Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]

(2021) Zhiguo Li et al.   Marine Drugs

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

(2020) Pan Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB

(2020) Xincan Li et al.   Marine Drugs

The Impact of Plasma Protein Binding Characteristics and Unbound Concentration of Voriconazole on Its Adverse Drug Reactions

(2020) Zi-Qing-Yun Yuan et al.   Frontiers in Pharmacology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

(2020) Tian Jin et al.   JOURNAL OF NANOBIOTECHNOLOGY

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor

(2020) Xiao Li et al.   PHARMACOLOGY & THERAPEUTICS

Potential biomarkers for persistent and neuropathic pain therapy

(2019) Marco Sisignano et al.   PHARMACOLOGY & THERAPEUTICS

The α9α10 Nicotinic Acetylcholine Receptor Antagonist αO-Conotoxin GeXIVA[1,2] Alleviates and Reverses Chemotherapy-Induced Neuropathic Pain

(2019) Huanbai Wang et al.   Marine Drugs

DSPE-PEG Modification of α-Conotoxin TxID

(2019) Weinan Zhao et al.   Marine Drugs

Conotoxins: Chemistry and Biology

(2019) Ai-Hua Jin et al.   CHEMICAL REVIEWS

Effects of serum, enzyme, thiol, and forced degradation on the stabilities of αO-Conotoxin GeXIVA[1,2] and GeXIVA [1,4]

(2018) Shurun Yu et al.   Chemical Biology & Drug Design

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

(2018) Anroop Nair et al.   DRUG DEVELOPMENT RESEARCH

Discovery Methodology of Novel Conotoxins from Conus Species

(2018) Ying Fu et al.   Marine Drugs

The Polyanalgesic Consensus Conference (PACC): Recommendations on Intrathecal Drug Infusion Systems Best Practices and Guidelines

(2017) Timothy R. Deer et al.   NEUROMODULATION

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype

(2017) Dongting Zhangsun et al.   NEUROPHARMACOLOGY

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

(2017) Sean B. Christensen et al.   Frontiers in Cellular Neuroscience

Identification of a novel spinal nociceptive-motor gate control for Aδ pain stimuli in rats

(2017) Dvir Blivis et al.   eLife

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

The α9α10 nicotinic receptor antagonist α-conotoxin RgIA prevents neuropathic pain induced by oxaliplatin treatment

(2016) Alessandra Pacini et al.   EXPERIMENTAL NEUROLOGY

Anti-hypersensitive effect of intramuscular administration of αO-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic pain

(2016) Xiaodan Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuropathic Pain

(2016) Ralf Baron et al.   SEMINARS IN NEUROLOGY

Neuropathic Pain: Principles of Diagnosis and Treatment

(2015) Ian Gilron et al.   MAYO CLINIC PROCEEDINGS

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist

(2015) Sulan Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of Model‐based Methods to Characterize Exenatide‐loaded Double‐walled Microspheres: In vivo Release, Pharmacokinetic/Pharmacodynamic Model, and In Vitro and In Vivo Correlation

(2012) Xingang Li et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Translational PK–PD modeling in pain

(2012) Ashraf Yassen et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Bioavailability of Bioactive Peptides

(2011) Maira Segura-Campos et al.   FOOD REVIEWS INTERNATIONAL

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

(2009) J. Michael McIntosh et al.   BIOCHEMICAL PHARMACOLOGY