Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice

Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression

(2021) Can Yan et al.   Neural Regeneration Research

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies

(2020) Jonathan Chang-Cheng Shieh et al.   MOLECULAR NEUROBIOLOGY

Icariin treatment reduces blood glucose levels in type�2 diabetic rats and protects pancreatic function

(2020) Xin Li et al.   Experimental and Therapeutic Medicine

Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease

(2020) Thuy Trang Nguyen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin mediated novel therapies for the treatment of Alzheimer's disease

(2020) Sunil Kumar Dubey et al.   LIFE SCIENCES

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

(2020) Antonella Tramutola et al.   NEUROBIOLOGY OF DISEASE

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

(2020) Ansab Akhtar et al.   NEUROCHEMISTRY INTERNATIONAL

Glucose transporters in brain in health and disease

(2020) Hermann Koepsell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Insulin resistance: a connecting link between Alzheimer’s disease and metabolic disorder

(2020) Viplav Kshirsagar et al.   METABOLIC BRAIN DISEASE

Alzheimer amyloid β-peptide disrupts membrane localization of glucose transporter 1 in astrocytes: Implications for glucose levels in brain and blood

(2020) Rachel D. Hendrix et al.   NEUROBIOLOGY OF AGING

Quantitative Measurement of Cerebrospinal Fluid Amyloid-β Species by Mass Spectrometry

(2020) Yusuke Seino et al.   JOURNAL OF ALZHEIMERS DISEASE

Icariin and Its Metabolites as Potential Protective Phytochemicals Against Alzheimer’s Disease

(2019) Cristina Angeloni et al.   Frontiers in Pharmacology

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation

(2019) Rudy J. Castellani et al.   LABORATORY INVESTIGATION

Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover

(2019) Shanshan Qi et al.   MOLECULES

Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway

(2019) Nanqu Huang et al.   EXPERIMENTAL GERONTOLOGY

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

(2019) Chaitanya Chakravarthi Gali et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress

(2019) Fei Li et al.   LIFE SCIENCES

Angelica polysaccharide ameliorates memory impairment in Alzheimer’s disease rat through activating BDNF/TrkB/CREB pathway

(2019) Qian Du et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models

(2019) Hang Wu et al.   LIFE SCIENCES

The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease

(2019) Bhumsoo Kim et al.   NEUROBIOLOGY OF DISEASE

Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis

(2019) Panwen Liu et al.   PHYSIOLOGY & BEHAVIOR

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link

(2018) Ying Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

PSD95: A synaptic protein implicated in schizophrenia or autism?

(2018) Austin A. Coley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

(2018) Taeko Kimura et al.   Frontiers in Neuroscience

3xTg-AD Mice Exhibit an Activated Central Stress Axis During Early-Stage Pathology

(2018) Elaine K. Hebda-Bauer et al.   JOURNAL OF ALZHEIMERS DISEASE

Impaired Neuronal Insulin Signaling Precedes Aβ42 Accumulation in Female AβPPsw/PS1ΔE9 Mice

(2018) Li-Min Chua et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease

(2018) Richard Hodson   NATURE

An outline for the pharmacological effect of icariin in the nervous system

(2018) Jie Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Diabetes and Alzheimer’s Disease: A Link not as Simple as it Seems

(2018) Isabel H. Salas et al.   NEUROCHEMICAL RESEARCH

Molecular Mechanisms of the Memory Trace

(2018) Arun Asok et al.   TRENDS IN NEUROSCIENCES

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insulin action in the brain: Roles in energy and glucose homeostasis

(2017) G. T. Dodd et al.   JOURNAL OF NEUROENDOCRINOLOGY

Icariin, a major constituent from Epimedium brevicornum , attenuates ibotenic acid-induced excitotoxicity in rat hippocampus

(2016) Nan Zong et al.   BEHAVIOURAL BRAIN RESEARCH

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

(2016) Teresa Niccoli et al.   CURRENT BIOLOGY

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization

(2015) Alexey Potapov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice

(2015) F. Li et al.   NEUROSCIENCE

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling

(2014) Feng Jin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Mechanisms of Neuroprotection from Hypoxia-Ischemia (HI) Brain Injury by Up-regulation of Cytoglobin (CYGB) in a Neonatal Rat Model

(2013) Shu-Feng Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen associated gene polymorphisms and their interactions in the progress of Alzheimer's disease

(2013) Y. Xing et al.   PROGRESS IN NEUROBIOLOGY

Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience

(2012) Orwa Aboud et al.   BMC Medicine

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils?

(2011) Jeremy D. Schmit et al.   BIOPHYSICAL JOURNAL

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL