Oligo-basic amino acids, potential nicotinic acetylcholine receptor inhibitors

Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain

(2021) Nan Zheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas

(2021) Jose A. Matta et al.   SCIENCE

Glutaraldehyde Cross-Linking of Oligolysines Coating DNA Origami Greatly Reduces Susceptibility to Nuclease Degradation

(2020) Frances M. Anastassacos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA

(2020) Zhihua Sun et al.   Marine Drugs

αO-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with α9 Nicotine Acetylcholine Receptors

(2020) Zhihua Sun et al.   Marine Drugs

Brain control of humoral immune responses amenable to behavioural modulation

(2020) Xu Zhang et al.   NATURE

Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor

(2020) Jean-Pierre Changeux   Biomolecules

Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products

(2020) Shenyan Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunable multiphase dynamics of arginine and lysine liquid condensates

(2020) Rachel S. Fisher et al.   Nature Communications

Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

(2020) Susanna Pucci et al.   PHARMACOLOGICAL RESEARCH

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor

(2020) Xiao Li et al.   PHARMACOLOGY & THERAPEUTICS

Polyarginine Peptides As a New Class of Ligands of Nicotinic Acetylcholine Receptors

(2019) E. V. Kryukova et al.   Doklady Biochemistry and Biophysics

d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

(2019) Jie Ren et al.   Marine Drugs

Oligoarginine Peptides, a New Family of nAChR Inhibitors

(2019) Dmitry Lebedev et al.   MOLECULAR PHARMACOLOGY

A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose

(2019) Yan Liu et al.   NANO LETTERS

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling

(2018) Heejin Jun et al.   NATURE MEDICINE

Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan

(2018) Francesco Bavo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

(2018) Christoph Allolio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly disordered histone H1−DNA model complexes and their condensates

(2018) Abigail L. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms

(2017) Sébastien Dutertre et al.   NEUROPHARMACOLOGY

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

Systematic Comparisons of Formulations of Linear Oligolysine Peptides with siRNA and Plasmid DNA

(2016) Albert Kwok et al.   Chemical Biology & Drug Design

A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis

(2016) Lin Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease

(2016) Valentina Echeverria et al.   PROGRESS IN NEUROBIOLOGY

Role of α7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells

(2016) Chun Zhang et al.   Oncotarget

The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer

(2015) Dong Mei et al.   BIOMATERIALS

Diversity of native nicotinic receptor subtypes in mammalian brain

(2015) Michele Zoli et al.   NEUROPHARMACOLOGY

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

(2015) Sulan Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cleavable PEGylation and Hydrophobic Histidylation of Polylysine for siRNA Delivery and Tumor Gene Therapy

(2014) Haiyan Zhu et al.   ACS Applied Materials & Interfaces

Cationic Poly-l-lysine Dendrimer Complexes Doxorubicin and Delays Tumor Growth in Vitro and in Vivo

(2013) Khuloud T. Al-Jamal et al.   ACS Nano

A Universal Protein Tag for Delivery of SiRNA-Aptamer Chimeras

(2013) Hong Yan Liu et al.   Scientific Reports

Poly-l-lysine Functionalized Large Pore Cubic Mesostructured Silica Nanoparticles as Biocompatible Carriers for Gene Delivery

(2012) Sandy B. Hartono et al.   ACS Nano

Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

(2012) Hisaaki Hirose et al.   MOLECULAR THERAPY

Nicotinic Acetylcholine Receptor-Based Blockade: Applications of Molecular Targets for Cancer Therapy

(2011) C.-H. Wu et al.   CLINICAL CANCER RESEARCH

The efferent medial olivocochlear-hair cell synapse

(2011) Ana Belén Elgoyhen et al.   JOURNAL OF PHYSIOLOGY-PARIS

Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy

(2011) Robert H. Mo et al.   MOLECULAR PHARMACEUTICS

Functional Characterization of  9-Containing Cholinergic Nicotinic Receptors in the Rat Adrenal Medulla: Implication in Stress-Induced Functional Plasticity

(2010) C. Colomer et al.   JOURNAL OF NEUROSCIENCE

Overexpression and Activation of the α9-Nicotinic Receptor During Tumorigenesis in Human Breast Epithelial Cells

(2010) Chia-Hwa Lee et al.   JNCI-Journal of the National Cancer Institute

Nicotine addiction and nicotinic receptors: lessons from genetically modified mice

(2010) Jean-Pierre Changeux   NATURE REVIEWS NEUROSCIENCE

Inhibition of Nonneuronal α7-Nicotinic Receptor for Lung Cancer Treatment

(2009) Laura Paleari et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis

(2008) Richard D. Egleton et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY