Up‐regulation of the human‐specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy

Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis

(2022) Tiankui Ma et al.   Frontiers in Immunology

CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway

(2021) Xiangyuan Cao et al.   INFLAMMATION

Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT

(2021) Margherita Sisto et al.   Biomolecules

Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2

(2021) Peter Stenvinkel et al.   Kidney International Reports

Chrysin Ameliorates Cyclosporine-A-Induced Renal Fibrosis by Inhibiting TGF-β1-Induced Epithelial–Mesenchymal Transition

(2021) Rohan Reddy Nagavally et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CHRFAM7A expression in mice increases resiliency after injury

(2021) Todd W. Costantini et al.   INFLAMMATION RESEARCH

TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1

(2020) Jie Su et al.   NATURE

Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-β-Smad Signaling Pathway

(2020) Hong Ding et al.   Molecular Therapy-Nucleic Acids

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway

(2020) Yuan Liao et al.   Drug Design Development and Therapy

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Transcriptional characteristics of activated macrophages

(2019) Victor Glanz et al.   CURRENT PHARMACEUTICAL DESIGN

Renal Inflammation and Fibrosis: A Double-edged Sword

(2019) Laurence M. Black et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway

(2019) Annalisa Maroli et al.   JOURNAL OF NEUROIMMUNOLOGY

Expression and localization analyses of the cholinergic anti-inflammatory pathway and α7nAchR in different tissues of rats with rheumatoid arthritis

(2019) Zhen Li et al.   ACTA HISTOCHEMICA

Global proteomic profiling of the uniquely human CHRFAM7A gene in transgenic mouse brain

(2019) Yu Jiang et al.   GENE

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment

(2018) Sunil V. Kalmady et al.   JOURNAL OF NEURAL TRANSMISSION

Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction

(2018) Ming Wu et al.   LABORATORY INVESTIGATION

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice

(2018) Sherehan M. Ibrahim et al.   Scientific Reports

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation

(2016) Agnieszka Loboda et al.   MEDIATORS OF INFLAMMATION

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Absence of nicotinic acetylcholine receptor α7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model

(2015) Luan D. Truong et al.   FASEB JOURNAL

CHRFAM7A: a human-specific α7-nicotinic acetylcholine receptor gene shows differential responsiveness of human intestinal epithelial cells to LPS

(2015) Xitong Dang et al.   FASEB JOURNAL

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(2015) Todd Costantini et al.   MOLECULAR MEDICINE

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

(2015) Melissa L. Sinkus et al.   NEUROPHARMACOLOGY

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHRFAM7A, a human-specific and partially duplicated α 7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury

(2014) Todd W. Costantini et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Potential approaches to reverse or repair renal fibrosis

(2014) Desiree Tampe et al.   Nature Reviews Nephrology

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

(2011) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Function of Partially Duplicated Human α7 Nicotinic Receptor SubunitCHRFAM7AGene

(2010) Ana M. de Lucas-Cerrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis

(2010) I. Idasiak-Piechocka et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

(2009) Robert L. Chevalier et al.   KIDNEY INTERNATIONAL

Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells

(2008) Kunal Rehani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH