Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

(2015) Alex I Chernyavsky et al.   BMC CANCER

Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

(2014) Kalyana B. Akondi et al.   CHEMICAL REVIEWS

Alpha9Alpha10 Nicotinic Acetylcholine Receptors as Target for the Treatment of Chronic Pain

(2014) Alessandra Bufalo et al.   CURRENT PHARMACEUTICAL DESIGN

α9-Nicotinic Acetylcholine Receptors Contribute to the Maintenance of Chronic Mechanical Hyperalgesia, but Not Thermal or Mechanical Allodynia

(2014) Sarasa Mohammadi et al.   Molecular Pain

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

(2014) Lorenzo Di Cesare Mannelli et al.   PAIN

Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

(2013) Bianca J. van Lierop et al.   ACS Chemical Biology

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Intrathecal Ziconotide: A Review of Its Use in Patients with Chronic Pain Refractory to Other Systemic or Intrathecal Analgesics

(2013) Mark Sanford   CNS DRUGS

Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors

(2013) Alain R Simard et al.   IMMUNOLOGY AND CELL BIOLOGY

Identification of CaV channel types expressed in muscle afferent neurons

(2013) Renuka Ramachandra et al.   JOURNAL OF NEUROPHYSIOLOGY

Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes

(2013) Robin N. Beech et al.   PARASITOLOGY INTERNATIONAL

A Novel Inhibitor of α9α10 Nicotinic Acetylcholine Receptors from Conus vexillum Delineates a New Conotoxin Superfamily

(2013) Sulan Luo et al.   PLoS One

Novel Small Molecule α9α10 Nicotinic Receptor Antagonist Prevents and Reverses Chemotherapy-Evoked Neuropathic Pain in Rats

(2012) Elzbieta P. Wala et al.   ANESTHESIA AND ANALGESIA

Expression, renaturation and biological activity of recombinant conotoxin GeXIVAWT

(2012) Bingmiao Gao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins

(2012) Hartmut Cuny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Phylogeny, Classification and Evolution of Conopeptides

(2012) N. Puillandre et al.   JOURNAL OF MOLECULAR EVOLUTION

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

Deep Venomics Reveals the Mechanism for Expanded Peptide Diversity in Cone Snail Venom

(2012) Sébastien Dutertre et al.   MOLECULAR & CELLULAR PROTEOMICS

Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor

(2012) M. Lipovsek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain

(2011) Guangrong Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

The novel small molecule α9α10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic

(2011) Joseph R. Holtman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors

(2011) Luca Pucci et al.   FASEB JOURNAL

Structure and Activity of α-Conotoxin PeIA at Nicotinic Acetylcholine Receptor Subtypes and GABABReceptor-coupled N-type Calcium Channels

(2011) Norelle L. Daly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain III regulates N-type (CaV2.2) calcium channel closing kinetics

(2011) Viktor Yarotskyy et al.   JOURNAL OF NEUROPHYSIOLOGY

The efferent medial olivocochlear-hair cell synapse

(2011) Ana Belén Elgoyhen et al.   JOURNAL OF PHYSIOLOGY-PARIS

Naturally Occurring Variants of Human Α9 Nicotinic Receptor Differentially Affect Bronchial Cell Proliferation and Transformation

(2011) Anna Chikova et al.   PLoS One

Atypical α-Conotoxin LtIA fromConus litteratusTargets a Novel Microsite of the α3β2 Nicotinic Receptor

(2010) Sulan Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of  9-Containing Cholinergic Nicotinic Receptors in the Rat Adrenal Medulla: Implication in Stress-Induced Functional Plasticity

(2010) C. Colomer et al.   JOURNAL OF NEUROSCIENCE

Evolution of Conus peptide toxins: Analysis of Conus californicus Reeve, 1844

(2010) Jason S. Biggs et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Persistent inflammation alters the density and distribution of voltage-activated calcium channels in subpopulations of rat cutaneous DRG neurons

(2010) Shao-Gang Lu et al.   PAIN

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain

(2010) Harry Klimis et al.   PAIN

PROMOTIF-A program to identify and analyze structural motifs in proteins

(2010) E. Gail Hutchinson et al.   PROTEIN SCIENCE

Conopeptide characterization and classifications: An analysis using ConoServer

(2010) Quentin Kaas et al.   TOXICON

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

Novel αD-Conopeptides and Their Precursors Identified by cDNA Cloning Define the D-Conotoxin Superfamily†‡

(2009) Marion L. Loughnan et al.   BIOCHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS

(2009) Jasmine Davis et al.   PEPTIDES

α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding Residues

(2008) Michael Ellison et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of the sensory neuron specific regulatory region for the mouse gene encoding the voltage-gated sodium channel NaV1.8

(2008) Henry L. Puhl III et al.   JOURNAL OF NEUROCHEMISTRY

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Characterization of a novel ψ-conotoxin from Conus parius Reeve

(2007) Arturo O. Lluisma et al.   TOXICON