Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3

Hypertrophic Preconditioning Attenuates Myocardial Ischaemia‐Reperfusion Injury by Modulating SIRT3‐SOD2‐mROS‐Dependent Autophagy

(2021) Lei‐Lei Ma et al.   CELL PROLIFERATION

Sirt3-mediated mitochondrial dysfunction is involved in fluoride-induced cognitive deficits

(2021) Dongmei Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Critical role of AMPK in redox regulation under glucose starvation

(2019) Yi Ren et al.   Redox Biology

Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation

(2019) Kun Cao et al.   Alzheimers Research & Therapy

Low-to-moderate fluoride exposure, relative mitochondrial DNA levels, and dental fluorosis in Chinese children

(2019) Guoyu Zhou et al.   ENVIRONMENT INTERNATIONAL

Honokiol Attenuates the Memory Impairments, Oxidative Stress, Neuroinflammation, and GSK-3β Activation in Vascular Dementia Rats

(2019) Si Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

A validated ultra-HPLC–MS/MS method for determination of honokiol in human plasma and its application to a clinical pharmacokinetic study

(2019) Quankun Zhuang et al.   Bioanalysis

Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation

(2019) Dongmei Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acute fluoride exposure alters myocardial redox and inflammatory markers in rats

(2019) Lakshmikanthan Panneerselvam et al.   MOLECULAR BIOLOGY REPORTS

Effects of long-term fluoride exposure on cognitive ability and the underlying mechanisms: Role of autophagy and its association with apoptosis

(2019) Guoyu Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response

(2019) Fasano et al.   Cells

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis

(2019) Anushka Chakravorty et al.   Frontiers in Aging Neuroscience

Nanoparticulated Honokiol Mitigates Cisplatin-Induced Chronic Kidney Injury by Maintaining Mitochondria Antioxidant Capacity and Reducing Caspase 3-Associated Cellular Apoptosis

(2019) Hung-Ting Liu et al.   Antioxidants

Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice

(2019) Hong-wei Wang et al.   CHEMOSPHERE

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

(2019) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells

(2019) Hong-wei Wang et al.   ENVIRONMENTAL POLLUTION

Honokiol Alleviates Cognitive Deficits of Alzheimer’s Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3

(2018) Haitao Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Honokiol ameliorates cognitive impairment by attenuating amyloidosis and neuroinflammation in a transgenic mouse model of Alzheimer's disease

(2018) DONGMEI WANG et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury

(2018) Xiaoxin Guo et al.   NEUROBIOLOGY OF DISEASE

Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats

(2018) Jingwei Zheng et al.   Frontiers in Neuroscience

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

(2018) Clara Hiu-Ling Hung et al.   Redox Biology

Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice

(2017) Dongmei Wang et al.   EXPERIMENTAL GERONTOLOGY

Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway

(2017) Chao Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

(2017) Lan Guo et al.   JOURNAL OF ALZHEIMERS DISEASE

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway

(2017) Shu-Guang Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway

(2017) Chao Song et al.   Scientific Reports

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+elevation

(2016) Xiaojuan Han et al.   AGING CELL

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS

(2016) Haemin Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A cannabinoid link between mitochondria and memory

(2016) Etienne Hebert-Chatelain et al.   NATURE

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

(2015) Huifeng Pi et al.   Autophagy

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

The Pharmacokinetics and Tissue Distribution of Honokiol and its Metabolites in Rats

(2015) Wang Jun-jun et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling

(2015) Maiko Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway

(2015) Sasidharan Padmaja Divya et al.   TOXICOLOGICAL SCIENCES

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Pharmacokinetics of honokiol after intravenous guttae in beagle dogs assessed using ultra-performance liquid chromatography-tandem mass spectrometry

(2014) Yi Liang et al.   BIOMEDICAL CHROMATOGRAPHY

Mitochondrial reactive oxygen species production and elimination

(2014) Alexander Nickel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Developmental and maintenance defects in Rett syndrome neurons identified by a new mouse staging system in vitro

(2014) Gabriele Baj et al.   Frontiers in Cellular Neuroscience

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

(2014) X Zhou et al.   Cell Death & Disease

Suppression of Mitochondrial Oxidative Phosphorylation and TCA Enzymes in Discrete Brain Regions of Mice Exposed to High Fluoride: Amelioration by Panax ginseng (Ginseng) and Lagerstroemia speciosa (Banaba) Extracts

(2013) P. Mahaboob Basha et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ethanol and age enhances fluoride toxicity through oxidative stress and mitochondrial dysfunctions in rat intestine

(2013) Shailender Singh Chauhan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Studying synapses in human brain with array tomography and electron microscopy

(2013) Kevin R Kay et al.   Nature Protocols

Neuro-Modulating Effects of Honokiol: A Review

(2013) Anna Woodbury et al.   Frontiers in Neurology

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

(2012) Anna L. Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway

(2012) J.-W. Lin et al.   NEURO-ONCOLOGY

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol

(2011) Xian-Huo Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

(2009) Nagalingam R. Sundaresan et al.   JOURNAL OF CLINICAL INVESTIGATION

Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress

(2009) Eliud A. García-Montalvo et al.   TOXICOLOGY

Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model

(2008) Qi-qi Jiang et al.   BMC CANCER

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA