Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

(2021) Yanan Chen et al.   eLife

Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway

(2021) Shira Mencer et al.   Translational Psychiatry

Amyotrophic lateral sclerosis: a clinical review

(2020) P. Masrori et al.   EUROPEAN JOURNAL OF NEUROLOGY

Rapamycin for longevity: opinion article

(2019) Mikhail V. Blagosklonny   Aging-US

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Abnormal mTOR Activation in Autism

(2018) Kellen D. Winden et al.   Annual Review of Neuroscience

ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury

(2018) Xiupeng Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K/Akt/mTOR signalling pathway to improve functional recovery after traumatic brain injury

(2018) Kebin Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Role of mTOR Complexes in Neurogenesis

(2018) Francesca LiCausi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of long-term rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice

(2018) Yan-Ying Fan et al.   NEUROSCIENCE LETTERS

Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis

(2018) Santa Mammana et al.   Oncotarget

Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention

(2018) Li Zhang et al.   Frontiers in Molecular Neuroscience

Management of behavioral and psychological symptoms in people with Alzheimer's disease: an international Delphi consensus

(2018) Helen C. Kales et al.   INTERNATIONAL PSYCHOGERIATRICS

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

(2018) Fatemeh N. Emamzadeh et al.   Frontiers in Neuroscience

Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis

(2017) Sabrina Giacoppo et al.   FITOTERAPIA

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells

(2017) Russell G. Jones et al.   IMMUNITY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Functional Changes after Recombinant Human Growth Hormone Replacement in Patients with Chronic Traumatic Brain Injury and Abnormal Growth Hormone Secretion

(2017) Kurt A. Mossberg et al.   JOURNAL OF NEUROTRAUMA

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Posttraumatic administration of a sub-anesthetic dose of ketamine exerts neuroprotection via attenuating inflammation and autophagy

(2017) C.-Q. Wang et al.   NEUROSCIENCE

Multiple sclerosis: Pathology, diagnosis and treatments

(2017) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Rapalogs Efficacy Relies on the Modulation of Antitumor T-cell Immunity

(2016) Laurent Beziaud et al.   CANCER RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Enduring changes in tonic GABA A receptor signaling in dentate granule cells after controlled cortical impact brain injury in mice

(2016) Jeffery A. Boychuk et al.   EXPERIMENTAL NEUROLOGY

Differential effects of rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice

(2016) Corwin R. Butler et al.   EXPERIMENTAL NEUROLOGY

Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation

(2016) Natalie M. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Beneficial Effects of Early mTORC1 Inhibition after Traumatic Brain Injury

(2016) Ina Nikolaeva et al.   JOURNAL OF NEUROTRAUMA

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

The incidence of ARDS and associated mortality in severe TBI using the Berlin definition

(2016) Imoigele P. Aisiku et al.   Journal of Trauma and Acute Care Surgery

mTOR Signaling in Parkinson’s Disease

(2016) Ai-ping Lan et al.   NEUROMOLECULAR MEDICINE

Inflammatory neuroprotection following traumatic brain injury

(2016) M. V. Russo et al.   SCIENCE

Biomedical Potential of mTOR Modulation by Nanoparticles

(2016) Laura Hulea et al.   TRENDS IN BIOTECHNOLOGY

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

(2016) Carla Garza-Lombó et al.   Frontiers in Cellular Neuroscience

Epidemiology of Global Pediatric Traumatic Brain Injury: Qualitative Review

(2016) Michael C. Dewan et al.   World Neurosurgery

The incidence of ARDS and associated mortality in severe TBI using the Berlin definition

(2016) Imoigele P. Aisiku et al.   Journal of Trauma and Acute Care Surgery

Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review

(2016) Ting Zhao et al.   Frontiers in Molecular Neuroscience

Xuefu Zhuyu decoction, a traditional Chinese medicine, provides neuroprotection in a rat model of traumatic brain injury via an anti-inflammatory pathway

(2016) Zhihua Xing et al.   Scientific Reports

Long-Term Survival After Traumatic Brain Injury Part II: Life Expectancy

(2015) Jordan C. Brooks et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

(2015) Zhi Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling

(2015) Shanshan Gao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Activation of mTORC1 Signaling Worsens Neurocognitive Outcome after Traumatic Brain Injury

(2015) Natalia S. Rozas et al.   JOURNAL OF NEUROTRAUMA

Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis

(2015) Ke Ding et al.   JOURNAL OF SURGICAL RESEARCH

Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?

(2015) Guillermo Moya-Alvarado et al.   MOLECULAR & CELLULAR PROTEOMICS

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rapamycin protects neurons from brain contusion-induced inflammatory reaction via modulation of microglial activation

(2015) QI SONG et al.   Molecular Medicine Reports

Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice

(2015) Ke Ding et al.   NEUROCHEMISTRY INTERNATIONAL

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

mTOR Signaling in Epilepsy: Insights from Malformations of Cortical Development

(2015) P. B. Crino   Cold Spring Harbor Perspectives in Medicine

Rapamycin and Chloroquine: The In Vitro and In Vivo Effects of Autophagy-Modifying Drugs Show Promising Results in Valosin Containing Protein Multisystem Proteinopathy

(2015) Angèle Nalbandian et al.   PLoS One

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

(2014) Chinmoy Sarkar et al.   Autophagy

Posttraumatic administration of luteolin protects mice from traumatic brain injury: Implication of autophagy and inflammation

(2014) Jianguo Xu et al.   BRAIN RESEARCH

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD

(2014) Serena Lattante et al.   HUMAN MOLECULAR GENETICS

mTOR Signaling in T Cell Immunity and Autoimmunity

(2014) Yu Liu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Role of Akt and Mammalian Target of Rapamycin in Functional Outcome after Concussive Brain Injury in Mice

(2014) Xiaoxia Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mammalian Target of Rapamycin's Distinct Roles and Effectiveness in Promoting Compensatory Axonal Sprouting in the Injured CNS

(2014) D.-H. Lee et al.   JOURNAL OF NEUROSCIENCE

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons

(2014) Hyun-Hee Ryu et al.   NEUROBIOLOGY OF AGING

Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway

(2014) Ke Ding et al.   NEUROCHEMISTRY INTERNATIONAL

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis

(2014) S. Deivasigamani et al.   Biology Open

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Roles of Chondroitin Sulfate and Dermatan Sulfate in the Formation of a Lesion Scar and Axonal Regeneration after Traumatic Injury of the Mouse Brain

(2013) Hong-Peng Li et al.   JOURNAL OF NEUROTRAUMA

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons

(2012) Hongtao Wu et al.   BRAIN RESEARCH

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

(2012) Aruni S. Arachchige Don et al.   DRUG DISCOVERY TODAY

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

(2012) Senthil Selvaraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

(2012) L. Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?

(2012) Zhiyou Cai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp

(2012) Seung-Il Choi et al.   JOURNAL OF PINEAL RESEARCH

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options

(2011) Giuseppe Pignataro et al.   CURRENT OPINION IN PHARMACOLOGY

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology

(2011) L. Swiech et al.   JOURNAL OF NEUROSCIENCE

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

(2011) Arunabh Bhattacharya et al.   NEUROBIOLOGY OF AGING

PTEN/mTOR and axon regeneration

(2010) Kevin K. Park et al.   EXPERIMENTAL NEUROLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Acute Lung Injury Is an Independent Risk Factor for Brain Hypoxia After Severe Traumatic Brain Injury

(2010) Mauro Oddo et al.   NEUROSURGERY

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

Involvement of Akt in neurite outgrowth

(2009) Danielle E. Read et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

Neuroprotection in traumatic brain injury

(2008) K.K. Jain   DRUG DISCOVERY TODAY

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE