Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling

Arsenic intoxication: general aspects and chelating agents

(2020) Geir Bjørklund et al.   ARCHIVES OF TOXICOLOGY

Assessing potential mechanisms of arsenic-induced skin lesions and cancers: Human and in vitro evidence

(2020) Qibing Zeng et al.   ENVIRONMENTAL POLLUTION

Exposure to arsenite and cadmium induces organotoxicity and miRNAs deregulation in male rats

(2020) Farah Mumtaz et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Arsenic in a groundwater environment in Bangladesh: Occurrence and mobilization

(2020) Md. Enamul Huq et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Transplacental arsenic exposure produced 5-methylcytosine methylation changes and aberrant microRNA expressions in livers of male fetal mice

(2020) Jie Liu et al.   TOXICOLOGY

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells

(2020) Chen Liang et al.   JOURNAL OF HAZARDOUS MATERIALS

PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling

(2020) Tianxiao Duan et al.   TOXICOLOGY IN VITRO

Arsenic speciation and biotransformation pathways in the aquatic ecosystem: The significance of algae

(2020) Muhammad Mahroz Hussain et al.   JOURNAL OF HAZARDOUS MATERIALS

Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor

(2019) Cristian Soza-Ried et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

MicroRNAs play an important role in contributing to arsenic susceptibility in the chronically exposed individuals of West Bengal, India

(2019) Nilanjana Banerjee et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Arsenic exposure: A public health problem leading to several cancers

(2019) I. Palma-Lara et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Promoting the productivity and quality of brinjal aligned with heavy metals immobilization in a wastewater irrigated heavy metal polluted soil with biochar and chitosan

(2018) Veysel Turan et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Environmental arsenic exposure: From genetic susceptibility to pathogenesis

(2018) Brenda C. Minatel et al.   ENVIRONMENT INTERNATIONAL

Speciation, mobilization, and bioaccessibility of arsenic in geogenic soil profile from Hong Kong

(2018) Jin-li Cui et al.   ENVIRONMENTAL POLLUTION

PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis

(2018) Qiao Yi Chen et al.   MOLECULAR PHARMACOLOGY

Physiographical variability in arsenic dynamics in Bangladeshi soils

(2018) M. Tanvir A. Chowdhury et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Impact of prenatal arsenic exposure on chronic adult diseases

(2018) Jamie L. Young et al.   Systems Biology in Reproductive Medicine

New toxic emerging contaminants: beyond the toxicological effects

(2018) Carlos Lodeiro et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Thiolation in arsenic metabolism: a chemical perspective

(2018) Changjun Fan et al.   Metallomics

miRNA expression profiles of premalignant and malignant arsenic-induced skin lesions

(2018) Laila Al-Eryani et al.   PLoS One

A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes

(2018) Qing Zhou et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Arsenic and Fasting Blood Glucose in the Context of Other Drinking Water Chemicals: A Cross-Sectional Study in Bangladesh

(2018) Shadassa Ourshalimian et al.   ENVIRONMENTAL RESEARCH

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

(2018) Paul B. Tchounwou et al.   ENVIRONMENTAL TOXICOLOGY

Arsenic immobilization through regulated ferrolysis in paddy field amendment with bismuth impregnated biochar

(2018) Ningyuan Zhu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Effects of arsenic toxicity beyond epigenetic modifications

(2017) Geir Bjørklund et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Chronic arsenic exposure and risk of carotid artery disease: The Strong Heart Study

(2017) Farrah J. Mateen et al.   ENVIRONMENTAL RESEARCH

Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors

(2017) Priyanka Prasad et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma

(2017) Gangyang Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Unusual Case of Acute Psychosis With Obsessive-Compulsive Features Following Arsenic Poisoning

(2017) HANJING E. WU et al.   Journal of Psychiatric Practice

Molecular insight of arsenic-induced carcinogenesis and its prevention

(2017) Paramita Mandal   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The association between socioeconomic status and subclinical atherosclerosis in a rural Bangladesh population

(2017) Michael Garshick et al.   PREVENTIVE MEDICINE

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo

(2017) Chinthalapally V. Rao et al.   Oncotarget

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

A Review of the Effects of Chronic Arsenic Exposure on Adverse Pregnancy Outcomes

(2017) Abul Milton et al.   International Journal of Environmental Research and Public Health

Circulating miRNAs and their target genes associated with arsenism caused by coal-burning

(2017) Baofei Sun et al.   Toxicology Research

Alleviation of nickel toxicity and an improvement in zinc bioavailability in sunflower seed with chitosan and biochar application in pH adjusted nickel contaminated soil

(2017) Veysel Turan et al.   Archives of Agronomy and Soil Science

Immunomodulatory Role of Arsenic in Regulatory T Cells

(2017) Rizwanul Haque et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review

(2016) Tiffany R. Sanchez et al.   ENVIRONMENTAL RESEARCH

Arsenic contamination of groundwater and its induced health effects in Shahpur block, Bhojpur district, Bihar state, India: risk evaluation

(2016) Dipankar Chakraborti et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing

(2016) Birget Moe et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Thiolated arsenicals in arsenic metabolism: Occurrence, formation, and biological implications

(2016) Yuzhen Sun et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Inorganic arsenic: A non-genotoxic carcinogen

(2016) Samuel M. Cohen et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway

(2016) Yuya Yamaguchi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The effects of sulfur, cattle, and poultry manure addition on soil phosphorus

(2016) Osman SÖNMEZ et al.   Turkish Journal of Agriculture and Forestry

An empirical analysis of land property lawsuits and rainfalls

(2016) Li-Chen Chou et al.   SpringerPlus

Protective Effects of Zinc Against Acute Arsenic Toxicity by Regulating Antioxidant Defense System and Cumulative Metallothionein Expression

(2015) Renuka Ganger et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Subcellular distribution, modulation of antioxidant and stress-related genes response to arsenic in Brassica napus L.

(2015) Muhammad A. Farooq et al.   ECOTOXICOLOGY

Arsenic and human health effects: A review

(2015) Khaja Shameem Mohammed Abdul et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic low level arsenic exposure evokes inflammatory responses and DNA damage

(2015) Kaustav Dutta et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress

(2015) Xuefeng Ren et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic

(2015) Zhuang Miao et al.   Oncotarget

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

Increased Lung and Bladder Cancer Incidence in Adults after In Utero and Early-Life Arsenic Exposure

(2014) C. Steinmaus et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Arsenic Induced Overexpression of Inflammatory Cytokines Based on the Human Urothelial Cell Model in Vitro and Urinary Secretion of Individuals Chronically Exposed to Arsenic

(2014) Shengnan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Arsenic and selenium toxicity and their interactive effects in humans

(2014) Hong-Jie Sun et al.   ENVIRONMENT INTERNATIONAL

Oxidative stress, glutathione level and antioxidant response to heavy metals in multi-resistant pathogen, Candida tropicalis

(2014) Sidra Ilyas et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Computer-Aided Targeting of the PI3K/Akt/mTOR Pathway: Toxicity Reduction and Therapeutic Opportunities

(2014) Tan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of urinary speciated arsenic in NHANES: Issues in interpretation in the context of potential inorganic arsenic exposure

(2014) Lesa L. Aylward et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Arsenic and Lung Cancer in Never-Smokers: Lessons from Chile

(2013) Victor D. Martinez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Arsenic trioxide induces unfolded protein response in vascular endothelial cells

(2013) Ching-Yi Weng et al.   ARCHIVES OF TOXICOLOGY

Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic

(2013) Erik J. Tokar et al.   ARCHIVES OF TOXICOLOGY

Drinking Water Arsenic in Northern Chile: High Cancer Risks 40 Years after Exposure Cessation

(2013) C. M. Steinmaus et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Oxidative stress indicators and trace element concentrations in tissues of mako shark (Isurus oxyrinchus)

(2013) Marcela Vélez-Alavez et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Roles of EGFR, PI3K, AKT, and mTOR in Heavy Metal-Induced Cancer

(2013) Richard L. Carpenter et al.   CURRENT CANCER DRUG TARGETS

Genotoxic effect of exposure to metal(loid)s. A molecular epidemiology survey of populations living and working in Panasqueira mine area, Portugal

(2013) Patrícia Coelho et al.   ENVIRONMENT INTERNATIONAL

Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: An implication for the paradoxical mechanism

(2013) Xuejun Jiang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles

(2013) Udomratana Vattanasit et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Trichosanthes dioica Root Alleviates Arsenic Induced Myocardial Toxicity in Rats

(2013) Sanjib Bhattacharya et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Arsenic-induced promoter hypomethylation and over-expression of ERCC2 reduces DNA repair capacity in humans by non-disjunction of the ERCC2–Cdk7 complex

(2013) Somnath Paul et al.   Metallomics

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular features in arsenic-induced lung tumors

(2013) Roland Hubaux et al.   Molecular Cancer

Arsenic Induces VL30 Retrotransposition: The Involvement of Oxidative Stress and Heat-Shock Protein 70

(2013) Georgios Markopoulos et al.   TOXICOLOGICAL SCIENCES

Cytotoxicity and gene expression changes induced by inorganic and organic trivalent arsenicals in human cells

(2013) Puttappa R. Dodmane et al.   TOXICOLOGY

Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption

(2013) Ritesh K. Srivastava et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Characterization of arsenic-induced cytotoxicity in liver with stress in erythrocytes and its reversibility with Pleurotus florida lectin

(2013) Tanmoy Rana et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

(2013) Ireneusz Litwin et al.   PLoS Genetics

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Nrf2-mediated redox signaling in arsenic carcinogenesis: a review

(2012) Dona Sinha et al.   ARCHIVES OF TOXICOLOGY

Metabolism of arsenic and its toxicological relevance

(2012) Takayuki Watanabe et al.   ARCHIVES OF TOXICOLOGY

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons and DNA Damage in Taiwanese Traffic Conductors

(2012) H.-B. Huang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Oxidative stress and arsenic toxicity: Role of NADPH oxidases

(2012) D.K. Gupta et al.   CHEMOSPHERE

Evaluation of gene expression changes in human primary uroepithelial cells following 24-Hr exposures to inorganic arsenic and its methylated metabolites

(2012) Janice W. Yager et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation

(2012) Min Ling et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic-Mediated Activation of the Nrf2-Keap1 Antioxidant Pathway

(2012) Alexandria Lau et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Antagonistic Role of Tea Against Sodium Arsenite-Induced Oxidative DNA Damage and Inhibition of DNA Repair in Swiss Albino Mice

(2012) Dona Sinha et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype

(2012) Mohammad Bakhtiar Hossain et al.   Metallomics

Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis

(2012) J. Christopher States et al.   PLoS One

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased serum level of epidermal growth factor receptor in liver cancer patients and its association with exposure to arsenic

(2012) Tzu-I Sung et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells

(2012) Todd A. Stueckle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh

(2012) Brandon L. Pierce et al.   PLoS Genetics

Akt Activation Is Responsible for Enhanced Migratory and Invasive Behavior of Arsenic-Transformed Human Bronchial Epithelial Cells

(2011) Zhishan Wang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic Exposure and Toxicology: A Historical Perspective

(2011) Michael F. Hughes et al.   TOXICOLOGICAL SCIENCES

Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: The potential involvement of p21 expression and p53 phosphorylation

(2011) Yoon-Jae Kim et al.   TOXICOLOGY

Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells

(2011) Shawn M. Wnek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic trioxide induces the apoptosis of human breast cancer MCF-7 cells through activation of caspase-3 and inhibition of HERG channels

(2011) YING WANG et al.   Experimental and Therapeutic Medicine

Health Effects of Early Life Exposure to Arsenic

(2010) Marie Vahter   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Antioxidant and metabolic impairment result in DNA damage in arsenic-exposed individuals with severe dermatological manifestations in Eastern India

(2010) Smarajit Maiti et al.   ENVIRONMENTAL TOXICOLOGY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study

(2010) Maria Argos et al.   LANCET

Human arsenic exposure and risk assessment at the landscape level: a review

(2009) Nasreen Islam Khan et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells

(2009) E. Dopp et al.   ENVIRONMENTAL RESEARCH

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis

(2009) Yang Sun et al.   TOXICOLOGY

Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure

(2009) William Jaime Jo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid

(2008) Prasenjit Manna et al.   ARCHIVES OF TOXICOLOGY

Epigenetic remodeling during arsenical-induced malignant transformation

(2008) Taylor J. Jensen et al.   CARCINOGENESIS

Arsenite alters global histone H3 methylation

(2008) X. Zhou et al.   CARCINOGENESIS

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Arsenic in groundwater: A threat to sustainable agriculture in South and South-east Asia

(2008) Hugh Brammer et al.   ENVIRONMENT INTERNATIONAL

Inhibition by methylated organoarsenicals of the respiratory 2-oxo-acid dehydrogenases

(2008) Erik R. Bergquist et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction

(2008) Xiao-Jun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY