The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

Contemporary Formulations for Drug Delivery of Anticancer Bioactive Compounds

(2019) Darinka Gjorgieva Ackova et al.   Recent Patents on Anti-Cancer Drug Discovery

Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation

(2019) Jian Zhou et al.   NEUROCHEMICAL RESEARCH

Modulation of Biological Activities in Glioblastoma Mediated by Curcumin

(2019) Teresa Trotta et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Curcumin in Autoimmune and Rheumatic Diseases

(2019) Melissa Yang et al.   Nutrients

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling

(2019) Muhammad Ikram et al.   Nutrients

The multiple roles of exosomes in Parkinson's disease: an overview

(2019) Chiara Porro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

(2019) YongYue Gao et al.   Frontiers in Neuroscience

Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition

(2019) Giada Catalogna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Microglia-derived extracellular vesicles in Alzheimer’s Disease: A double-edged sword

(2018) Teresa Trotta et al.   BIOCHEMICAL PHARMACOLOGY

One molecule, many targets and numerous effects: the pleiotropy of curcumin lies in its chemical structure

(2018) Mahdi Hatamipour et al.   CURRENT PHARMACEUTICAL DESIGN

TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease

(2018) Manru Ren et al.   EXPERIMENTAL NEUROLOGY

Curcumin Prevents Acute Neuroinflammation and Long-Term Memory Impairment Induced by Systemic Lipopolysaccharide in Mice

(2018) Vincenzo Sorrenti et al.   Frontiers in Pharmacology

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nutraceuticals: A paradigm of proactive medicine

(2017) Antonello Santini et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Diagnostic and Therapeutic Potential of Exosomes in Cancer: The Beginning of a New Tale?

(2017) Hamed Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open-label Parallel-arm Study

(2017) Sreeraj Gopi et al.   PHYTOTHERAPY RESEARCH

Curcumin inhibits cancer progression through regulating expression of microRNAs

(2017) Siying Zhou et al.   TUMOR BIOLOGY

Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experimental Cerebral Malaria

(2017) Chaitanya Dende et al.   Scientific Reports

Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages

(2017) Weishan Fang et al.   Scientific Reports

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases

(2016) Ajaikumar B Kunnumakkara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP+)-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway

(2016) Song Yu et al.   CELL STRESS & CHAPERONES

Circulating microRNAs as Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives

(2016) Hamed Mirzaei et al.   CURRENT MEDICINAL CHEMISTRY

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

(2016) Anuradha Kalani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Folic Acid Is Able to Polarize the Inflammatory Response in LPS Activated Microglia by Regulating Multiple Signaling Pathways

(2016) Antonia Cianciulli et al.   MEDIATORS OF INFLAMMATION

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Molecular targets of curcumin for cancer therapy: an updated review

(2016) Pandima Devi Kasi et al.   TUMOR BIOLOGY

Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation

(2016) Xiao Li et al.   EBioMedicine

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

(2015) N. Greeshma et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The potential for circulating microRNAs in the diagnosis of myocardial infarction: a novel approach to disease diagnosis and treatment

(2015) Sharareh Gholamin et al.   CURRENT PHARMACEUTICAL DESIGN

Triggering receptor expressed on myeloid cells-2 fine-tunes inflammatory responses in murine Gram-negative sepsis

(2015) Riem Gawish et al.   FASEB JOURNAL

Microvesicles in the brain: Biomarker, messenger or mediator?

(2015) Chiara Porro et al.   JOURNAL OF NEUROIMMUNOLOGY

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

(2015) Dongdong Ti et al.   Journal of Translational Medicine

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

(2015) Anuradha Kalani et al.   Neural Regeneration Research

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Astrocyte: Powerhouse and Recycling Center

(2015) Bruno Weber et al.   Cold Spring Harbor Perspectives in Biology

Astrocyte Regulation of Blood Flow in the Brain

(2015) Brian A. MacVicar et al.   Cold Spring Harbor Perspectives in Biology

Topology, dynamics, and heterogeneity in immune signaling

(2015) J. Taylor Webb et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Extracellular vesicles: New players in cardiovascular diseases

(2014) Abderahim Gaceb et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Exosomal miRNAs as potential biomarkers of cardiovascular risk in children

(2014) Abdelnaby Khalyfa et al.   Journal of Translational Medicine

Curcumin as a wound healing agent

(2014) Dania Akbik et al.   LIFE SCIENCES

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain

(2014) Haneul Noh et al.   NEUROCHEMISTRY INTERNATIONAL

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins

(2013) Ota Fekonja et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Pro-inflammatory effect of cystic fibrosis sputum microparticles in the murine lung

(2013) Chiara Porro et al.   Journal of Cystic Fibrosis

The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats

(2013) YI WANG et al.   Molecular Medicine Reports

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

Advanced Glycation End Products Induce Peroxisome Proliferator-Activated Receptor γ Down-Regulation-Related Inflammatory Signals in Human Chondrocytes via Toll-Like Receptor-4 and Receptor for Advanced Glycation End Products

(2013) Ying Ju Chen et al.   PLoS One

Changes in toll-like receptor (TLR)4–NFκB–IL1β signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis

(2013) Yu-Feng Qing et al.   RHEUMATOLOGY INTERNATIONAL

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Viruses and neurodegeneration

(2013) Li Zhou et al.   Virology Journal

Latest advances in connective tissue disorders

(2013) Vijay Rao et al.   Therapeutic Advances in Musculoskeletal Disease

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Curcumin in inflammatory diseases

(2012) Adeeb Shehzad et al.   BIOFACTORS

Emerging Roles for Modulation of microRNA Signatures in Cancer Chemoprevention

(2012) K. Neelakandan et al.   CURRENT CANCER DRUG TARGETS

Ubiquitination in signaling to and activation of IKK

(2012) Zhijian J. Chen   IMMUNOLOGICAL REVIEWS

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes

(2012) Delfin A.A. Raj et al.   KIDNEY INTERNATIONAL

A systematic approach to exosome-based translational nanomedicine

(2012) Joshua L. Hood et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

TLR4-mediated IL-12 production enhances IFN-γ and IL-1β production, which inhibits TGF-β production and promotes antibody-induced joint inflammation

(2012) Hye Kim et al.   ARTHRITIS RESEARCH & THERAPY

Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage

(2012) Hatice Hasturk et al.   Frontiers in Immunology

RNA-containing Exosomes in Human Nasal Secretions

(2011) Cecilia Lässer et al.   American Journal of Rhinology & Allergy

Exosome nanotechnology: An emerging paradigm shift in drug delivery

(2011) Samira Lakhal et al.   BIOESSAYS

Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice

(2011) Liu Zhongfa et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts

(2011) Addolorata Corrado et al.   CLINICAL AND EXPERIMENTAL MEDICINE

TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells

(2011) Hiroaki Ito et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1

(2011) Pu Wang et al.   FASEB JOURNAL

Curcumin and its nano-formulation: The kinetics of tissue distribution and blood–brain barrier penetration

(2011) Yin-Meng Tsai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of nutraceuticals in human health

(2011) Lipi Das et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

MicroRNAs, diet, and cancer: New mechanistic insights on the epigenetic actions of phytochemicals

(2011) Mansi A. Parasramka et al.   MOLECULAR CARCINOGENESIS

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

(2011) Purusotam Basnet et al.   MOLECULES

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

(2011) Ling Zhao et al.   NUTRITION REVIEWS

Curcumin in Cancer Chemoprevention: Molecular Targets, Pharmacokinetics, Bioavailability, and Clinical Trials

(2010) Adeeb Shehzad et al.   ARCHIV DER PHARMAZIE

Exploring the LPS/TLR4 signal pathway with small molecules

(2010) Francesco Peri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Endogenous toll-like receptor ligands and their biological significance

(2010) Li Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Moesin-induced signaling in response to lipopolysaccharide in macrophages

(2010) K. H. Zawawi et al.   JOURNAL OF PERIODONTAL RESEARCH

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients

(2009) M. Jagannathan et al.   JOURNAL OF IMMUNOLOGY

The molecular basis of the host response to lipopolysaccharide

(2009) Clare E. Bryant et al.   NATURE REVIEWS MICROBIOLOGY

Advances of Cancer Therapy by Nanotechnology

(2009) Xu Wang et al.   Cancer Research and Treatment

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells

(2008) Juan Pablo Nicola et al.   ENDOCRINOLOGY

Vascular cell responsiveness to Toll-like receptor ligands in carotid atheroma

(2008) C. Erridge et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Expression of TLR4 and CD14 in the Central Nervous System (CNS) in a MPTP Mouse Model of Parkinson's-Like Disease

(2008) Maria Antonietta Panaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

(2008) Stefan F. Martin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Inducible Toll-like Receptor and NF-κB Regulatory Pathway Expression in Human Adipose Tissue

(2008) Olga I. Vitseva et al.   Obesity

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY