Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs

Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

(2016) Rafia Mir et al.   CURRENT PHARMACEUTICAL DESIGN

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

(2016) Saeed Sadigh-Eteghad et al.   JOURNAL OF NEURAL TRANSMISSION

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

(2016) Bo Lin et al.   Scientific Reports

The Structural Features of α-Conotoxin Specifically Target Different Isoforms of Nicotinic Acetylcholine Receptors

(2015) Rui-Jie Wu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Key Residues in the Nicotinic Acetylcholine Receptor β2 Subunit Contribute to α-Conotoxin LvIA Binding

(2015) Dongting Zhangsun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

(2015) Shuo Wang et al.   Marine Drugs

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

(2015) Rilei Yu et al.   Scientific Reports

Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

(2014) Kalyana B. Akondi et al.   CHEMICAL REVIEWS

A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors

(2014) Sulan Luo et al.   FASEB JOURNAL

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

(2014) Eline Lebbe et al.   Marine Drugs

Positional Scanning Mutagenesis of α-Conotoxin PeIA Identifies Critical Residues That Confer Potency and Selectivity for α6/α3β2β3 and α3β2 Nicotinic Acetylcholine Receptors

(2013) Arik J. Hone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors

(2013) Anton A. Grishin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

(2013) Rilei Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

Micromechanical measurement of AChBP binding for label-free drug discovery

(2011) Koutilya Buchapudi et al.   ANALYST

Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors

(2011) Luca Pucci et al.   FASEB JOURNAL

Effects of Cyclization on Stability, Structure, and Activity of α-Conotoxin RgIA at the α9α10 Nicotinic Acetylcholine Receptor and GABABReceptor

(2011) Reena Halai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds

(2011) Igor E. Kasheverov et al.   Marine Drugs

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insight in nAChR subtype selectivity from AChBP crystal structures

(2009) Prakash Rucktooa et al.   BIOCHEMICAL PHARMACOLOGY

Nicotinic acetylcholine receptors at atomic resolution

(2009) Victor Tsetlin et al.   CURRENT OPINION IN PHARMACOLOGY

Naturally Occurring and Synthetic Peptides Acting on Nicotinic Acetylcholine Receptors

(2009) Igor Kasheverov et al.   CURRENT PHARMACEUTICAL DESIGN

Structural studies of conotoxins

(2009) Norelle L. Daly et al.   IUBMB LIFE

Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor

(2009) Reena Halai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conotoxins: natural product drug leads

(2009) Reena Halai et al.   NATURAL PRODUCT REPORTS

Inhibition of Neuronal Nicotinic Acetylcholine Receptor Subtypes by α-Conotoxin GID and Analogues

(2008) Emma L. Millard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Engineering of Conotoxins: The Importance of Loop Size to α-Conotoxin Structure and Function

(2008) Ai-Hua Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding Residues

(2008) Michael Ellison et al.   JOURNAL OF MOLECULAR BIOLOGY