Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors

Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors

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Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

(2018) Richard M. Walsh et al.   NATURE

Nicotinic acetylcholine receptors in neuropathic and inflammatory pain

(2017) Arik J. Hone et al.   FEBS LETTERS

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function

(2017) Juan Carlos Boffi et al.   MOLECULAR PHARMACOLOGY

Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons

(2017) Mahsa Sadeghi et al.   NEUROPHARMACOLOGY

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

(2017) Haylie K. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

(2017) Sean B. Christensen et al.   Frontiers in Cellular Neuroscience

The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes

(2017) Manyu Xu et al.   Protein & Cell

Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor

(2017) Nikita Abraham et al.   Scientific Reports

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer

(2016) Nikolaos Kouvatsos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

(2016) Bo Lin et al.   Scientific Reports

Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning

(2015) Chad W. Hopkins et al.   Journal of Chemical Theory and Computation

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release

(2015) Andreas Hecker et al.   JOURNAL OF IMMUNOLOGY

Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment

(2015) Andrew G Engel et al.   LANCET NEUROLOGY

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs

(2015) Yves Bourne et al.   STRUCTURE

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric-dependent action of the α-conotoxin, Vc1.1

(2014) Dinesh C. Indurthi et al.   BIOCHEMICAL PHARMACOLOGY

A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors

(2014) Sulan Luo et al.   FASEB JOURNAL

Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain

(2014) Marios Zouridakis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

α-Conotoxin RgIA protects against the development of nerve injury-induced chronic pain and prevents both neuronal and glial derangement

(2014) Lorenzo Di Cesare Mannelli et al.   PAIN

The Non-Neuronal Cholinergic System in Health and Disease

(2014) Janet Beckmann et al.   PHARMACOLOGY

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

(2013) Romelia Salomon-Ferrer et al.   Journal of Chemical Theory and Computation

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting Nicotinic Receptors for Parkinson's Disease Therapy

(2012) Maryka Quik et al.   CNS & Neurological Disorders-Drug Targets

Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA

(2012) Layla Azam et al.   JOURNAL OF NEUROCHEMISTRY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Creating an α7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein

(2011) Ákos Nemecz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist

(2011) Shu-Xing Li et al.   NATURE NEUROSCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

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Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors

(2009) Layla Azam et al.   ACTA PHARMACOLOGICA SINICA

The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?

(2009) Ana Belén Elgoyhen et al.   BIOCHEMICAL PHARMACOLOGY

Insight in nAChR subtype selectivity from AChBP crystal structures

(2009) Prakash Rucktooa et al.   BIOCHEMICAL PHARMACOLOGY

Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors

(2009) Victor Tsetlin et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacological approaches to the treatment of tinnitus

(2009) Ana B. Elgoyhen et al.   DRUG DISCOVERY TODAY

Scanning Mutagenesis of α-Conotoxin Vc1.1 Reveals Residues Crucial for Activity at the α9α10 Nicotinic Acetylcholine Receptor

(2009) Reena Halai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Molecular modeling of the α9α10 nicotinic acetylcholine receptor subtype

(2008) Edwin G. Pérez et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

The three-dimensional structure of the analgesic α-conotoxin, RgIA

(2008) Richard J. Clark et al.   FEBS LETTERS

α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding Residues

(2008) Michael Ellison et al.   JOURNAL OF MOLECULAR BIOLOGY

Analgesic  -Conotoxins Vc1.1 and Rg1A Inhibit N-Type Calcium Channels in Rat Sensory Neurons via GABAB Receptor Activation

(2008) B. Callaghan et al.   JOURNAL OF NEUROSCIENCE

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY