Flavonoids as a Natural Enhancer of Neuroplasticity—An Overview of the Mechanism of Neurorestorative Action

Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota

(2020) Jianfeng Liu et al.   Aging-US

Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies

(2020) Xiao-Wen Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of action of acute and subacute sphenopalatine ganglion stimulation for ischemic stroke

(2020) Mersedeh Bahr Hosseini et al.   International Journal of Stroke

Antidiabetic Effects of Flavan-3-ols and Their Microbial Metabolites

(2020) Estefanía Márquez Campos et al.   Nutrients

Regulation of Adult Neurogenesis in Mammalian Brain

(2020) Maria Victoria Niklison-Chirou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin as an anticancer agent: Focus on esophageal cancer

(2020) Amirhossein Davoodvandi et al.   JOURNAL OF FOOD BIOCHEMISTRY

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

(2020) Anna Kicinska et al.   MOLECULES

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

(2020) Antonio Dominguez-Meijide et al.   Scientific Reports

The Potential of Virtual Reality for Inducing Neuroplasticity in Children with Amblyopia

(2020) María B. Coco-Martin et al.   Journal of Ophthalmology

New Advances in the Determination of Free and Bound Phenolic Compounds of Banana Passion Fruit Pulp (Passiflora tripartita, var. Mollissima (Kunth) L.H. Bailey) and Their In Vitro Antioxidant and Hypoglycemic Capacities

(2020) Elisa Giambanelli et al.   Antioxidants

Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice

(2020) Jiaming Gao et al.   Aging-US

Chronic Restraint Stress Inhibits the Response to a Second Hit in Adult Male Rats: A Role for BDNF Signaling

(2020) Paola Brivio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effects of malvidin on oxidative stress parameters and inflammatory cytokines in LPS‐induced human THP‐1 cells

(2020) Alireza Bastin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cyanidin-related antidepressant-like efficacy requires PI3K/AKT/FoxG1/FGF-2 pathway modulated enhancement of neuronal differentiation and dendritic maturation

(2020) Xin Shan et al.   PHYTOMEDICINE

Neurotrophin Signaling in Medulloblastoma

(2020) Amanda Thomaz et al.   Cancers

Association Between Dietary Flavonoids Intake and Cognitive Function in an Italian Cohort

(2020) Justyna Godos et al.   Biomolecules

A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice

(2020) Yaoyao Jia et al.   Communications Biology

Network Pharmacology Integrated Molecular Docking Reveals the Antiosteosarcoma Mechanism of Biochanin A

(2019) Qing Luo et al.   Evidence-based Complementary and Alternative Medicine

(–)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway

(2019) Zhenzhen Qu et al.   MEDICAL SCIENCE MONITOR

Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer’s Disease

(2019) Danli Kong et al.   Biomed Research International

Isoflavones

(2019) Ludmila Křížová et al.   MOLECULES

Quercetin promotes learning and memory performance concomitantly with neural stem/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus

(2019) Mohammad Karimipour et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer's disease in rats

(2019) Yuping Li et al.   DRUG DEVELOPMENT RESEARCH

Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression

(2019) Arianna Di Lorenzo et al.   FOOD AND CHEMICAL TOXICOLOGY

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

(2019) Jinlin Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Equol Pretreatment Protection of SH-SY5Y Cells against Aβ (25–35)-Induced Cytotoxicity and Cell-Cycle Reentry via Sustaining Estrogen Receptor Alpha Expression

(2019) Meng-Chao Tsai et al.   Nutrients

Flavonoid-Rich Mixed Berries Maintain and Improve Cognitive Function Over a 6 h Period in Young Healthy Adults

(2019) Adrian R. Whyte et al.   Nutrients

Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway

(2018) Ling-yun Wu et al.   BEHAVIOURAL NEUROLOGY

Resveratrol Treatment in Different Time-Attenuated Neuronal Apoptosis After Oxygen and Glucose Deprivation/Reoxygenation via Enhancing the Activation of Nrf-2 Signaling Pathway In Vitro

(2018) Jun Yang et al.   CELL TRANSPLANTATION

Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway

(2018) Yu-Ling Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Harnessing neuroplasticity: modern approaches and clinical future

(2018) Andrew Octavian Sasmita et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study

(2018) Julien Bensalem et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Resveratrol loaded solid lipid nanoparticles attenuate mitochondrial oxidative stress in vascular dementia by activating Nrf2/HO-1 pathway

(2018) Aarti Yadav et al.   NEUROCHEMISTRY INTERNATIONAL

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

(2018) Jun Wang et al.   Nature Communications

Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway

(2018) Wang Nan et al.   Biomed Research International

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

(2018) Zhenhua Shi et al.   MEDICAL SCIENCE MONITOR

Activation of TrkB by 7,8-Dihydroxyflavone Prevents Fear Memory Defects and Facilitates Amygdalar Synaptic Plasticity in Aging

(2018) Yan Zeng et al.   JOURNAL OF ALZHEIMERS DISEASE

Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-κB and NLRP3 Pathways

(2018) Hong-Xin Cui et al.   MOLECULES

The effects of acute wild blueberry supplementation on the cognition of 7–10-year-old schoolchildren

(2018) Katie L. Barfoot et al.   EUROPEAN JOURNAL OF NUTRITION

Icariin Improves Functional Behavior in a Mouse Model of Traumatic Brain Injury and Promotes Synaptic Plasticity Markers

(2018) Hyejin Joo et al.   PLANTA MEDICA

Phytoestrogen isoflavone intervention to engage the neuroprotective effect of glutamate oxaloacetate transaminase against stroke

(2017) Savita Khanna et al.   FASEB JOURNAL

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway

(2017) Gerardo García-Díaz Barriga et al.   HUMAN MOLECULAR GENETICS

Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement

(2017) Nora E. Gray et al.   PHYTOCHEMISTRY REVIEWS

Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro

(2017) Lalita Subedi et al.   Nutrients

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

(2017) Hock Eng Khoo et al.   Food & Nutrition Research

Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling

(2017) Katya Zelentsova-Levytskyi et al.   Frontiers in Molecular Neuroscience

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

(2017) Flaubert Tchantchou et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

(2016) Hanaa Hibishy Gaballah et al.   CHEMICO-BIOLOGICAL INTERACTIONS

7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressingα-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease

(2016) Xiao-Huan Li et al.   CNS Neuroscience & Therapeutics

Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells

(2016) Zhen-tao Mo et al.   Evidence-based Complementary and Alternative Medicine

Induced cortical neurogenesis after focal cerebral ischemia – Three active components from Huang-Lian-Jie-Du Decoction

(2016) Haiyan Zou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Epigallocatechin-3-gallate rescues LPS-impaired adult hippocampal neurogenesis through suppressing the TLR4-NF-κB signaling pathway in mice

(2016) Kyung-Joo Seong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro

(2016) L. Ortiz-López et al.   NEUROSCIENCE

7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neurons degeneration through activation of TrkB in rodents

(2016) Dandan Luo et al.   NEUROSCIENCE LETTERS

Biochanin A Protects Against Lipopolysaccharide-Induced Damage of Dopaminergic Neurons Both In Vivo and In Vitro via Inhibition of Microglial Activation

(2016) Jun Wang et al.   NEUROTOXICITY RESEARCH

Quercetin protects the retina by reducing apoptosis due to ischemia-reperfusion injury in a rat model

(2015) Sedat Arikan et al.   ARQUIVOS BRASILEIROS DE OFTALMOLOGIA

MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson’s disease mouse

(2015) Zhao-Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans

(2015) Charlotte Regitz et al.   EUROPEAN JOURNAL OF NUTRITION

TrkB activation by 7, 8-dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease

(2015) Lei Gao et al.   JOURNAL OF NEUROCHEMISTRY

Biochanin A protects against focal cerebral ischemia/reperfusion in rats via inhibition of p38-mediated inflammatory responses

(2015) Wenbo Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The p75 neurotrophin receptor: at the crossroad of neural repair and death

(2015) RickB Meeker et al.   Neural Regeneration Research

Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study

(2015) Li Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage and oxidative stress in a rat model of Parkinson's disease

(2015) Jun Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Differential effects of quercetin on hippocampus-dependent learning and memory in mice fed with different diets related with oxidative stress

(2015) Shu-Fang Xia et al.   PHYSIOLOGY & BEHAVIOR

Enhancement of flavonoid ability to cross the blood–brain barrier of rats by co-administration with α-tocopherol

(2015) Paola Ferri et al.   Food & Function

Equol is Neuroprotective During Focal Cerebral Ischemia and Reperfusion that Involves p-Src and gp91phox

(2014) Wei Yu et al.   CURRENT NEUROVASCULAR RESEARCH

Biochanin A attenuates LPS-induced pro-inflammatory responses and inhibits the activation of the MAPK pathway in BV2 microglial cells

(2014) WANG-YANG WU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling

(2014) Feng Jin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson’s Disease

(2014) Kasthuri Bai Magalingam et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Quercetin Promotes Neuronal and Behavioral Recovery by Suppressing Inflammatory Response and Apoptosis in a Rat Model of Intracerebral Hemorrhage

(2014) Yifan Zhang et al.   NEUROCHEMICAL RESEARCH

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

(2014) Orhan Tansel Korkmaz et al.   NEUROSCIENCE LETTERS

Regulation and Function of Adult Neurogenesis: From Genes to Cognition

(2014) James B. Aimone et al.   PHYSIOLOGICAL REVIEWS

7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice

(2013) E. Bollen et al.   BEHAVIOURAL BRAIN RESEARCH

Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells

(2013) Oraphan Wanakhachornkrai et al.   BMC Complementary and Alternative Medicine

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease

(2013) M. Jiang et al.   HUMAN MOLECULAR GENETICS

DREAM/calsenilin/KChIP3 modulates strategy selection and estradiol-dependent learning and memory

(2013) T. Tunur et al.   LEARNING & MEMORY

Intrathecal Epigallocatechin Gallate Treatment Improves Functional Recovery After Spinal Cord Injury by Upregulating the Expression of BDNF and GDNF

(2013) Wei Tian et al.   NEUROCHEMICAL RESEARCH

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis

(2012) Oumei Cheng et al.   BRAIN RESEARCH

Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation

(2012) Shin Bi Oh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways

(2011) Yonggang Cao et al.   BRAIN RESEARCH BULLETIN

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats

(2011) Akari Ishisaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome

(2011) Rebecca A. Johnson et al.   JOURNAL OF APPLIED PHYSIOLOGY

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Dietary genistein and equol (4′, 7 isoflavandiol) reduce oxidative stress and protect rats against focal cerebral ischemia

(2010) Yulin Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation

(2010) Xia Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Xenobiotic Metabolism and Berry Flavonoid Transport across the Blood−Brain Barrier†

(2010) Paul E. Milbury et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

(2010) Xia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Equol: Pharmacokinetics and Biological Actions

(2010) Kenneth D. R. Setchell et al.   JOURNAL OF NUTRITION

Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson’s disease and protection by polyphenols

(2008) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

(2008) Claire M. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estradiol treatment and its interaction with the cholinergic system: Effects on cognitive function in healthy young women

(2008) C BARTHOLOMEUSZ et al.   HORMONES AND BEHAVIOR

Effects of icariin combined withPanax notoginseng saponins on ischemia reperfusion-induced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat

(2008) Ming Zheng et al.   PHYTOTHERAPY RESEARCH