Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

(2019) Bei Zhang et al.   Frontiers in Cellular Neuroscience

Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling

(2018) Jia Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation in Vivo and in Vitro

(2018) Guo-Qing Wang et al.   Frontiers in Molecular Neuroscience

Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation

(2018) Yuguang Zhao et al.   Redox Biology

Hydroxysafflor Yellow A Improves Motor Dysfunction in the Rotenone-Induced Mice Model of Parkinson’s Disease

(2017) Tian Wang et al.   NEUROCHEMICAL RESEARCH

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation

(2016) Yao-Hong Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

(2016) Noemie Tentillier et al.   JOURNAL OF NEUROSCIENCE

The Keap1/Nrf2 pathway in health and disease: from the bench to the clinic

(2015) Maria A. O’Connell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injuryin vitroandin vivo

(2015) Huanying Shi et al.   JOURNAL OF NEUROCHEMISTRY

Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease

(2015) N. Panicker et al.   JOURNAL OF NEUROSCIENCE

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

Neurotrauma and Inflammation: CNS and PNS Responses

(2015) Bruno Siqueira Mietto et al.   MEDIATORS OF INFLAMMATION

Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation

(2015) B. Liu et al.   NEUROSCIENCE

Shiga toxin-2 enhances heat-shock-induced apoptotic cell death in cultured and primary glial cells

(2014) Naotoshi Sugimoto et al.   CELL BIOLOGY AND TOXICOLOGY

Application of a Solar UV/Chlorine Advanced Oxidation Process to Oil Sands Process-Affected Water Remediation

(2014) Zengquan Shu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes

(2014) Pratap Karki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Pathogenesis-Targeted, Disease-Modifying Therapies in Parkinson Disease

(2013) Amaal AlDakheel et al.   Neurotherapeutics

Cancer pain is not necessarily correlated with spinal overexpression of reactive glia markers

(2013) Vincent R.R. Ducourneau et al.   PAIN

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease

(2011) Calivarathan Latchoumycandane et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of I B Kinase-  Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity

(2010) F. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY