α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain

Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours

(2023) Alice Courties et al.   ANNALS OF THE RHEUMATIC DISEASES

Selective Agonists and Antagonists of α9 Versus α7 Nicotinic Acetylcholine Receptors

(2022) Roger L. Papke et al.   ACS Chemical Neuroscience

Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells

(2022) Yuichiro Nakata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Cholinergic Anti-Inflammatory Pathway in Protecting Sepsis-Induced Acute Lung Injury through Regulation of the Conventional Dendritic Cells

(2022) Ruiting Li et al.   MEDIATORS OF INFLAMMATION

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor

(2022) Vasyl Bondarenko et al.   Nature Communications

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications

(2022) Igor Kasheverov et al.   Biomolecules

α-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy

(2022) I.A. Dyachenko et al.   BIOCHIMIE

The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders

(2022) Simona Di Lascio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages

(2022) Yao Tan et al.   Marine Drugs

Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP

(2022) Katrin Richter et al.   Frontiers in Cellular Neuroscience

The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial Clearance via Regulation of Monocyte Recruitment and Activity in Polymicrobial Septic Peritonitis

(2022) Jian-nan Hu et al.   Frontiers in Immunology

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis

(2022) Alice Courties et al.   Frontiers in Immunology

Oligo-basic amino acids, potential nicotinic acetylcholine receptor inhibitors

(2022) Baojian Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Preparation of uniform-sized GeXIVA[1,2]-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency

(2022) Lu Li et al.   DRUG DELIVERY

From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue

(2022) Francesco Bavo et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor

(2022) Juan Facundo Chrestia et al.   MOLECULAR NEUROBIOLOGY

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors

(2022) Mieke Nys et al.   Nature Communications

Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research

(2022) Neal L Benowitz et al.   Lancet Respiratory Medicine

Activation of Cholinergic Anti-Inflammatory Pathway Ameliorates Cerebral and Cardiac Dysfunction After Intracerebral Hemorrhage Through Autophagy

(2022) Yue Su et al.   Frontiers in Immunology

Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody

(2022) Heather M. Callaway et al.   Science Advances

Discovery and Structural and Functional Characterization of a Novel A-Superfamily Conotoxin Targeting α9α10 Nicotinic Acetylcholine Receptor

(2022) Qiuyuan Huang et al.   ACS Chemical Biology

Immunization with 674–685 fragment of SARS-Cov-2 spike protein induces neuroinflammation and impairs episodic memory of mice

(2022) Olena Lykhmus et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The emergence of the uniquely human α7 nicotinic acetylcholine receptor gene and its roles in inflammation

(2022) Wanling Peng et al.   GENE

An experimental test of the nicotinic hypothesis of COVID-19

(2022) Nicole E. Godellas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting α7 nicotinic acetylcholine receptors for chronic pain

(2022) Ya-Qun Zhou et al.   Frontiers in Molecular Neuroscience

Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

(2022) Xiaoyu Zhu et al.   Pharmaceutics

Up‐regulation of the human‐specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy

(2022) Bingru Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism

(2022) Francesco Margiotta et al.   Marine Drugs

RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires α9-Containing Nicotinic Acetylcholine Receptors and CD3+ T-Cells

(2022) Peter N. Huynh et al.   Cells

Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors

(2022) Zakhar O. Shenkarev et al.   Communications Biology

Nicotinic Cholinergic System and COVID-19: In Silico Identification of Interactions Βetween α7 Nicotinic Acetylcholine Receptor and the Cryptic Epitopes of SARS-Co-V and SARS-CoV-2 Spike Glycoproteins

(2021) George Lagoumintzis et al.   FOOD AND CHEMICAL TOXICOLOGY

A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors

(2021) A. Sofia F. Oliveira et al.   BIOPHYSICAL JOURNAL

Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]

(2021) Zhiguo Li et al.   Marine Drugs

Street RABV Induces the Cholinergic Anti-inflammatory Pathway in Human Monocyte-Derived Macrophages by Binding to nAChr α7

(2021) Carmen W. E. Embregts et al.   Frontiers in Immunology

Regulatory Dendritic Cells, T Cell Tolerance, and Dendritic Cell Therapy for Immunologic Disease

(2021) Sara Ness et al.   Frontiers in Immunology

Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120JRFL

(2021) Sonnieliz Cotto Ríos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human α7 Nicotinic Acetylcholine Receptors

(2021) Shuai Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Pathways for the Skin's Stress Response: The Cholinergic Neuropeptide SLURP-1 Can Activate Mast Cells and Alter Cytokine Production in Mice

(2021) Christoph M. Ertle et al.   Frontiers in Immunology

Globular and ribbon isomers of Conus geographus α-conotoxins antagonize human nicotinic acetylcholine receptors

(2021) Han-Shen Tae et al.   BIOCHEMICAL PHARMACOLOGY

Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology

(2021) Xiaojie Zhao et al.   BRAIN

Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism

(2021) Joanna Gajewiak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain

(2021) Nan Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors

(2021) Roger L. Papke et al.   PHARMACOLOGICAL REVIEWS

ɑO‐Conotoxin GeXIVA isomers modulate N‐type calcium (Ca V 2.2) channels and inwardly‐rectifying potassium (GIRK) channels via GABA B receptor activation

(2021) Arsalan Yousuf et al.   JOURNAL OF NEUROCHEMISTRY

Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort

(2021) Ashley K Clift et al.   THORAX

COVID-19 and Smoking. Is Nicotine the Hidden Link?

(2020) Patrizia Russo et al.   EUROPEAN RESPIRATORY JOURNAL

Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option?

(2020) Konstantinos Farsalinos et al.   Internal and Emergency Medicine

Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells

(2020) Mikhail A. Shulepko et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

α7 nAChRs expressed on antigen presenting cells are insensitive to the conventional antagonists α-bungarotoxin and methyllycaconitine

(2020) Masato Mashimo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Water‐soluble variant of human Lynx1 positively modulates synaptic plasticity and ameliorates cognitive impairment associated with α7‐nAChR dysfunction

(2020) Zakhar O. Shenkarev et al.   JOURNAL OF NEUROCHEMISTRY

Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins

(2020) Md. Mahfuzur Rahman et al.   NEURON

Chemotherapy-induced peripheral neuropathy—part 2: focus on the prevention of oxaliplatin-induced neurotoxicity

(2020) Kinga Sałat   Pharmacological Reports

Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19

(2020) Marat Fudim et al.   Journal of Cardiovascular Translational Research

Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression

(2020) Andrei E. Siniavin et al.   Biomolecules

How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?

(2020) Malgorzata Kloc et al.   IMMUNOLOGY LETTERS

Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications

(2020) Konstantinos Farsalinos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three‐finger proteins from snakes and humans acting on nicotinic receptors: Old and new

(2020) Victor I. Tsetlin et al.   JOURNAL OF NEUROCHEMISTRY

Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors

(2020) Alexander S. Paramonov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists

(2020) M. Allahverdi Khani et al.   MEDICAL HYPOTHESES

α9α10 nicotinic acetylcholine receptors regulate murine bone marrow granulocyte functions

(2020) Valentina G. Safronova et al.   IMMUNOBIOLOGY

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

(2020) Thao N. T. Ho et al.   Frontiers in Neuroscience

Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis

(2020) Ildernandes Vieira-Alves et al.   Frontiers in Physiology

Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models

(2020) Konstantin S. Mineev et al.   Biomolecules

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor

(2020) Xiao Li et al.   PHARMACOLOGY & THERAPEUTICS

Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes

(2019) Veronika Grau et al.   Frontiers in Pharmacology

Association of a functional polymorphism in the CHRFAM7A gene with inflammatory response mediators and neuropathic pain after spinal cord injury

(2019) Wan Huang et al.   JOURNAL OF NEUROTRAUMA

The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain

(2019) Huanbai Wang et al.   Marine Drugs

The secreted Ly6/uPAR-related protein-1 suppresses neutrophil binding, chemotaxis, and transmigration through human umbilical vein endothelial cells

(2019) Sudha Swamynathan et al.   Scientific Reports

Lynx Prototoxins: Roles of Endogenous Mammalian Neurotoxin-Like Proteins in Modulating Nicotinic Acetylcholine Receptor Function to Influence Complex Biological Processes

(2019) Julie M. Miwa et al.   Frontiers in Pharmacology

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors

(2019) Marios Zouridakis et al.   Frontiers in Pharmacology

Acetylcholine-producing T-cells augment innate immune driven colitis but are redundant in T-cell driven colitis

(2019) Rose A Willemze et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway

(2019) Annalisa Maroli et al.   JOURNAL OF NEUROIMMUNOLOGY

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

(2019) Elena V. Kryukova et al.   Frontiers in Pharmacology

Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells

(2019) Geeta Upadhyay   Frontiers in Immunology

Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation

(2019) Masato Mashimo et al.   Frontiers in Immunology

α-Conotoxin Vc1.1 Structure–Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement

(2019) Xin Chu et al.   ACS Chemical Neuroscience

Oligoarginine Peptides, a New Family of nAChR Inhibitors

(2019) Dmitry Lebedev et al.   MOLECULAR PHARMACOLOGY

The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-α-induced cytokine production

(2019) Gregory Campbell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating α7-nicotinic acetylcholine receptors/ERK- EMT

(2019) Xuefeng Bu et al.   BMC CANCER

Conotoxins: Chemistry and Biology

(2019) Ai-Hua Jin et al.   CHEMICAL REVIEWS

RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats

(2019) Peter N. Huynh et al.   Marine Drugs

Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors

(2018) E N Lyukmanova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source

(2018) Jiacheng Ma et al.   CANCER

Nicotinic Acetylcholine Receptors in HIV: Possible Roles During HAND and Inflammation

(2018) Coral M. Capó-Vélez et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Cholinergic Anti-Inflammatory Response and the Role of Macrophages in HIV-Induced Inflammation

(2018) Manuel Delgado-Vélez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α7 nicotinic acetylcholine receptors are involved in suppression of the antibody immune response

(2018) Lyudmyla Koval et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails

(2018) Nikita Abraham et al.   Marine Drugs

Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists

(2018) Jinpeng Yu et al.   NEUROPHARMACOLOGY

OUP accepted manuscript

(2018)   PAIN MEDICINE

Augmenting the antinociceptive effects of nicotinic acetylcholine receptor activity through lynx1 modulation

(2018) Neel I. Nissen et al.   PLoS One

Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors

(2018) Nadine Kabbani et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer

(2018) Verena M. Throm et al.   Oncotarget

Synthesis, Structure and Biological Activity of CIA and CIB, Two α-Conotoxins from the Predation-Evoked Venom of Conus catus

(2018) Julien Giribaldi et al.   Toxins

The antinociceptive and anti-inflammatory properties of the α7 nAChR weak partial agonistp-CF3N,N-diethyl-N’-phenylpiperazine

(2018) Marta Quadri et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells

(2018) Katrin Richter et al.   MOLECULES

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation

(2018) Katrin Richter et al.   Frontiers in Immunology

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex

(2018) Laura Tarnawski et al.   Frontiers in Immunology

Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors

(2017) Sören Backhaus et al.   JOURNAL OF LIPID RESEARCH

Physiological functions of the cholinergic system in immune cells

(2017) Takeshi Fujii et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor

(2017) Shantong Jiang et al.   Marine Drugs

Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28.1 with previously undescribed cysteine pattern

(2017) Jianbo Lu et al.   PEPTIDES

Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages

(2017) Wei Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

(2017) Haylie K. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

(2017) Sean B. Christensen et al.   Frontiers in Cellular Neuroscience

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10

(2017) Anna Zakrzewicz et al.   Frontiers in Cellular Neuroscience

Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

(2017) Thomas Durek et al.   Scientific Reports

Expression and Function of the Cholinergic System in Immune Cells

(2017) Takeshi Fujii et al.   Frontiers in Immunology

Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS

(2017) Karsten Hueffer et al.   Scientific Reports

Effects of α-conotoxin ImI on TNF-α, IL-8 and TGF-β expression by human macrophage-like cells derived from THP-1 pre-monocytic leukemic cells

(2017) Alberto Padilla et al.   Scientific Reports

Acetylcholine polarizes dendritic cells toward a Th2-promoting profile

(2016) S. Gori et al.   ALLERGY

Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif

(2016) Bodil B. Carstens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

Nicotinic receptor involvement in regulation of functions of mouse neutrophils from inflammatory site

(2016) Valentina G. Safronova et al.   IMMUNOBIOLOGY

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells

(2016) Samanta R. Zanetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infiltration of CCR2+Ly6ChighProinflammatory Monocytes and Neutrophils into the Central Nervous System Is Modulated by Nicotinic Acetylcholine Receptors in a Model of Multiple Sclerosis

(2016) Wei Jiang et al.   JOURNAL OF IMMUNOLOGY

Nicotine induces neutrophil extracellular traps

(2016) Ava Hosseinzadeh et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms

(2016) Gabriella MacDougall et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

(2016) Bo Lin et al.   Marine Drugs

Nicotinic Acetylcholine Receptors Modulate Bone Marrow-Derived Pro-Inflammatory Monocyte Production and Survival

(2016) Stéphanie St-Pierre et al.   PLoS One

Anti-hypersensitive effect of intramuscular administration of αO-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic pain

(2016) Xiaodan Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method

(2016) Igor E. Kasheverov et al.   Scientific Reports

Phosphocholine – an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors

(2016) K. Richter et al.   Scientific Reports

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor

(2016) Ekaterina N. Lyukmanova et al.   PLoS One

αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors

(2015) Sean B. Christensen et al.   BIOCHEMICAL PHARMACOLOGY

Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the a7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells

(2015) Yong-Hua Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs

(2015) Koichiro Kawashima et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

(2015) Andreas Hecker et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

(2015) Shuo Wang et al.   Marine Drugs

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

(2015) Sulan Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotine Exposure Alters the mRNA Expression of Notch Ligands in Dendritic Cells and Their Response to Th1-/Th2-Promoting Stimuli

(2015) M. Nouri-Shirazi et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators

(2015) Victor I. Tsetlin   TRENDS IN PHARMACOLOGICAL SCIENCES

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

(2015) Sarasa Mohammadi et al.   Toxins

Functional expression and axonal transport of α7 nAChRs by peptidergic nociceptors of rat dorsal root ganglion

(2014) Irina Shelukhina et al.   Brain Structure & Function

Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

(2014) Kalyana B. Akondi et al.   CHEMICAL REVIEWS

Structure-Function Elucidation of a New α-Conotoxin, Lo1a, fromConus longurionis

(2014) Eline K. M. Lebbe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

(2014) Eline Lebbe et al.   Marine Drugs

α9-Nicotinic Acetylcholine Receptors Contribute to the Maintenance of Chronic Mechanical Hyperalgesia, but Not Thermal or Mechanical Allodynia

(2014) Sarasa Mohammadi et al.   Molecular Pain

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

(2014) Lorenzo Di Cesare Mannelli et al.   PAIN

Discovery of a new subclass of α-conotoxins in the venom of Conus australis

(2014) Eline K.M. Lebbe et al.   TOXICON

Isolation, purification and functional characterization of alpha-BnIA from Conus bandanus venom

(2014) Bao Nguyen et al.   TOXICON

Anti-Inflammatory Effects of the Nicotinergic Peptides SLURP-1 and SLURP-2 on Human Intestinal Epithelial Cells and Immunocytes

(2014) Alex I. Chernyavsky et al.   Biomed Research International

Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

(2013) Bianca J. van Lierop et al.   ACS Chemical Biology

Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors

(2013) Marco C. Inserra et al.   BIOCHEMICAL PHARMACOLOGY

MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors

(2013) Ai-Hua Jin et al.   BIOCHEMISTRY

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

(2013) Rilei Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity

(2013) Takeshi Fujii et al.   JOURNAL OF NEUROIMMUNOLOGY

Nicotinic Receptor β2 Determines NK Cell-Dependent Metastasis in a Murine Model of Metastatic Lung Cancer

(2013) Junwei Hao et al.   PLoS One

Lymphocyte-derived ACh regulates local innate but not adaptive immunity

(2013) Colin Reardon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins

(2012) Hartmut Cuny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinic Acetylcholine Receptor Expression and Susceptibility to Cholinergic Immunomodulation in Human Monocytes of Smoking Individuals

(2012) Esmerij P. van der Zanden et al.   NEUROIMMUNOMODULATION

Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain

(2012) I.A. Napier et al.   NEUROPHARMACOLOGY

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

(2011) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

RegIIA: An α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs

(2011) Aldo Franco et al.   BIOCHEMICAL PHARMACOLOGY

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic

(2011) Joseph R. Holtman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The cholinergic system in guttate psoriasis with special reference to mast cells

(2011) Julia Radosa et al.   EXPERIMENTAL DERMATOLOGY

NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1

(2011) Ekaterina N. Lyukmanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Embryonic Toxin Expression in the Cone SnailConus victoriae

(2011) Helena Safavi-Hemami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Activity of α-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABABReceptor-coupled N-type Calcium Channels

(2011) Norelle L. Daly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α7-Cholinergic Receptor Mediates Vagal Induction of Splenic Norepinephrine

(2011) Gergely Vida et al.   JOURNAL OF IMMUNOLOGY

Assembly of nicotinic and other Cys-loop receptors

(2011) Victor Tsetlin et al.   JOURNAL OF NEUROCHEMISTRY

Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

(2011) Igor E. Kasheverov et al.   Marine Drugs

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice

(2010) Brid Callaghan et al.   Channels

Function of Partially Duplicated Human α7 Nicotinic Receptor SubunitCHRFAM7AGene

(2010) Ana M. de Lucas-Cerrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotine Inhibits Fc RI-Induced Cysteinyl Leukotrienes and Cytokine Production without Affecting Mast Cell Degranulation Through  7/ 9/ 10-Nicotinic Receptors

(2010) N. C. Mishra et al.   JOURNAL OF IMMUNOLOGY

Stimulation of  7 Nicotinic Acetylcholine Receptor by Nicotine Increases Suppressive Capacity of Naturally Occurring CD4+CD25+ Regulatory T Cells in Mice In Vitro

(2010) D.-w. Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily

(2010) Knut Adermann et al.   PROTEIN SCIENCE

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

Auto/paracrine control of inflammatory cytokines by acetylcholine in macrophage-like U937 cells through nicotinic receptors

(2009) Alexander I. Chernyavsky et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Synthetic Combinatorial Strategy for Developing α-Conotoxin Analogs as Potent α7Nicotinic Acetylcholine Receptor Antagonists

(2009) Christopher J. Armishaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses

(2009) E. Nizri et al.   JOURNAL OF IMMUNOLOGY

Requisite Role of the Cholinergic α7 Nicotinic Acetylcholine Receptor Pathway in Suppressing Gram-Negative Sepsis-Induced Acute Lung Inflammatory Injury

(2009) Xiao Su et al.   JOURNAL OF IMMUNOLOGY

Nicotine-mediated signals modulate cell death and survival of T lymphocytes

(2009) Silvia C.S. Oloris et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors

(2008) Natsuko Kageyama-Yahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Synthesis and Characterization of 125I- -Conotoxin ArIB[V11L;V16A], a Selective  7 Nicotinic Acetylcholine Receptor Antagonist

(2008) P. Whiteaker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

 Conotoxin Arenatus IB[V11L,V16D] Is a Potent and Selective Antagonist at Rat and Human Native  7 Nicotinic Acetylcholine Receptors

(2008) N. Innocent et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA