A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor

A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors

(2021) A. Sofia F. Oliveira et al.   BIOPHYSICAL JOURNAL

A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors

(2021) Teresa Minguez‐Viñas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor

(2021) Colleen M. Noviello et al.   CELL

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

(2021) Yuyang Lei et al.   CIRCULATION RESEARCH

Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins

(2021) Stephen N. Grant et al.   BIOPHYSICAL JOURNAL

Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor

(2021) Juan Facundo Chrestia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Could Small Neurotoxins-Peptides be Expressed during SARS-CoV-2 Infection?

(2021) Concetta Cafiero et al.   CURRENT GENOMICS

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 and Smoking. Is Nicotine the Hidden Link?

(2020) Patrizia Russo et al.   EUROPEAN RESPIRATORY JOURNAL

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

(2020) Roger L. Papke et al.   NEUROPHARMACOLOGY

Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications

(2020) Konstantinos Farsalinos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease

(2020) Alana F Ogata et al.   CLINICAL CHEMISTRY

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

(2020) Lorenzo Casalino et al.   ACS Central Science

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

(2020) Andrey V. Letarov et al.   BIOCHEMISTRY-MOSCOW

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

(2019) Matías Lasala et al.   Frontiers in Cellular Neuroscience

Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor

(2019) Catriona E. W. Blunt et al.   MOLECULAR PHARMACOLOGY

A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE

(2019) Jean-Rémi Godin et al.   BRAIN BEHAVIOR AND IMMUNITY

Flavonoids as positive allosteric modulators of α7 nicotinic receptors

(2019) Beatriz Elizabeth Nielsen et al.   NEUROPHARMACOLOGY

Molecular function of the novel α7β2 nicotinic receptor

(2018) Beatriz E. Nielsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel pharmacological activity of caffeine in the cholinergic system

(2018) Camila Fabiani et al.   NEUROPHARMACOLOGY

Acute lung injury is reduced by the α7nAChR agonist PNU-282987 through changes in the macrophage profile

(2017) Nathalia M. Pinheiro et al.   FASEB JOURNAL

Molecular function of α7 nicotinic receptors as drug targets

(2017) Cecilia Bouzat et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Distribution of Charged Amino Acid Residues and the Ca2+ Permeability of Nicotinic Acetylcholine Receptors: A Predictive Model

(2017) Sergio Fucile   Frontiers in Molecular Neuroscience

The current agonists and positive allosteric modulators of α 7 nAChR for CNS indications in clinical trials

(2017) Taoyi Yang et al.   Acta Pharmaceutica Sinica B

Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS

(2017) Karsten Hueffer et al.   Scientific Reports

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

(2016) Shenyan Gu et al.   NEURON

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

(2016) Natalia D. Andersen et al.   NEUROPHARMACOLOGY

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

(2015) Javier Egea et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric modulation of nicotinic acetylcholine receptors

(2015) Anna Chatzidaki et al.   BIOCHEMICAL PHARMACOLOGY

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

(2015) Roger L. Papke et al.   NEUROPHARMACOLOGY

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

(2015) Radovan Spurny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The therapeutic promise of positive allosteric modulation of nicotinic receptors

(2014) Victor V. Uteshev   EUROPEAN JOURNAL OF PHARMACOLOGY

Nicotine Inhibits Microglial Proliferation and Is Neuroprotective in Global Ischemia Rats

(2014) Yan-Zhong Guan et al.   MOLECULAR NEUROBIOLOGY

Are nicotinic acetylcholine receptors coupled to G proteins?

(2013) Nadine Kabbani et al.   BIOESSAYS

Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor

(2013) Kinga Chojnacka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stoichiometry for activation of neuronal  7 nicotinic receptors

(2013) N. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein

(2010) Marijke Brams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

(2009) Ryan E Hibbs et al.   EMBO JOURNAL

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

(2008) C. Bouzat et al.   JOURNAL OF NEUROSCIENCE

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(2008) William Parrish et al.   MOLECULAR MEDICINE

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic receptors, allosteric proteins and medicine

(2008) Jean-Pierre Changeux et al.   TRENDS IN MOLECULAR MEDICINE