Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells

Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation

(2020) Rita Marreiros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

(2019) A. Raquel Esteves et al.   MOLECULAR NEUROBIOLOGY

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification

(2019) Mümine Şentürk et al.   NATURE CELL BIOLOGY

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

(2019) Zhou Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies

(2019) Przemyslaw Solek et al.   APOPTOSIS

Impaired autophagy promotes bile acid-induced hepatic injury and accumulation of ubiquitinated proteins

(2018) Soojin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein aggregates and proteostasis in aging: Amylin and β-cell function

(2018) Michaela Press et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mechanisms of lysosomal positioning and movement

(2018) Birol Cabukusta et al.   TRAFFIC

Abnormal hippocampal neurogenesis in Parkinson’s disease: relevance to a new therapeutic target for depression with Parkinson’s disease

(2018) Juhee Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Tricyclic antidepressant amitriptyline inhibits autophagic flux and prevents tube formation in vascular endothelial cells

(2018) Yinglu Guan et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain aging and neurodegeneration: from a mitochondrial point of view

(2017) Amandine Grimm et al.   JOURNAL OF NEUROCHEMISTRY

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

(2017) Wei Wan et al.   MOLECULAR CELL

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Augmenting brain metabolism to increase macro- and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging

(2017) Ben Loos et al.   PROGRESS IN NEUROBIOLOGY

Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72

(2017) Mauricio Budini et al.   Frontiers in Molecular Neuroscience

The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance

(2017) Paolo Remondelli et al.   Frontiers in Molecular Neuroscience

Assays to Monitor Autophagy Progression in Cell Cultures

(2017) Idil Orhon et al.   Cells

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

(2016) Kazue Hisaoka-Nakashima et al.   BRAIN RESEARCH

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Imipramine and amitriptyline ameliorate the rotenone model of Parkinson’s disease in rats

(2016) Esraa A. Kandil et al.   NEUROSCIENCE

Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?

(2015) Rosa Gonzalez-Polo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson’s Disease

(2015) Min-yeong Lee et al.   MOLECULES AND CELLS

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

(2015) Ting Sun et al.   Nature Communications

Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation

(2015) Jihong Chen et al.   Scientific Reports

Depressive symptoms in neurodegenerative diseases

(2015) Miquel Baquero   World Journal of Clinical Cases

Protein Folding, Misfolding, Aggregation and Their Implications in Human Diseases: Discovering Therapeutic Ways to Amyloid-Associated Diseases

(2014) Afshin Iram et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Accumulation of modified proteins and aggregate formation in aging

(2014) Kerstin Nowotny et al.   EXPERIMENTAL GERONTOLOGY

Preconditioning stimulus of proteasome inhibitor enhances aggresome formation and autophagy in differentiated SH-SY5Y cells

(2014) Yeojin Bang et al.   NEUROSCIENCE LETTERS

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Drug-induced parkinsonism

(2013) José López-Sendón et al.   Expert Opinion On Drug Safety

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line

(2013) Lorna A. Farrelly et al.   REGULATORY PEPTIDES

Drug-Induced Parkinsonism

(2012) Hae-Won Shin et al.   Journal of Clinical Neurology

Prevalence of major depression in ALS: Comparison of a semi-structured interview and four self-report measures

(2011) Panagiotis Ferentinos et al.   Amyotrophic Lateral Sclerosis

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

(2011) D. P. Cina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

(2011) Wayne Chadwick et al.   PLoS One

Subtypes of depression among patients with Alzheimer's disease and other dementias

(2010) Ruby C. Castilla-Puentes et al.   Alzheimers & Dementia

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy research: Lessons from metabolism

(2009) Alfred J. Meijer   Autophagy

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Chaperones in control of protein disaggregation

(2008) Krzysztof Liberek et al.   EMBO JOURNAL