The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
Authors
Keywords
-
Journal
AGING CELL
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-09-27
DOI
10.1111/acel.13048
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Plasma lipidome variation during the second half of the human lifespan is associated with age and sex but minimally with BMI
- (2019) Matthew Wai Kin Wong et al. PLoS One
- Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses
- (2019) Bérénice A. Benayoun et al. GENOME RESEARCH
- The Genetics of Aging: A Vertebrate Perspective
- (2019) Param Priya Singh et al. CELL
- 17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males
- (2019) Michael Garratt et al. AGING CELL
- Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging
- (2019) Richard D. Semba et al. AGING CELL
- Fatty acid transport protein 2 reprograms neutrophils in cancer
- (2019) Filippo Veglia et al. NATURE
- Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice
- (2019) Mitsukuni Yoshida et al. Cell Metabolism
- Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
- (2019) Bhagirath Chaurasia et al. SCIENCE
- 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial
- (2019) William E Kraus et al. Lancet Diabetes & Endocrinology
- Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice
- (2018) Michael Garratt et al. AGING CELL
- An epigenetic biomarker of aging for lifespan and healthspan
- (2018) Morgan E. Levine et al. Aging-US
- AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation
- (2018) Qi Wang et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
- (2018) Rozenn N. Lemaitre et al. DIABETES
- The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review
- (2018) Jacqueline Innes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeted Metabolomics Shows Low Plasma Lysophosphatidylcholine 18:2 Predicts Greater Decline of Gait Speed in Older Adults: The Baltimore Longitudinal Study of Aging
- (2018) Marta Gonzalez-Freire et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- High density lipoprotein cholesterol and cancer: Marker or causative?
- (2018) Matteo Pirro et al. PROGRESS IN LIPID RESEARCH
- Medium-Chain Fatty Acids, Beta-Hydroxybutyric Acid and Genetic Modulation of the Carnitine Shuttle Are Protective in a Drosophila Model of ALS Based on TDP-43
- (2018) Ernesto Manzo et al. Frontiers in Molecular Neuroscience
- Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders
- (2018) Alba Di Pardo et al. Frontiers in Neuroscience
- Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks
- (2018) Theingi Aung et al. JAMA Cardiology
- Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes
- (2018) Audrey Griveau et al. AGING CELL
- Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements
- (2018) Emma Derbyshire Nutrients
- Turning back time with emerging rejuvenation strategies
- (2018) Salah Mahmoudi et al. NATURE CELL BIOLOGY
- Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration
- (2018) Johanna M. Colijn et al. OPHTHALMOLOGY
- A Clinical Trial Using Methylation Age to Evaluate Current Antiaging Practices
- (2018) Josh Mitteldorf REJUVENATION RESEARCH
- Linking Lipid Metabolism to Chromatin Regulation in Aging
- (2018) Katharina Papsdorf et al. TRENDS IN CELL BIOLOGY
- Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans
- (2017) Yumiko Nakatani et al. EUROPEAN JOURNAL OF NUTRITION
- Omega-3 Fatty Acids in Rheumatic Diseases
- (2017) Umair Akbar et al. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
- Lipoic acid metabolism and mitochondrial redox regulation
- (2017) Ashley Solmonson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta-analysis of randomised placebo-control human clinical trials
- (2017) S. AbuMweis et al. JOURNAL OF HUMAN NUTRITION AND DIETETICS
- Whales, lifespan, phospholipids, and cataracts
- (2017) Douglas Borchman et al. JOURNAL OF LIPID RESEARCH
- Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging
- (2017) Alexandra M V Wennberg et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan
- (2017) Shuo Han et al. NATURE
- Triglycerides are negatively correlated with cognitive function in nondemented aging adults.
- (2017) Vishnu Parthasarathy et al. NEUROPSYCHOLOGY
- Current insights into functions of phospholipase A2 receptor in normal and cancer cells: More questions than answers
- (2017) Olga Sukocheva et al. SEMINARS IN CANCER BIOLOGY
- Sphingolipids and Lipoproteins in Health and Metabolic Disorders
- (2017) Jahangir Iqbal et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
- (2017) Peter K. Joshi et al. Nature Communications
- Caloric restriction improves health and survival of rhesus monkeys
- (2017) Julie A. Mattison et al. Nature Communications
- Developmental diet regulates Drosophila lifespan via lipid autotoxins
- (2017) M. Irina Stefana et al. Nature Communications
- Lipid and Alzheimer’s disease genes associated with healthy aging and longevity in healthy oldest-old
- (2017) Lauren C. Tindale et al. Oncotarget
- Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans
- (2017) Jason P. Chan et al. Frontiers in Genetics
- The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age
- (2017) Séverine Trabado et al. PLoS One
- Associations of triglyceride levels with longevity and frailty: A Mendelian randomization analysis
- (2017) Zuyun Liu et al. Scientific Reports
- Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer
- (2016) Randy Strong et al. AGING CELL
- Fish oil supplements, longevity and aging
- (2016) João de Magalhães et al. Aging-US
- Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
- (2016) Yu Yamazaki et al. CNS DRUGS
- Biomarkers of lipid peroxidation related to hypertension in aging
- (2016) Hakan Yavuzer et al. HYPERTENSION RESEARCH
- A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans
- (2016) Mariona Jové et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Genetic landscape of APOE in human longevity revealed by high-throughput sequencing
- (2016) Seungjin Ryu et al. MECHANISMS OF AGEING AND DEVELOPMENT
- NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
- (2016) H. Zhang et al. SCIENCE
- Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
- (2016) Wael Al-Zoughbi et al. Oncotarget
- Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants
- (2016) Robert J. Shmookler Reis et al. Aging-US
- Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
- (2016) Ryan S. Streeper et al. Aging-US
- Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila
- (2016) Julia Hoffmann et al. Aging-US
- D-beta-hydroxybutyrate extends lifespan in C. elegans
- (2016) Clare Edwards et al. Aging-US
- Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
- (2016) Ivan Montoliu et al. Aging-US
- Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ
- (2015) Chathyan Pararasa et al. AGING CELL
- Autophagy-mediated longevity is modulated by lipoprotein biogenesis
- (2015) Nicole E. Seah et al. Autophagy
- Loss ofPLA2G6leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
- (2015) Kerri J. Kinghorn et al. BRAIN
- Omega-3 polyunsaturated fatty acids and brain aging
- (2015) Isabelle Denis et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Unsaturated fatty acids induce non-canonical autophagy
- (2015) M. Niso-Santano et al. EMBO JOURNAL
- Increased Akt signaling in the mosquito fat body increases adult survivorship
- (2015) Anam J. Arik et al. FASEB JOURNAL
- Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
- (2015) Darryl P Leong et al. LANCET
- MARK-AGE biomarkers of ageing
- (2015) Alexander Bürkle et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans
- (2015) Shan Su et al. PHYTOCHEMISTRY
- Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress inCaenorhabditis elegans
- (2015) Dana A. Lynn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans
- (2015) A. Folick et al. SCIENCE
- NAD+ in aging, metabolism, and neurodegeneration
- (2015) E. Verdin SCIENCE
- Lipid Profiles and Signals for Long Life
- (2015) Elizabeth A. Schroeder et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- D-ß-hydroxybutyrate: an anti-aging ketone body
- (2015) Clare Edwards et al. Oncotarget
- Diacylglycerol lipaseregulates lifespan and oxidative stress response by inversely modulating TOR signaling inDrosophilaandC. elegans
- (2014) Yen-Hung Lin et al. AGING CELL
- Decreased lipid absorption due to reduced pancreatic lipase activity in aging male mice
- (2014) Kazushi Yamamoto et al. BIOGERONTOLOGY
- Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research
- (2014) João Pedro de Magalhães CELL CYCLE
- Phosphatidic acid phospholipase A1 mediates ER–Golgi transit of a family of G protein–coupled receptors
- (2014) Govind Kunduri et al. JOURNAL OF CELL BIOLOGY
- The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice
- (2014) José A. López-Domínguez et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Fat body, fat pad and adipose tissues in invertebrates and vertebrates: the nexus
- (2014) Odunayo Azeez et al. Lipids in Health and Disease
- Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans
- (2014) Roy G. Cutler et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Plasma phospholipids identify antecedent memory impairment in older adults
- (2014) Mark Mapstone et al. NATURE MEDICINE
- Extended lifespan and reduced adiposity in mice lacking the FAT10 gene
- (2014) A. Canaan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phospholipid Synthesis and Transport in Mammalian Cells
- (2014) Jean E. Vance TRAFFIC
- Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
- (2014) Marko Brankatschk et al. eLife
- Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
- (2013) David E. Harrison et al. AGING CELL
- Lipidomics of familial longevity
- (2013) Vanessa Gonzalez-Covarrubias et al. AGING CELL
- Aging affects high-density lipoprotein composition and function
- (2013) Michael Holzer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Sphingolipids and lifespan regulation
- (2013) Xinhe Huang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- -6 Polyunsaturated fatty acids extend life span through the activation of autophagy
- (2013) E. J. O'Rourke et al. GENES & DEVELOPMENT
- Fish oil changes the lifespan of Caenorhabditis elegans via lipid peroxidation
- (2013) Soko Sugawara et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy
- (2013) M. J. H. Coenen et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans
- (2013) Mai-Britt Mosbech et al. PLoS One
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Plasma long-chain free fatty acids predict mammalian longevity
- (2013) Mariona Jové et al. Scientific Reports
- Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids
- (2012) Deepika Nehra et al. AGING CELL
- The extreme longevity ofArctica islandicais associated with increased peroxidation resistance in mitochondrial membranes
- (2012) Daniel Munro et al. AGING CELL
- Autophagy links lipid metabolism to longevity inC. elegans
- (2012) Louis R. Lapierre et al. Autophagy
- Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
- (2012) Ana Ortega-Molina et al. Cell Metabolism
- Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease?
- (2012) Michelle M Mielke et al. Clinical Lipidology
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- (2012) W.-L. Chen et al. DIABETOLOGIA
- Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging
- (2012) Z. S. Tan et al. NEUROLOGY
- ASM-3 Acid Sphingomyelinase Functions as a Positive Regulator of the DAF-2/AGE-1 Signaling Pathway and Serves as a Novel Anti-Aging Target
- (2012) Yongsoon Kim et al. PLoS One
- LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease
- (2012) Carlos Spuch et al. Frontiers in Physiology
- Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans
- (2011) Louis R. Lapierre et al. CURRENT BIOLOGY
- N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans
- (2011) Mark Lucanic et al. NATURE
- Lifespan-Extending Effects of Royal Jelly and Its Related Substances on the Nematode Caenorhabditis elegans
- (2011) Yoko Honda et al. PLoS One
- The metabolic footprint of aging in mice
- (2011) Riekelt H. Houtkooper et al. Scientific Reports
- Lipid metabolism in long-lived families: the Leiden Longevity Study
- (2010) Anika A. M. Vaarhorst et al. AGE
- Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity
- (2010) Qiong Yang et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Fatty acid regulation of hepatic lipid metabolism
- (2010) Donald B Jump CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- The impact of larval and adult dietary restriction on lifespan, reproduction and growth in the mosquito Aedes aegypti
- (2010) Teresa K. Joy et al. EXPERIMENTAL GERONTOLOGY
- A role of apolipoprotein D in triglyceride metabolism
- (2010) German Perdomo et al. JOURNAL OF LIPID RESEARCH
- CD95 promotes tumour growth
- (2010) Lina Chen et al. NATURE
- Increase in sphingolipid catabolic enzyme activity during aging
- (2009) Santosh J Sacket et al. ACTA PHARMACOLOGICA SINICA
- PON1 is a longevity gene: Results of a meta-analysis
- (2009) Francesco Lescai et al. AGEING RESEARCH REVIEWS
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
- (2009) Daniel K. Nomura et al. CELL
- The Ubiquitin-Like Protein FAT10 Mediates NF- B Activation
- (2009) P. Gong et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Regulation of Fat Cell Mass by Insulin in Drosophila melanogaster
- (2009) J. R. DiAngelo et al. MOLECULAR AND CELLULAR BIOLOGY
- An Evolutionary Genome Scan for Longevity-Related Natural Selection in Mammals
- (2009) R. W. Jobson et al. MOLECULAR BIOLOGY AND EVOLUTION
- Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase
- (2009) V. Menuz et al. SCIENCE
- Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
- (2009) C. Selman et al. SCIENCE
- Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1
- (2008) Patricia Tedesco et al. AGE
- Visceral adipose tissue modulates mammalian longevity
- (2008) Radhika Muzumdar et al. AGING CELL
- Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
- (2008) Maria D. Ganfornina et al. AGING CELL
- Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism
- (2008) Yuguang Shi et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Compounds that confer thermal stress resistance and extended lifespan
- (2008) Michael G. Benedetti et al. EXPERIMENTAL GERONTOLOGY
- Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A2 Deficiency in Mice: A Model of Human Neurodegenerative Disease
- (2008) K. Shinzawa et al. JOURNAL OF NEUROSCIENCE
- Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila
- (2008) J. Muffat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
- (2008) M. C. Wang et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation