The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders

CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway

(2021) Xiangyuan Cao et al.   INFLAMMATION

MeCP2: The Genetic Driver of Rett Syndrome Epigenetics

(2021) Katrina V. Good et al.   Frontiers in Genetics

Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury

(2021) Mingkuan Lin et al.   PLoS One

Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupα7) Nicotinic Receptor Linked to Neuropsychiatric Disorders

(2021) Danlin Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients

(2021) Alice Courties et al.   Scientific Reports

The immunology of sepsis

(2021) Tom van der Poll et al.   IMMUNITY

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology

(2021) Maria Rosaria Tropea et al.   PROGRESS IN NEUROBIOLOGY

COVID-19 and the nicotinic cholinergic system

(2020) Konstantinos Farsalinos et al.   EUROPEAN RESPIRATORY JOURNAL

COVID-19 and Smoking. Is Nicotine the Hidden Link?

(2020) Patrizia Russo et al.   EUROPEAN RESPIRATORY JOURNAL

CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro

(2020) Theresa W. Chan et al.   INFLAMMATION RESEARCH

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

The role of the non‐neuronal cholinergic system in inflammation and degradation processes in osteoarthritis

(2020) Alice Courties et al.   Arthritis & Rheumatology

Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm

(2020) Jesus Gonzalez-Rubio et al.   Frontiers in Immunology

Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

(2020) Rashmi Gamage et al.   Frontiers in Cellular Neuroscience

CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease

(2020) Kinga Szigeti et al.   EBioMedicine

iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease

(2020) Ivanna Ihnatovych et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors

(2020) Susanna Pucci et al.   PHARMACOLOGICAL RESEARCH

Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis

(2020) Ildernandes Vieira-Alves et al.   Frontiers in Physiology

Modulation of the extraneuronal cholinergic system on main innate response leukocytes

(2019) Covantes-Rosales Carlos Eduardo et al.   JOURNAL OF NEUROIMMUNOLOGY

iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context

(2019) Ivanna Ihnatovych et al.   Translational Psychiatry

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

(2019) Matías Lasala et al.   Frontiers in Cellular Neuroscience

Association of a functional polymorphism in the CHRFAM7A gene with inflammatory response mediators and neuropathic pain after spinal cord injury

(2019) Wan Huang et al.   JOURNAL OF NEUROTRAUMA

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response

(2019) Todd W. Costantini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway

(2019) Annalisa Maroli et al.   JOURNAL OF NEUROIMMUNOLOGY

Global proteomic profiling of the uniquely human CHRFAM7A gene in transgenic mouse brain

(2019) Yu Jiang et al.   GENE

Regulation of inflammatory gene expression in macrophages by epithelial-stromal interaction 1 (Epsti1)

(2018) Young-Hoon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

(2018) Michele Zoli et al.   Current Neuropharmacology

A human-specific, truncated α7 nicotinic receptor subunit assembles with full-length α7 and forms functional receptors with different stoichiometries

(2018) Matías Lasala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the α7-nicotinic subunit with its human-specific duplicated dupα7 isoform in mammalian cells: Relevance in human inflammatory responses

(2018) María C Maldifassi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment

(2018) Sunil V. Kalmady et al.   JOURNAL OF NEURAL TRANSMISSION

Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors

(2018) Nadine Kabbani et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment

(2018) Cinzia Cameli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ordered Subset Analysis of Copy Number Variation Association with Age at Onset of Alzheimer's Disease

(2018) Kinga Szigeti et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroimmune Communication in Health and Disease

(2018) Colin Reardon et al.   PHYSIOLOGICAL REVIEWS

CHRFAM7A alters binding to the neuronal alpha-7 nicotinic acetylcholine receptor

(2018) Theresa Chan et al.   NEUROSCIENCE LETTERS

Alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease

(2018) Kai-Ge Ma et al.   NEUROPEPTIDES

Anti-tumoral activity of the human-specific duplicated form of α7-nicotinic receptor subunit in tobacco-induced lung cancer progression

(2018) José Luis Cedillo et al.   LUNG CANCER

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

(2017) Arik J. Hone et al.   FEBS LETTERS

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

(2017) Hiral Patel et al.   Journal of Neuroinflammation

Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation

(2017) Norikazu Kiguchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cholinergic modulation of the immune system presents new approaches for treating inflammation

(2017) Donald B. Hoover   PHARMACOLOGY & THERAPEUTICS

Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers

(2017) Anna Bordas et al.   Oncotarget

A G protein-coupled α7 nicotinic receptor regulates signaling and TNF-α release in microglia

(2017) Justin R. King et al.   FEBS Open Bio

15q13.3 duplication in two patients with childhood-onset schizophrenia

(2016) Dale Zhou et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders

(2016) Hans O. Kalkman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NLRP3 Is Involved in Ischemia/Reperfusion Injury

(2016) Zhiliang Guo et al.   CNS & Neurological Disorders-Drug Targets

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline

(2016) Elizabeth C. Ballinger et al.   NEURON

nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives

(2016) Vinay Parikh et al.   SCHIZOPHRENIA RESEARCH

Analysis ofCHRNA7rare variants in autism spectrum disorder susceptibility

(2015) Elena Bacchelli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CHRNA7andCHRFAM7AmRNAs: Co-Localized and Their Expression Levels Altered in the Postmortem Dorsolateral Prefrontal Cortex in Major Psychiatric Disorders

(2015) Yasuto Kunii et al.   AMERICAN JOURNAL OF PSYCHIATRY

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

(2015) Javier Egea et al.   BIOCHEMICAL PHARMACOLOGY

Alpha7 nicotinic receptors as therapeutic targets for Parkinson's disease

(2015) Maryka Quik et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of multiple putative risk alleles within the 15q13.3 region for genetic generalized epilepsy

(2015) John A. Damiano et al.   EPILEPSY RESEARCH

CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS

(2015) Xitong Dang et al.   FASEB JOURNAL

Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder

(2015) Félix M. Ramos et al.   JOURNAL OF NEUROVIROLOGY

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(2015) Todd Costantini et al.   MOLECULAR MEDICINE

Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case–Control Study

(2015) Birgitte Bertelsen et al.   NEUROMOLECULAR MEDICINE

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

(2015) Melissa L. Sinkus et al.   NEUROPHARMACOLOGY

Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease

(2015) Yuan Liu et al.   NEUROPHARMACOLOGY

Nicotinic acetylcholine receptors in human genetic disease

(2014) Christian P. Schaaf   GENETICS IN MEDICINE

Inhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity

(2014) Miroslav Pohanka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Usefulness of α7 Nicotinic Receptor Messenger RNA Levels in Peripheral Blood Mononuclear Cells as a Marker for Cholinergic Antiinflammatory Pathway Activity in Septic Patients: Results of a Pilot Study

(2014) José L. Cedillo et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting the α7 nicotinic acetylcholine receptor to prevent progressive dementia and improve cognition in adults with Down's syndrome

(2014) Stephen I. Deutsch et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Microduplication of 15q13.3 and Xq21.31 in a family with tourette syndrome and comorbidities

(2013) Linea Melchior et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

On the Interaction of β-Amyloid Peptides and α7-Nicotinic Acetylcholine Receptors in Alzheimer’s Disease

(2013) Murat Oz et al.   Current Alzheimer Research

Genetic Variations in CHRNA7 or CHRFAM7 and Susceptibility to Dementia

(2013) Monica Neri et al.   CURRENT DRUG TARGETS

Association Study of the 2-bp Deletion Polymorphism in Exon 6 of the CHRFAM7A Gene with Idiopathic Generalized Epilepsy

(2013) Agata Rozycka et al.   DNA AND CELL BIOLOGY

Original article A transcript coding for a partially duplicated form of α7 nicotinic acetylcholine receptor is absent from the CD4 + T-lymphocytes of patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)

(2013) Agata Rozycka et al.   FOLIA NEUROPATHOLOGICA

Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia

(2013) A L Guillozet-Bongaarts et al.   MOLECULAR PSYCHIATRY

Copy number variants are frequent in genetic generalized epilepsy with intellectual disability

(2013) S. A. Mullen et al.   NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Stoichiometry for activation of neuronal  7 nicotinic receptors

(2013) N. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurocognitive endophenotypes in schizophrenia: Modulation by nicotinic receptor systems

(2013) Kristen M. Mackowick et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study

(2012) Shanker Swaminathan et al.   Current Alzheimer Research

Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating

(2012) Rachel H Flomen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia

(2012) Merouane Bencherif et al.   MEDICAL HYPOTHESES

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(2012) Peder Olofsson et al.   MOLECULAR MEDICINE

Evolution of genetic and genomic features unique to the human lineage

(2012) Majesta O'Bleness et al.   NATURE REVIEWS GENETICS

Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals

(2012) Shanker Swaminathan et al.   PLoS One

Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3

(2011) Nigel M. Williams et al.   AMERICAN JOURNAL OF PSYCHIATRY

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

(2011) H. Rheinallt Parri et al.   BIOCHEMICAL PHARMACOLOGY

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

(2011) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Absence seizures with intellectual disability as a phenotype of the 15q13.3 microdeletion syndrome

(2011) Hiltrud Muhle et al.   EPILEPSIA

An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities

(2011) Erin B. Kaminsky et al.   GENETICS IN MEDICINE

15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain

(2011) Dag H. Yasui et al.   HUMAN MOLECULAR GENETICS

Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome

(2011) Makiko Meguro-Horike et al.   HUMAN MOLECULAR GENETICS

Up-regulation of the Neuronal Nicotinic Receptor α7 by HIV Glycoprotein 120

(2011) Leomar Y. Ballester et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A copy number variation morbidity map of developmental delay

(2011) Gregory M Cooper et al.   NATURE GENETICS

Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia

(2011) Sarah H. Stephens et al.   PSYCHIATRIC GENETICS

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Delineation of 15q13.3 microdeletions

(2010) A Masurel-Paulet et al.   CLINICAL GENETICS

Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: benign or pathological?

(2010) Przemyslaw Szafranski et al.   HUMAN MUTATION

Function of Partially Duplicated Human α7 Nicotinic Receptor SubunitCHRFAM7AGene

(2010) Ana M. de Lucas-Cerrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS

(2010) Roberta Benfante et al.   JOURNAL OF NEUROIMMUNOLOGY

Genetic Association Study of the Alpha 7 Nicotinic Receptor (CHRNA7) with the Development of Schizophrenia and Bipolar Disorder in Korean Population

(2010) Eun-Jeong Joo et al.   Psychiatry Investigation

The structural basis of function in Cys-loop receptors

(2010) Andrew J. Thompson et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Genome-Wide Copy Number Variation in Epilepsy: Novel Susceptibility Loci in Idiopathic Generalized and Focal Epilepsies

(2010) Heather C. Mefford et al.   PLoS Genetics

The α7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation

(2009) Marjolein A. Van Maanen et al.   ARTHRITIS AND RHEUMATISM

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

(2009) Marjolein A. van Maanen et al.   ARTHRITIS AND RHEUMATISM

A 2-base pair deletion polymorphism in the partial duplication of the α7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia

(2009) Melissa L. Sinkus et al.   BRAIN RESEARCH

Cognitive Improvement by Activation of α7 Nicotinic Acetylcholine Receptors: From Animal Models to Human Pathophysiology

(2009) Morten Thomsen et al.   CURRENT PHARMACEUTICAL DESIGN

Association between a Genetic Variant of the Alpha-7 Nicotinic Acetylcholine Receptor Subunit and Four Types of Dementia

(2009) Ágnes Fehér et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance

(2009) L. M. Dibbens et al.   HUMAN MOLECULAR GENETICS

CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance

(2009) Nadine Petrovsky et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Deletion of the  7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease

(2009) G. Dziewczapolski et al.   JOURNAL OF NEUROSCIENCE

15q13.3 microdeletions increase risk of idiopathic generalized epilepsy

(2009) Ingo Helbig et al.   NATURE GENETICS

Association of the 5′-upstream regulatory region of the α7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia

(2009) Sarah H. Stephens et al.   SCHIZOPHRENIA RESEARCH

Structural Variation of Chromosomes in Autism Spectrum Disorder

(2008) Christian R. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics

(2008) Alan R. Sanders et al.   AMERICAN JOURNAL OF PSYCHIATRY

Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

(2008) Valentin A. Pavlov et al.   BRAIN BEHAVIOR AND IMMUNITY

The copy number variant involving part of the α7 nicotinic receptor gene contains a polymorphic inversion

(2008) Rachel H Flomen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Differentiating nicotine- versus schizophrenia-associated decreases of the α7 nicotinic acetylcholine receptor transcript, CHRFAM7A, in peripheral blood lymphocytes

(2008) Emily G. Severance et al.   JOURNAL OF NEURAL TRANSMISSION

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer Therapy

(2008) Pingfang Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE

Large recurrent microdeletions associated with schizophrenia

(2008) Hreinn Stefansson et al.   NATURE

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY