Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation in Vivo and in Vitro

The science and ethics of cell-based therapies for Parkinson's disease

(2017) C.R. Towns   PARKINSONISM & RELATED DISORDERS

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

(2017) Enrico Raffaele Fantoni et al.   EJNMMI Research

The Protective Effects of Icariin against the Homocysteine-Induced Neurotoxicity in the Primary Embryonic Cultures of Rat Cortical Neurons

(2016) Xiao-Ang Li et al.   MOLECULES

Curcumin improves neurofunctions of 6-OHDA-induced parkinsonian rats

(2016) Shilei Song et al.   PATHOLOGY RESEARCH AND PRACTICE

The impact of 1MeTIQ on the dopaminergic system function in the 6-OHDA model of Parkinson’s disease

(2016) Agnieszka Wąsik et al.   Pharmacological Reports

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway

(2016) Haroon Badshah et al.   Scientific Reports

Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson’s disease examined using persistent homology-based analysis

(2016) Hyung-Jun Im et al.   Scientific Reports

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

AnIn VivoMicrodialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats

(2014) Jinfeng Hou et al.   Biomed Research International

Clozapine Protects Dopaminergic Neurons from Inflammation-Induced Damage by Inhibiting Microglial Overactivation

(2011) Xiaoming Hu et al.   Journal of Neuroimmune Pharmacology

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and immunohistochemical studies

(2010) Gulrana Khuwaja et al.   BRAIN RESEARCH

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Inhibition of I B Kinase-  Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity

(2010) F. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats

(2010) J. Guo et al.   PHYTOMEDICINE

Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1β by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells

(2009) Y Choi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY