Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease

The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism

(2017) D Masini et al.   Translational Psychiatry

mTORC1–S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice

(2016) Jiandong Sun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkinson’s Disease and Cognitive Impairment

(2016) Yang Yang et al.   Parkinsons Disease

Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents

(2015) Ben Grayson et al.   BEHAVIOURAL BRAIN RESEARCH

Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome

(2015) Yuniesky Andrade-Talavera et al.   NEUROBIOLOGY OF DISEASE

Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

(2015) Aditi Bhattacharya et al.   NEUROPSYCHOPHARMACOLOGY

A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions

(2014) Alessandra Bonito-Oliva et al.   Frontiers in Behavioral Neuroscience

Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism

(2013) Alessandra Bonito-Oliva et al.   BIOLOGICAL PSYCHIATRY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

A proposal for refining the forced swim test in Swiss mice

(2013) Ana Paula Ramos Costa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment

(2012) Per Svenningsson et al.   LANCET NEUROLOGY

From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches

(2012) Dan Ehninger   NEUROPHARMACOLOGY

Deregulated mTOR-mediated translation in intellectual disability

(2012) José Antonio Troca-Marín et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway

(2012) Jing-Jie Yu et al.   PSYCHOPHARMACOLOGY

Treatment of depressive symptoms in Parkinson’s disease

(2011) P. Barone   EUROPEAN JOURNAL OF NEUROLOGY

An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome

(2011) J. A. Troca-Marin et al.   JOURNAL OF NEUROSCIENCE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Neurodegeneration and Inflammation in Parkinson's disease

(2011) Sudarshan Phani et al.   PARKINSONISM & RELATED DISORDERS

Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex

(2011) Kristy R. Howell et al.   PLoS One

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

(2010) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Neurotransmission in Parkinson’s disease: beyond dopamine

(2009) P. Barone   EUROPEAN JOURNAL OF NEUROLOGY

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Immunosuppression Using the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus: Pilot Study Shows Significant Cognitive and Affective Improvement

(2009) U.E. Lang et al.   TRANSPLANTATION PROCEEDINGS

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

(2008) J. A. Ronesi et al.   JOURNAL OF NEUROSCIENCE

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE