The Role of Reactive Oxygen Species in Arsenic Toxicity

Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers

(2020) Suman Mukhopadhyay et al.   CANCER RESEARCH

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Proanthocyanidins Antagonize Arsenic-Induced Oxidative Damage and Promote Arsenic Methylation through Activation of the Nrf2 Signaling Pathway

(2019) Mengchuan Xu et al.   Oxidative Medicine and Cellular Longevity

Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic

(2019) Zhiyuan Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats

(2019) Shanmugam Thangapandiyan et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The Simpler the Better: Oral Arsenic for Acute Promyelocytic Leukemia

(2019) Hong-Hu Zhu et al.   BLOOD

Daphnetin activates the Nrf2-dependent antioxidant response to prevent arsenic-induced oxidative insult in human lung epithelial cells

(2019) Xiaohong Lv et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis

(2019) Sushweta Mahalanobish et al.   FOOD AND CHEMICAL TOXICOLOGY

Pterostilbene Activates the Nrf2-Dependent Antioxidant Response to Ameliorate Arsenic-Induced Intracellular Damage and Apoptosis in Human Keratinocytes

(2019) Junfeng Zhou et al.   Frontiers in Pharmacology

The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62

(2019) Daqian Xu et al.   Science Advances

Arsenite and its trivalent methylated metabolites inhibit glucose-stimulated calcium influx and insulin secretion in murine pancreatic islets

(2019) Madelyn Huang et al.   ARCHIVES OF TOXICOLOGY

Metabolic Regulation of Redox Balance in Cancer

(2019) Vinee Purohit et al.   Cancers

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

(2019) Lidija Milkovic et al.   Cells

Oral arsenic trioxide ORH-2014 pharmacokinetic and safety profile in patients with advanced hematologic disorders

(2019) Farhad Ravandi et al.   HAEMATOLOGICA

Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury

(2019) Meiyu Han et al.   Drug Design Development and Therapy

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM2.5)

(2019) Pengyuan Dai et al.   CHEMOSPHERE

The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation

(2019) Hongjing Zhao et al.   ENVIRONMENTAL POLLUTION

Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes

(2019) Xiafang Wu et al.   Oxidative Medicine and Cellular Longevity

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2

(2018) Ji Jiang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ameliorative effects of selenium on arsenic-induced cytotoxicity in PC12 cells via modulating autophagy/apoptosis

(2018) Md. Mostafizur Rahman et al.   CHEMOSPHERE

Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water

(2018) Xiaoyan Du et al.   ENVIRONMENTAL POLLUTION

Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades

(2018) Sukanya Saha et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Organic Arsenicals as Functional Motifs in Polymer and Biomaterials Science

(2018) Joji Tanaka et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and Apoptotic Cell Death Pathway

(2018) Sonjit Das et al.   Oxidative Medicine and Cellular Longevity

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

The development of a pregnancy PBPK Model for Bisphenol A and its evaluation with the available biomonitoring data

(2018) Raju Prasad Sharma et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Low-level arsenic causes proteotoxic stress and not oxidative stress

(2018) Matthew Dodson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bringing in vitro analysis closer to in vivo : Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

(2018) Marcha Verheijen et al.   TOXICOLOGY LETTERS

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors

(2018) Radhakrishnan Chandraprabha Vineetha et al.   TOXICOLOGY MECHANISMS AND METHODS

L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors

(2018) Radhakrishnan Chandraprabha Vineetha et al.   TOXICOLOGY MECHANISMS AND METHODS

Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism

(2018) Anusha Angajala et al.   Frontiers in Immunology

A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes

(2018) Qing Zhou et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Redox manipulation of the manganese metal in human manganese superoxide dismutase for neutron diffraction

(2018) Jahaun Azadmanesh et al.   Acta Crystallographica Section F-Structural Biology Communications

In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds

(2018) Eric Fabian et al.   ARCHIVES OF TOXICOLOGY

Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells

(2018) Qiaoting Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dysregulation of Sqstm1, mitophagy, and apoptotic genes in chronic exposure to arsenic and high-fat diet (HFD)

(2018) Marzieh Zeinvand-Lorestani et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3

(2018) Jingru Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway

(2018) Lingzhi Zhong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ameliorative effect of gallic acid on sodium arsenite-induced spleno-, cardio- and hemato-toxicity in rats

(2018) Azam Hosseinzadeh et al.   LIFE SCIENCES

Arsenic trioxide and/or copper sulfate induced apoptosis and autophagy associated with oxidative stress and perturbation of mitochondrial dynamics in the thymus of Gallus gallus

(2018) Juanjuan Liu et al.   CHEMOSPHERE

Elucidation of protective efficacy of Pentahydroxy flavone isolated from Madhuca indica against arsenite-induced cardiomyopathy: Role of Nrf-2, PPAR-γ, c-fos and c-jun

(2017) Anwesha A. Mukherjee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Epigenetic mechanisms underlying the toxic effects associated with arsenic exposure and the development of diabetes

(2017) Fazlullah Khan et al.   FOOD AND CHEMICAL TOXICOLOGY

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway

(2017) S. Miltonprabu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

All -Trans Retinoic Acid Ameliorates Arsenic-Induced Oxidative Stress and Apoptosis in the Rat Uterus by Modulating MAPK Signaling Proteins

(2017) Aniruddha Chatterjee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

(2017) Sunbin Ling et al.   Journal of Hematology & Oncology

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Acute arsenic exposure induces inflammatory responses and CD4+ T cell subpopulations differentiation in spleen and thymus with the involvement of MAPK, NF-kB, and Nrf2

(2017) Xiaoxu Duan et al.   MOLECULAR IMMUNOLOGY

Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer

(2017) Palak Shah et al.   MOLECULES

Arsenic downregulates tight junction claudin proteins through p38 and NF-κB in intestinal epithelial cell line, HT-29

(2017) Chang Hee Jeong et al.   TOXICOLOGY

Impaired autophagic flux and p62-mediated EMT are involved in arsenite-induced transformation of L-02 cells

(2017) Xinlu Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selenium triggers Nrf2-mediated protection against cadmium-induced chicken hepatocyte autophagy and apoptosis

(2017) Cong Zhang et al.   TOXICOLOGY IN VITRO

MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nrf2-mediated oxidative damage in human bronchial epithelial cells

(2017) Chengzhi Chen et al.   TOXICOLOGY LETTERS

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I

(2017) Sunbin Ling et al.   Cell Death & Disease

The involvement of Nrf2 in the protective effects of (-)-Epigallocatechin-3-gallate (EGCG) on NaAsO2-induced hepatotoxicity

(2017) Xiao-Dong Han et al.   Oncotarget

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2

(2017) Guanghong Xie et al.   Oncotarget

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damage in vivo

(2017) Chinthalapally V. Rao et al.   Oncotarget

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

Arsenite-induced stress granule formation is inhibited by elevated levels of reduced glutathione in West Nile virus-infected cells

(2017) Mausumi Basu et al.   PLoS Pathogens

Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes

(2017) Y Zhou et al.   Oncogenesis

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

Attenuative role of mangiferin in oxidative stress-mediated liver dysfunction in arsenic-intoxicated murines

(2016) Sukanya Saha et al.   BIOFACTORS

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

(2016) Elda Grabocka et al.   CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2

(2016) Ming Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy

(2016) Jiayu Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells

(2016) Sreetama Choudhury et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

SILAC-based quantitative proteomic analysis reveals widespread molecular alterations in human skin keratinocytes upon chronic arsenic exposure

(2016) Sartaj Ahmad Mir et al.   PROTEOMICS

From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect inCaenorhabditis elegans

(2016) Anthony L. Luz et al.   TOXICOLOGICAL SCIENCES

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

N-acetylcysteine and meso-2,3 dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats

(2016) Ahmed Abu El-Saad et al.   Drug Design Development and Therapy

Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway

(2016) Yue Zhang et al.   Oncotarget

PBPK modeling and simulation in drug research and development

(2016) Xiaomei Zhuang et al.   Acta Pharmaceutica Sinica B

2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells

(2015) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Nrf2 Activation Promotes Keratinocyte Survival during Early Skin Carcinogenesis via Metabolic Alterations

(2015) F. Rolfs et al.   CANCER RESEARCH

Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression

(2015) Glustein Pozo-Molina et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling

(2015) SG Li et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications

(2015) Deepak M. Kasote et al.   International Journal of Biological Sciences

Effects of glutathione on the in vivo metabolism and oxidative stress of arsenic in mice

(2015) Da Wang et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

p38α MAPK is required for arsenic-induced cell transformation

(2015) Hong-Gyum Kim et al.   MOLECULAR CARCINOGENESIS

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Targeting Pink1-Parkin-mediated mitophagy for treating liver injury

(2015) Jessica A. Williams et al.   PHARMACOLOGICAL RESEARCH

Importance of tyrosine phosphorylation in receptor kinase complexes

(2015) Alberto P. Macho et al.   TRENDS IN PLANT SCIENCE

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

(2015) Weiwei Wu et al.   PLoS One

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death

(2014) Xuezhong Gong et al.   ARCHIVES OF TOXICOLOGY

Inhibitory mechanism of dimercaptopropanesulfonic acid (DMPS) in the cellular biomethylation of arsenic

(2014) Shuping Wang et al.   BIOCHIMIE

Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation

(2014) Jiaying Sun et al.   CANCER LETTERS

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway

(2014) Jun He et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Protective effect of dietary flaxseed oil on arsenic-induced nephrotoxicity and oxidative damage in rat kidney

(2014) Sana Rizwan et al.   FOOD AND CHEMICAL TOXICOLOGY

Diallyl trisulfide ameliorates arsenic-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats

(2014) NC Sumedha et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: Differential roles of mitogen-activated protein kinases

(2014) Yongyong Hou et al.   TOXICOLOGY

Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation

(2014) Jinlong Shi et al.   TUMOR BIOLOGY

The Genesis of Tyrosine Phosphorylation

(2014) T. Hunter   Cold Spring Harbor Perspectives in Biology

Oxidative stress and MAPK involved into ATF2 expression in immortalized human urothelial cells treated by arsenic

(2013) Shengnan Liu et al.   ARCHIVES OF TOXICOLOGY

PBPK models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Protective effects of selenium on oxidative damage and oxidative stress related gene expression in rat liver under chronic poisoning of arsenic

(2013) Zhao Xu et al.   FOOD AND CHEMICAL TOXICOLOGY

Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner

(2013) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

Arsenic exposure induces the Warburg effect in cultured human cells

(2013) Fei Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction

(2013) Huihui Wang et al.   TOXICOLOGY IN VITRO

Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells

(2013) Fei Wang et al.   TOXICOLOGY LETTERS

NADPH oxidase-mitochondria axis-derived ROS mediate arsenite-induced HIF-1α stabilization by inhibiting prolyl hydroxylases activity

(2013) Ying-Na Li et al.   TOXICOLOGY LETTERS

Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways

(2013) Tien-Hui Lu et al.   TOXICOLOGY LETTERS

Arsenic-induced hepatic mitochondrial toxicity in rats and its amelioration by diallyl trisulfide

(2013) S. Miltonprabu et al.   TOXICOLOGY MECHANISMS AND METHODS

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Grape seed extract attenuates arsenic-induced nephrotoxicity in rats

(2013) JIANGONG ZHANG et al.   Experimental and Therapeutic Medicine

NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes

(2012) Hong-Yu Tseng et al.   ARCHIVES OF TOXICOLOGY

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways

(2012) Lisu Wang et al.   ARCHIVES OF TOXICOLOGY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation

(2012) Jun He et al.   EMBO REPORTS

Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes

(2012) Rui Zhao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Seven sirtuins for seven deadly diseases ofaging

(2012) Brian J. Morris   FREE RADICAL BIOLOGY AND MEDICINE

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective Role of Zinc in Ameliorating Arsenic-Induced Oxidative Stress and Histological Changes in Rat Liver

(2012) Ashok Kumar et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

The endoplasmic reticulum is a target organelle for trivalent dimethylarsinic acid (DMAIII)-induced cytotoxicity

(2012) Hua Naranmandura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells

(2012) Todd A. Stueckle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

(2011) Rohan Samarakoon et al.   CELL AND TISSUE RESEARCH

Arsenic-induced oxidative stress and its reversibility

(2011) Swaran J.S. Flora   FREE RADICAL BIOLOGY AND MEDICINE

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic: toxicity, oxidative stress and human disease

(2011) K. Jomova et al.   JOURNAL OF APPLIED TOXICOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Arsenic Exposure and Toxicology: A Historical Perspective

(2011) Michael F. Hughes et al.   TOXICOLOGICAL SCIENCES

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation

(2011) Xinjuan Pan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reduced Reactive Oxygen Species–Generating Capacity Contributes to the Enhanced Cell Growth of Arsenic-Transformed Epithelial Cells

(2010) Qingshan Chang et al.   CANCER RESEARCH

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

(2010) Brigit E. Riley et al.   JOURNAL OF CELL BIOLOGY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression

(2010) Rajdeep Chowdhury et al.   TOXICOLOGY LETTERS

Cellular uptake, subcellular distribution and toxicity of arsenic compounds in methylating and non-methylating cells

(2009) E. Dopp et al.   ENVIRONMENTAL RESEARCH

Biological Responses to Arsenic Compounds

(2009) Leonidas C. Platanias   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure

(2009) Elena V. Komissarova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reactive oxygen species and HIF-1 signalling in cancer

(2008) Alex Galanis et al.   CANCER LETTERS

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

(2008) Birgit Holst et al.   CURRENT OPINION IN BIOTECHNOLOGY

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

(2008) Jingbo Pi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure

(2008) Anna-Lena Lindberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction

(2008) Xiao-Jun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 Cl41 cells

(2008) Dongyun Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nonmalignant Respiratory Effects of Chronic Arsenic Exposure from Drinking Water among Never-Smokers in Bangladesh

(2007) Faruque Parvez et al.   ENVIRONMENTAL HEALTH PERSPECTIVES