Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

Dicarba Analogues of α-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets

(2014) Sandeep Chhabra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

(2014) Eline Lebbe et al.   Marine Drugs

α9-Nicotinic Acetylcholine Receptors Contribute to the Maintenance of Chronic Mechanical Hyperalgesia, but Not Thermal or Mechanical Allodynia

(2014) Sarasa Mohammadi et al.   Molecular Pain

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

(2014) Lorenzo Di Cesare Mannelli et al.   PAIN

Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

(2013) Bianca J. van Lierop et al.   ACS Chemical Biology

Neuronal nicotinic receptors as analgesic targets: It's a winding road

(2013) Iboro C. Umana et al.   BIOCHEMICAL PHARMACOLOGY

MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors

(2013) Ai-Hua Jin et al.   BIOCHEMISTRY

Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels

(2013) David J. Adams et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Two Distinct Channels Mediated by m2mAChR and α9nAChR Co-Exist in Type II Vestibular Hair Cells of Guinea Pig

(2013) Tao Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors

(2013) Anton A. Grishin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Small Molecule α9α10 Nicotinic Receptor Antagonist Prevents and Reverses Chemotherapy-Evoked Neuropathic Pain in Rats

(2012) Elzbieta P. Wala et al.   ANESTHESIA AND ANALGESIA

The role of TRPA1 in visceral inflammation and pain

(2012) Tamia K. Lapointe et al.   Channels

Therapeutic Potential of Cone Snail Venom Peptides (Conopeptides)

(2012) Irina Vetter et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

The Economic Costs of Pain in the United States

(2012) Darrell J. Gaskin et al.   JOURNAL OF PAIN

Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain

(2012) I.A. Napier et al.   NEUROPHARMACOLOGY

Nicotinic acetylcholine receptors: From basic science to therapeutics

(2012) Raymond Hurst et al.   PHARMACOLOGY & THERAPEUTICS

Conotoxins Targeting Neuronal Voltage-Gated Sodium Channel Subtypes: Potential Analgesics?

(2012) Oliver Knapp et al.   Toxins

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic

(2011) Joseph R. Holtman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure and Activity of α-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABABReceptor-coupled N-type Calcium Channels

(2011) Norelle L. Daly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord

(2011) Bruce Mesnage et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABABReceptor

(2011) Reena Halai et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Subtype-selective conopeptides targeted to nicotinic receptors:Concerted discovery and biomedical applications

(2010) Baldomero M Olivera et al.   Channels

Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice

(2010) Brid Callaghan et al.   Channels

Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing

(2010) Arturo Andrade et al.   NATURE NEUROSCIENCE

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

(2010) BaoXi Gao et al.   PAIN

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain

(2010) Harry Klimis et al.   PAIN

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor

(2009) Reena Halai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Neuroimaging Studies Have Challenged Us to Rethink: Is Chronic Pain a Disease?

(2009) Irene Tracey et al.   JOURNAL OF PAIN

Dilemmas in Chronic/Persistent Pain Management

(2008) Warren A Katz et al.   AMERICAN JOURNAL OF THERAPEUTICS

Molecular modeling of the α9α10 nicotinic acetylcholine receptor subtype

(2008) Edwin G. Pérez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Overview of Non-neuronal Cholinergic Systems and Their Biological Significance

(2008) Koichiro Kawashima et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells

(2008) Jee-Hyun Kong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY