Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation

(2021) Diana L. Bordin et al.   DNA REPAIR

Mitochondrial OXPHOS Biogenesis: Co-Regulation of Protein Synthesis, Import, and Assembly Pathways

(2020) Jia Xin Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration

(2019) Mariacarmela Allocca et al.   Science Signaling

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Plasticity of the Electrical Connectome of C. elegans

(2019) Abhishek Bhattacharya et al.   CELL

Mechanisms of mammalian mitochondrial transcription

(2019) Emilie Bouda et al.   PROTEIN SCIENCE

Mitophagy and Neuroprotection

(2019) Guofeng Lou et al.   TRENDS IN MOLECULAR MEDICINE

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins

(2019) Carlos Marques Palmeira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson’s disease

(2019) Yan Jiang et al.   BRAIN RESEARCH

Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans

(2018) Henok Kassahun et al.   DNA REPAIR

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans

(2018) Chenyin Wang et al.   NEUROBIOLOGY OF DISEASE

Modeling Parkinson’s Disease in C. elegans

(2018) Jason F. Cooper et al.   Journal of Parkinsons Disease

6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

(2018) Sarah-Lena Offenburger et al.   PLoS Genetics

Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

(2018) Silas Pinto et al.   Redox Biology

Rare genetic variation in mitochondrial pathways influences the risk for parkinson's disease

(2018) Johannes J. Gaare et al.   MOVEMENT DISORDERS

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Genome instability: Linking ageing and brain degeneration

(2017) Ari Barzilai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

El modelo de 6-hidroxidopamina y la fisiopatología parkinsoniana: nuevos hallazgos en un viejo modelo

(2017) D. Hernandez-Baltazar et al.   NEUROLOGIA

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

(2017) Evandro F. Fang et al.   Scientific Reports

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

(2016) Magdalena Misiak et al.   AGING CELL

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway

(2016) Li-De Su et al.   Insect Science

Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told byCaenorhabditis elegans

(2016) Matthew G. Andrusiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA

(2016) Morten Scheibye-Knudsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury

(2016) Amy Marie Yu et al.   Oncotarget

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

(2016) Sara Sepe et al.   Cell Reports

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

(2016) Øyvind Fensgård et al.   Aging-US

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Light and Hydrogen Peroxide Inhibit C. elegans Feeding through Gustatory Receptor Orthologs and Pharyngeal Neurons

(2015) Nikhil Bhatla et al.   NEURON

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

(2015) Peter Sykora et al.   NUCLEIC ACIDS RESEARCH

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

The interplay between mitochondria and autophagy and its role in the aging process

(2014) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21

(2014) Mingyi Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

(2014) Mohammad R. Ebrahimkhani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

α-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease

(2013) Stephen Mullin et al.   MOLECULAR NEUROBIOLOGY

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

(2013) Tanima SenGupta et al.   Nature Communications

Aag DNA Glycosylase Promotes Alkylation-Induced Tissue Damage Mediated by Parp1

(2013) Jennifer A. Calvo et al.   PLoS Genetics

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

Base Excision Repair in Physiology and Pathology of the Central Nervous System

(2012) Matthias Bosshard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life

(2012) Daniela Knoefler et al.   MOLECULAR CELL

To live or to die: a matter of processing damaged DNA termini in neurons

(2011) Sherif F. El-Khamisy   EMBO Molecular Medicine

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents

(2010) Hanne K. Skjeldam et al.   DNA REPAIR

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

The Anopheles gambiae Oxidation Resistance 1 (OXR1) Gene Regulates Expression of Enzymes That Detoxify Reactive Oxygen Species

(2010) Giovanna Jaramillo-Gutierrez et al.   PLoS One

Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region

(2009) Hironobu Morinaga et al.   DNA REPAIR

Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability

(2009) Chadi Zakaria et al.   DNA REPAIR