Identification of a Novel O-Conotoxin Reveals an Unusual and Potent Inhibitor of the Human α9α10 Nicotinic Acetylcholine Receptor

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype

(2017) Dongting Zhangsun et al.   NEUROPHARMACOLOGY

Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

(2016) Rafia Mir et al.   CURRENT PHARMACEUTICAL DESIGN

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors

(2015) Sean B. Christensen et al.   BIOCHEMICAL PHARMACOLOGY

The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature

(2015) Lynn R. Webster   PAIN MEDICINE

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

(2015) Sulan Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors

(2015) Shaoqiong Xu et al.   Scientific Reports

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

(2015) Sarasa Mohammadi et al.   Toxins

Alpha9Alpha10 Nicotinic Acetylcholine Receptors as Target for the Treatment of Chronic Pain

(2014) Alessandra Bufalo et al.   CURRENT PHARMACEUTICAL DESIGN

Identification of Two Novel O2-Conotoxins from Conus generalis

(2014) Shaoqiong Xu et al.   International Journal of Peptide Research and Therapeutics

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism

(2014) L. Chen et al.   SCIENCE

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

(2014) Sébastien Dutertre et al.   Nature Communications

Differential modulation of EAE by α9*- and β2*-nicotinic acetylcholine receptors

(2013) Alain R Simard et al.   IMMUNOLOGY AND CELL BIOLOGY

Various Conotoxin Diversifications Revealed by a Venomic Study ofConus flavidus

(2013) Aiping Lu et al.   MOLECULAR & CELLULAR PROTEOMICS

Biodiversity of Cone Snails and Other Venomous Marine Gastropods: Evolutionary Success Through Neuropharmacology

(2013) Baldomero M. Olivera et al.   Annual Review of Animal Biosciences

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

Conotoxins that Confer Therapeutic Possibilities

(2012) Magbubah Essack et al.   Marine Drugs

Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (CaV2.2) calcium channels

(2011) David J Adams et al.   BRITISH JOURNAL OF PHARMACOLOGY

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

(2011) Q. Kaas et al.   NUCLEIC ACIDS RESEARCH

Overexpression and Activation of the α9-Nicotinic Receptor During Tumorigenesis in Human Breast Epithelial Cells

(2010) Chia-Hwa Lee et al.   JNCI-Journal of the National Cancer Institute

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?

(2009) Ana Belén Elgoyhen et al.   BIOCHEMICAL PHARMACOLOGY

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors

(2009) Craig S. Walker et al.   CURRENT BIOLOGY

TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom

(2009) Loïc Quinton et al.   Journal of Proteomics

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE