Herbal/Natural Compounds Resist Hallmarks of Brain Aging: From Molecular Mechanisms to Therapeutic Strategies

Protective Effects of Flavonoid Rutin Against Aminochrome Neurotoxicity

(2023) Fillipe Mendes De Araújo et al.   NEUROTOXICITY RESEARCH

Aging, Cellular Senescence, and Alzheimer’s Disease

(2022) Rui-Ming Liu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyanidin 3-O-β-Galactoside Alleviated Cognitive Impairment in Mice by Regulating Brain Energy Metabolism During Aging

(2022) Zhuoyan Fan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neurogenesis in aging and age-related neurodegenerative diseases

(2022) Luka Culig et al.   AGEING RESEARCH REVIEWS

Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

(2022) Ahmad Movahedpour et al.   CELL BIOCHEMISTRY AND FUNCTION

Panax ginseng and aging related disorders: A systematic review

(2022) Bárbara de Oliveira Zanuso et al.   EXPERIMENTAL GERONTOLOGY

Cellular senescence in the aging brain: A promising target for neurodegenerative diseases

(2022) Manas Ranjan Sahu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions

(2022) Mounica Soma et al.   MOLECULAR BIOLOGY REPORTS

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

(2022) Gavin Yong-Quan Ng et al.   GeroScience

Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced Alzheimer’s disease mice and glutamate-injured HT22 cells

(2022) Sixia Yang et al.   Chinese Medicine

Mitochondrial function and dynamics in neural stem cells and neurogenesis: Implications for neurodegenerative diseases

(2022) Patrícia Coelho et al.   AGEING RESEARCH REVIEWS

ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases

(2022) Jirong Lv et al.   AGEING RESEARCH REVIEWS

Tetrahydroxy stilbene glucoside alters neurogenesis and neuroinflammation to ameliorate radiation-associated cognitive disability via AMPK/Tet2

(2022) Bei-bei Miao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3

(2022) Dongmei Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

A pro-oxidant combination of resveratrol and copper down-regulates multiple biological hallmarks of ageing and neurodegeneration in mice

(2022) Kavita Pal et al.   Scientific Reports

Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice

(2022) Shao-Yu Zhou et al.   Neural Regeneration Research

Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila

(2021) Mikiko Oka et al.   iScience

Therapeutic effects of non-saponin fraction with rich polysaccharide from Korean red ginseng on aging and Alzheimer's disease

(2021) Soo Jung Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug-induced Parkinsonism: A strong predictor of idiopathic Parkinson’s disease

(2021) Sohyun Jeong et al.   PLoS One

Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation

(2021) Wei-Hsiang Hsu et al.   PHYTOMEDICINE

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement

(2021) Ya-Jen Chiu et al.   Aging-US

Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway

(2021) Xiaoxuan Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

(2021) Xiaoyan Xu et al.   Protein & Cell

Chrysophanol exerts neuroprotective effects via interfering with endoplasmic reticulum stress apoptotic pathways in cell and animal models of Alzheimer’s disease

(2021) Xinquan Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Brain aging mechanisms with mechanical manifestations

(2021) Yana Blinkouskaya et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Combination of β-Asarone and Icariin Inhibits Amyloid-β and Reverses Cognitive Deficits by Promoting Mitophagy in Models of Alzheimer’s Disease

(2021) Nanbu Wang et al.   Oxidative Medicine and Cellular Longevity

Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro

(2021) Gaofeng Qin et al.   Chinese Medicine

Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain

(2020) Shiu-Min Cheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

(2020) Maria Antonietta Panaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice through Modulation of Mitochondrial Respiration

(2020) Yunseon Jang et al.   Nutrients

Rosemary extract increases neuronal cell glucose uptake and activates AMPK

(2020) David C Baron et al.   Applied Physiology Nutrition and Metabolism

Non-Dopaminergic Treatments for Motor Control in Parkinson’s Disease: An Update

(2020) Paulina Gonzalez-Latapi et al.   CNS DRUGS

Icariin Attenuates Amyloid-β (Aβ)-Induced Neuronal Insulin Resistance Through PTEN Downregulation

(2020) Xiaomei Zou et al.   Frontiers in Pharmacology

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss

(2020) Margrethe A. Olesen et al.   Redox Biology

Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer’s disease

(2020) Abdelbasset Boubakri et al.   PLoS One

Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells

(2020) Yoonjung Kwon et al.   Cell Death & Disease

Flavonoids as a Natural Enhancer of Neuroplasticity—An Overview of the Mechanism of Neurorestorative Action

(2020) Natalia Cichon et al.   Antioxidants

The ZiBuPiYin recipe regulates proteomic alterations in brain mitochondria-associated ER membranes caused by chronic psychological stress exposure: Implications for cognitive decline in Zucker diabetic fatty rats

(2020) Huiying Xu et al.   Aging-US

Neurogenesis and brain aging

(2019) Nickolay K. Isaev et al.   REVIEWS IN THE NEUROSCIENCES

Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation

(2019) Yasuhisa Ano et al.   MOLECULES

Peroxisomal dysfunction in neurodegenerative diseases

(2019) Doo Sin Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner

(2019) Bei Zhang et al.   Journal of Neuroinflammation

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

(2019) Wesley Peng et al.   Neurotherapeutics

The role of lipid metabolism in aging, lifespan regulation, and age‐related disease

(2019) Adiv A. Johnson et al.   AGING CELL

The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration

(2019) Francesc X. Guix   JOURNAL OF NEUROSCIENCE RESEARCH

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

(2019) Aimée Parker et al.   Gut Microbes

Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling

(2019) Shin-Hae Lee et al.   Aging-US

Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice

(2019) Tabea Wiedenhoeft et al.   GeroScience

Saponins of Panax japonicus attenuate neuronal apoptosis through oxidative stress-related pathways and autophagy in natural aging rats

(2019) Jing-zhi Wan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mitigating peroxynitrite mediated mitochondrial dysfunction in aged rat brain by mitochondria-targeted antioxidant MitoQ

(2018) Arpan Kumar Maiti et al.   BIOGERONTOLOGY

Translational opportunities for amyloid-targeting fluorophores

(2018) Kevin J. Cao et al.   CHEMICAL COMMUNICATIONS

Anti-inflammatory effects of flavonoids in neurodegenerative disorders

(2018) Carmela Spagnuolo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effects of Ginsenoside Rf on Amyloid-β-Induced Neurotoxicity in vitro and in vivo

(2018) Yehong Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Age-related endolysosome dysfunction in the rat urothelium

(2018) Steven T. Truschel et al.   PLoS One

Pluripotent stem cell-based therapy for Parkinson’s disease: Current status and future prospects

(2018) Kai-C. Sonntag et al.   PROGRESS IN NEUROBIOLOGY

Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation in Vivo and in Vitro

(2018) Guo-Qing Wang et al.   Frontiers in Molecular Neuroscience

Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease

(2018) Débora Masini et al.   Frontiers in Neurology

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice

(2018) Nora E. Gray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Treatment of neurodegenerative disorders through the blood–brain barrier using nanocarriers

(2018) N. Poovaiah et al.   Nanoscale

Brain aging and neurodegeneration: from a mitochondrial point of view

(2017) Amandine Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease

(2017) Muhammet Ay et al.   JOURNAL OF NEUROCHEMISTRY

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

C1 neurons mediate a stress-induced anti-inflammatory reflex in mice

(2017) Chikara Abe et al.   NATURE NEUROSCIENCE

Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate

(2017) Anna Migdalska-Richards et al.   SYNAPSE

Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer’s Disease

(2017) et al.   Nutrients

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease

(2017) Chenxia Sheng et al.   Biomed Research International

Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins

(2017) Ayman G. Mustafa et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice

(2016) Anna Migdalska-Richards et al.   ANNALS OF NEUROLOGY

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction

(2016) Ji-Hong Moon et al.   Oncotarget

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

(2016) Rutong Ren et al.   Scientific Reports

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

(2016) Alvaro Sanchez-Martinez et al.   Scientific Reports

Parkinson's disease as a result of aging

(2015) Manuel Rodriguez et al.   AGING CELL

AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects

(2015) Diána Papp et al.   Autophagy

Carnosic acid protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease: Involvement of antioxidative enzymes induction

(2015) Chi-Rei Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice

(2015) Yi-Jing Chen et al.   CNS Neuroscience & Therapeutics

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

Potential Neuroprotective Activity of Ginseng in Parkinson’s Disease: A Review

(2014) Elena González-Burgos et al.   Journal of Neuroimmune Pharmacology

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

(2014) Franziska Richter et al.   Neurotherapeutics

Protective effect of curcuminoids on age-related mitochondrial impairment in female Wistar rat brain

(2013) Manisha Rastogi et al.   BIOGERONTOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study

(2013) Behzad Varamini et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Neurodegeneration, Neurogenesis, and Oxidative Stress

(2013) Renata Santos et al.   Oxidative Medicine and Cellular Longevity

Energy Intake and Exercise as Determinants of Brain Health and Vulnerability to Injury and Disease

(2012) Mark P. Mattson   Cell Metabolism

Neuroprotective effects of oral gallic acid against oxidative stress induced by 6-hydroxydopamine in rats

(2012) Mohammad Taghi Mansouri et al.   FOOD CHEMISTRY

Mitochondrial effects of Ginkgo biloba extract

(2012) Anne Eckert   INTERNATIONAL PSYCHOGERIATRICS

Role of Cytosolic Calcium-Dependent Phospholipase A2 in Alzheimer's Disease Pathogenesis

(2012) M. T. Gentile et al.   MOLECULAR NEUROBIOLOGY

Quercetin protects against the Aβ25–35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU

(2012) Rui Liu et al.   NEUROPHARMACOLOGY

Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway

(2012) K. Gopinath et al.   NEUROSCIENCE

Calcium homeostasis in aging neurons

(2012) Vassiliki Nikoletopoulou et al.   Frontiers in Genetics

L-Dopa Prodrugs: An Overview of Trends for Improving Parkinsons Disease Treatment

(2011) Antonio Di Stefano et al.   CURRENT PHARMACEUTICAL DESIGN

Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells

(2011) Shengquan Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The relationship between cortical sulcal variability and cognitive performance in the elderly

(2011) Tao Liu et al.   NEUROIMAGE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased mitochondrial DNA damage and decreased base excision repair in the auditory cortex of d-galactose-induced aging rats

(2010) Bei Chen et al.   MOLECULAR BIOLOGY REPORTS

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

The effects of age and sex on cortical sulci in the elderly

(2010) Tao Liu et al.   NEUROIMAGE

Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease

(2010) Ik Hyun Kwon et al.   NEUROSCIENCE LETTERS

Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy

(2010) Takuya Urano et al.   PHYTOTHERAPY RESEARCH

Anti-aging herbal medicine—How and why can they be used in aging-associated neurodegenerative diseases?

(2009) Yuen-Shan Ho et al.   AGEING RESEARCH REVIEWS

Novel nitrogen compounds enhance protection and repair of oxidative DNA damage in a neuronal cell model: Comparison with quercetin

(2009) João P. Silva et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice

(2009) Alexis M. Stranahan et al.   HIPPOCAMPUS

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

(2009) Tae Gen Son et al.   JOURNAL OF NEUROCHEMISTRY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

(2009) John W Steele et al.   Molecular Neurodegeneration

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats

(2008) T.A. Ajith et al.   EXPERIMENTAL GERONTOLOGY

Hormetic Dietary Phytochemicals

(2008) Tae Gen Son et al.   NEUROMOLECULAR MEDICINE