Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro

Neurotoxic Soluble Amyloid Oligomers Drive Alzheimer’s Pathogenesis and Represent a Clinically Validated Target for Slowing Disease Progression

(2021) Martin Tolar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

(2021) Fan Wu et al.   Chinese Medicine

Shenzhiling oral solution promotes myelin repair through PI3K/Akt-mTOR pathway in STZ-induced SAD mice

(2021) Gaofeng Qin et al.   3 Biotech

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Functions of Cytochrome c Oxidase Assembly Factors

(2020) Shane A. Watson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization and hypoglycemic effect of a neutral polysaccharide extracted from the residue of Codonopsis Pilosula

(2018) Wei Liu et al.   CARBOHYDRATE POLYMERS

Atrophy in Distributed Networks Predicts Cognition in Alzheimer’s Disease and Type 2 Diabetes

(2018) Stephanie S. Buss et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of the herbal formulation Shen-Zhi-Ling on an APP/PS1 mouse model of Alzheimer's disease by modulating the biliverdin reductase/heme oxygenase 1 system

(2017) Sanli Xing et al.   Experimental and Therapeutic Medicine

Risk of Incident Alzheimer's Disease in Diabetic Patients: A Systematic Review of Prospective Trials

(2017) Daniel Kopf et al.   JOURNAL OF ALZHEIMERS DISEASE

Glycyrrhetinic acid protects H9c2 cells from oxygen glucose deprivation-induced injury through the PI3K/AKt signaling pathway

(2016) Liqin Wang et al.   Journal of Natural Medicines

Upregulation of Mitochondrial Content in Cytochrome c Oxidase Deficient Fibroblasts

(2016) Aviram Kogot-Levin et al.   PLoS One

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Poligapolide, a PI3K/Akt Inhibitor in Immunodeficiency Virus Type 1 TAT-Transduced CHME5 Cells, Isolated from the Rhizome of Polygala tenuifolia

(2014) Sul-Young Yoo et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Hexokinase 1 blocks apoptotic signals at the mitochondria

(2013) Anja Schindler et al.   CELLULAR SIGNALLING

ATP synthesis and storage

(2012) Massimo Bonora et al.   Purinergic Signalling

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Brain glucose transporters,O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease

(2009) Ying Liu et al.   JOURNAL OF NEUROCHEMISTRY

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE