nanoscale

(2014) María Carmen Pallarés et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Post-translational modifications of tubulin

(2014) Maria M. Magiera et al.   CURRENT BIOLOGY

A Genomic Multiprocess Survey of Machineries that Control and Link Cell Shape, Microtubule Organization, and Cell-Cycle Progression

(2014) Veronika Graml et al.   DEVELOPMENTAL CELL

NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin

(2013) Joonhyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

(2013) Andrea Rothballer et al.   CHROMOSOMA

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

(2013) Laurence Zitvogel et al.   IMMUNITY

DNA Protection by the Bacterial Ferritin Dps via DNA Charge Transport

(2013) Anna R. Arnold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cep63 and Cep152 Cooperate to Ensure Centriole Duplication

(2013) Nicola J. Brown et al.   PLoS One

Shedding light on nuclear actin dynamics and function

(2013) Richard Treisman   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms of nuclear actin in chromatin-remodeling complexes

(2013) Prabodh Kapoor et al.   TRENDS IN CELL BIOLOGY

Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

(2013) Guillaume Chouinard et al.   Cell Division

αTAT1 is the major α-tubulin acetyltransferase in mice

(2013) Nereo Kalebic et al.   Nature Communications

New Mitotic Regulators Released from Chromatin

(2013) Hideki Yokoyama et al.   Frontiers in Oncology

Microtubule dynamics alter the interphase nucleus

(2012) Gabi Gerlitz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway

(2012) Mi-Ri Gwon et al.   FEBS LETTERS

Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination

(2012) F. R. Neumann et al.   GENES & DEVELOPMENT

Cell cycle regulation by the NEK family of protein kinases

(2012) A. M. Fry et al.   JOURNAL OF CELL SCIENCE

DNA Repair and Genome Maintenance in Bacillus subtilis

(2012) J. S. Lenhart et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search

(2012) Anthony L. Forget et al.   NATURE

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Chromatin maintenance by a molecular motor protein

(2012) Manjari Mazumdar et al.   Nucleus

The human Ino80 binds to microtubule via the E-hook of tubulin: Implications for the role in spindle assembly

(2011) Eun-Jung Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity

(2011) Manolis Papamichos-Chronakis et al.   CELL

A novel role of the chromokinesin Kif4A in DNA damage response

(2011) Guikai Wu et al.   CELL CYCLE

Nuclear localization of γ-tubulin affects E2F transcriptional activity and S-phase progression

(2011) Greta Höög et al.   FASEB JOURNAL

Centrobin–tubulin interaction is required for centriole elongation and stability

(2011) Radhika Gudi et al.   JOURNAL OF CELL BIOLOGY

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule nucleation by γ-tubulin complexes

(2011) Justin M. Kollman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

Nek family of kinases in cell cycle, checkpoint control and cancer

(2011) Larissa Moniz et al.   Cell Division

The nuclear envelope as a chromatin organizer

(2011) Nikolaj Zuleger et al.   Nucleus

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B

(2010) Young Mi Lee et al.   GENE

Centrobin/NIP2 Is a Microtubule Stabilizer Whose Activity Is Enhanced by PLK1 Phosphorylation during Mitosis

(2010) Jungmin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

MEC-17 is an α-tubulin acetyltransferase

(2010) Jyothi S. Akella et al.   NATURE

CEP152 is a genome maintenance protein disrupted in Seckel syndrome

(2010) Ersan Kalay et al.   NATURE GENETICS

Bacterial nucleoid-associated proteins, nucleoid structure and gene expression

(2010) Shane C. Dillon et al.   NATURE REVIEWS MICROBIOLOGY

Centrobin regulates the assembly of functional mitotic spindles

(2010) J M Jeffery et al.   ONCOGENE

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

ISWI is a RanGTP-dependent MAP required for chromosome segregation

(2009) Hideki Yokoyama et al.   JOURNAL OF CELL BIOLOGY

Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

(2009) Alexandra Tibelius et al.   JOURNAL OF CELL BIOLOGY

Pericentrin in cellular function and disease

(2009) Benedicte Delaval et al.   JOURNAL OF CELL BIOLOGY

Emerging Connection Between Centrosome and DNA Repair Machinery

(2009) Mikio SHIMADA et al.   JOURNAL OF RADIATION RESEARCH

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

(2009) Eloise Smith et al.   NATURE CELL BIOLOGY

Recombinational DNA repair in a cellular context: a search for the homology search

(2009) Allon Weiner et al.   NATURE REVIEWS MICROBIOLOGY

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The bacterial LexA transcriptional repressor

(2008) M. Butala et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SSB as an Organizer/Mobilizer of Genome Maintenance Complexes

(2008) Robert D. Shereda et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Chromatin remodelling and actin organisation

(2008) Ann-Kristin Östlund Farrants   FEBS LETTERS

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1

(2008) S. Sivasubramaniam et al.   GENES & DEVELOPMENT

 Tub23C Interacts Genetically With Brahma Chromatin-Remodeling Complexes in Drosophila melanogaster

(2008) M. Vazquez et al.   GENETICS

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

(2008) Nadya Dimitrova et al.   NATURE

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY

Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species

(2008) K. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the Pericentrin (PCNT) Gene Cause Primordial Dwarfism

(2008) A. Rauch et al.   SCIENCE