Formation, immunomodulatory activities, and enhancement of glucosinolates and sulforaphane in broccoli sprouts: a review for maximizing the health benefits to human

Sulforaphane Inhibits Osteoclastogenesis via Suppression of the Autophagic Pathway

(2021) Tingting Luo et al.   MOLECULES

Dietary isothiocyanates inhibit cancer progression by modulation of epigenome

(2021) Madhumitha Kedhari Sundaram et al.   SEMINARS IN CANCER BIOLOGY

The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: a systematic review of human intervention trials

(2021) Tom Clifford et al.   MOLECULAR BIOLOGY REPORTS

Potential of Sulforaphane as a Natural Immune System Enhancer: A Review

(2021) Andrea Mahn et al.   MOLECULES

Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription

(2021) Rui Tang et al.   ACTA PHARMACOLOGICA SINICA

Sulforaphane: A review of its therapeutic potentials, advances in its nanodelivery, recent patents, and clinical trials

(2021) Bharti Mangla et al.   PHYTOTHERAPY RESEARCH

Effects of glucoraphanin-rich broccoli sprout extracts on sleep quality in healthy adults: An exploratory study

(2021) Masahiro Kikuchi et al.   Journal of Functional Foods

Factors Influencing Sulforaphane Content in Broccoli Sprouts and Subsequent Sulforaphane Extraction

(2021) Jan Tříska et al.   Foods

Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells

(2021) Xueqi Qu et al.   Biology-Basel

CaCl2-HCl electrolyzed water affects glucosinolate metabolism and improves the quality of broccoli sprouts

(2021) Cui Li et al.   FOOD RESEARCH INTERNATIONAL

Postharvest UV-B and UV-C radiation enhanced the biosynthesis of glucosinolates and isothiocyanates in Brassicaceae sprouts

(2021) Lorena Martínez-Zamora et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

(2021) Mirko Marino et al.   Frontiers in Nutrition

The effects of cruciferous vegetable‐enriched diets on drug metabolism: a systematic review and meta‐analysis of dietary intervention trials in humans

(2020) Shane K. Eagles et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Elevated CO2 improves glucosinolate metabolism and stimulates anticancer and anti-inflammatory properties of broccoli sprouts

(2020) Mohammed Almuhayawi et al.   FOOD CHEMISTRY

Microgreen nutrition, food safety, and shelf life: A review

(2020) Ellen R. Turner et al.   JOURNAL OF FOOD SCIENCE

Sulforaphane and its antioxidative effects in broccoli seeds and sprouts of different cultivars

(2020) Xingang Lv et al.   FOOD CHEMISTRY

Sulforaphane alter the microbiota and mitigate colitis severity on mice ulcerative colitis induced by DSS

(2020) Yan Zhang et al.   AMB Express

The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical

(2020) Ruheea Taskin Ruhee et al.   Antioxidants

Bioactive Compounds and Bioactivities of Brassica oleracea L. var. Italica Sprouts and Microgreens: An Updated Overview from a Nutraceutical Perspective

(2020) Thanh Ninh Le et al.   Plants-Basel

Protective Effect of Isothiocyanates from Cruciferous Vegetables on Breast Cancer: Epidemiological and Preclinical Perspectives

(2020) Suong N.T. Ngo et al.   Anti-Cancer Agents in Medicinal Chemistry

Selection and microencapsulation of myrosinase enzyme from broccoli sprouts of different varieties and characteristics evaluation

(2020) Xingang Lv et al.   JOURNAL OF FOOD PROCESS ENGINEERING

Studies on the development of vegetable-based powdered beverages – Effect of the composition and dispersing temperature on potential bioaccessibility of main low-molecular antioxidants and antioxidant properties

(2020) Justyna Bochnak-Niedźwiecka et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Calcium affects glucoraphanin metabolism in broccoli sprouts under ZnSO4 stress

(2020) Li Zhuang et al.   FOOD CHEMISTRY

Metabolomic analysis based on EESI-MS indicate blue LED light promotes aliphatic-glucosinolates biosynthesis in broccoli sprouts

(2020) Ahui Xue et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells

(2019) Linh Dieu Vuong et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Growth, Photosynthetic Pigments, Phenolic, Glucosinolates Content and Antioxidant Capacity of Broccoli Sprouts in Response to Nanoselenium Particles Supply

(2019) Simona Ioana VICAS et al.   Notulae Botanicae Horti Agrobotanici Cluj-Napoca

Dynamic variation of glucosinolates and isothiocyanates in broccoli sprouts during hydrolysis

(2019) Chaoqun Leng et al.   SCIENTIA HORTICULTURAE

Improvement of sulfur compounds in broccoli sprouts by methionine loaded polyvinyl alcohol-sodium alginate hydrogels for application in Kimchi

(2019) Sung Jin Park et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

EFFECT OF MANNITOL STRESS ON MORPHOLOGICAL, BIOCHEMICAL AND POLYPHENOL PARAMETERS IN BROCCOLI SPROUTS (BRASSICA OLERACEA VAR. ITALICA)

(2018) S. KIANI   APPLIED ECOLOGY AND ENVIRONMENTAL RESEARCH

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Glucoraphanin and sulforaphane evolution during juice preparation from broccoli sprouts

(2018) Cristiano Bello et al.   FOOD CHEMISTRY

Effect of slightly acidic electrolyzed water on bioactive compounds and morphology of broccoli sprouts

(2018) Lizhen Li et al.   FOOD RESEARCH INTERNATIONAL

Intensifying sulforaphane formation in broccoli sprouts by using other cruciferous sprouts additions

(2018) Hao Liang et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Calcium sulfate treatment enhances bioactive compounds and antioxidant capacity in broccoli sprouts during growth and storage

(2018) Liping Guo et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

The intrinsic quality of brassicaceous vegetables: How secondary plant metabolites are affected by genetic, environmental, and agronomic factors

(2018) Susanne Neugart et al.   SCIENTIA HORTICULTURAE

Slightly Acidic Electrolyzed Water Treatment Enhances the Main Bioactive Phytochemicals Content in Broccoli Sprouts via Changing Metabolism

(2018) Lizhen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Capsaicin and sulforaphane prevent experimental liver fibrosis via upregulation of peroxisome proliferator-activated receptor gamma and nuclear factor (erythroid-derived 2)-like 2

(2018) Edgar J. Mendivil et al.   Journal of Functional Foods

Pro- and anti-inflammatory effects of sulforaphane on placental cytokine production

(2018) Yuko Arita et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

UVA, UVB Light, and Methyl Jasmonate, Alone or Combined, Redirect the Biosynthesis of Glucosinolates, Phenolics, Carotenoids, and Chlorophylls in Broccoli Sprouts

(2017) Melissa Moreira-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Pressure Processing of Broccoli Sprouts: Influence on Bioactivation of Glucosinolates to Isothiocyanates

(2017) Anna Westphal et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Proteomic analysis of broccoli sprouts by iTRAQ in response to jasmonic acid

(2017) Liping Guo et al.   JOURNAL OF PLANT PHYSIOLOGY

Understanding of MYB Transcription Factors Involved in Glucosinolate Biosynthesis in Brassicaceae

(2017) et al.   MOLECULES

UVA, UVB Light Doses and Harvesting Time Differentially Tailor Glucosinolate and Phenolic Profiles in Broccoli Sprouts

(2017) Melissa Moreira-Rodríguez et al.   MOLECULES

Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreaticβ-Cells Function

(2017) Catalina Carrasco-Pozo et al.   Oxidative Medicine and Cellular Longevity

Broccoli and radish sprouts are safe and rich in bioactive phytochemicals

(2017) Nieves Baenas et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Improvement of broccoli sprouts ( Brassica oleracea L. var. italica) growth and quality by KCl seed priming and methyl jasmonate under salinity stress

(2017) Ismahen Hassini et al.   SCIENTIA HORTICULTURAE

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice

(2017) Katarzyna Socała et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bioactive compounds and bioactivities of germinated edible seeds and sprouts: An updated review

(2017) Ren-You Gan et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Sulforaphane, polyphenols and related anti-inflammatory and antioxidant activities changes of Egyptian broccoli during growth

(2017) Raef Shams et al.   Journal of Food Measurement and Characterization

Optimizing isothiocyanate formation during enzymatic glucosinolate breakdown by adjusting pH value, temperature and dilution in Brassica vegetables and Arabidopsis thaliana

(2017) Franziska S. Hanschen et al.   Scientific Reports

Microgreens: Production, shelf life, and bioactive components

(2016) Shabir Ahmad Mir et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Improvement of the nutraceutical quality of broccoli sprouts by elicitation

(2016) Fausta Natella et al.   FOOD CHEMISTRY

Effect of Se treatment on glucosinolate metabolism and health-promoting compounds in the broccoli sprouts of three cultivars

(2016) Ming Tian et al.   FOOD CHEMISTRY

Optimizing elicitation and seed priming to enrich broccoli and radish sprouts in glucosinolates

(2016) Nieves Baenas et al.   FOOD CHEMISTRY

The effect of the germination temperature on the phytochemical content of broccoli and rocket sprouts

(2016) Lucia Ragusa et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Optimisation of enzymatic production of sulforaphane in broccoli sprouts and their total antioxidant activity at different growth and storage days

(2016) Ming Tian et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

(2016) Vicente Hernández-Rabaza et al.   Journal of Neuroinflammation

Cloning of genes related to aliphatic glucosinolate metabolism and the mechanism of sulforaphane accumulation in broccoli sprouts under jasmonic acid treatment

(2016) Liping Guo et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages

(2016) Ye Won An et al.   NEUROBIOLOGY OF AGING

iTRAQ - based proteomic and physiological analyses of broccoli sprouts in response to the stresses of heat, hypoxia and heat plus hypoxia

(2016) Liping Guo et al.   PLANT AND SOIL

Micro-scale vegetable production and the rise of microgreens

(2016) Marios C. Kyriacou et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Effects of CaCl2 on the metabolism of glucosinolates and the formation of isothiocyanates as well as the antioxidant capacity of broccoli sprouts

(2016) Runqiang Yang et al.   Journal of Functional Foods

Heat and hypoxia stresses enhance the accumulation of aliphatic glucosinolates and sulforaphane in broccoli sprouts

(2015) Liping Guo et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Cell-based screening assay for anti-inflammatory activity of bioactive compounds

(2015) Kees Meijer et al.   FOOD CHEMISTRY

Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway

(2015) TIANJIE QI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of Sulforaphane on NOD2 via NF-κB: implications for Crohn’s disease

(2015) Danielle L Folkard et al.   Journal of Inflammation-London

Comparison of Glucosinolate Profiles in Different Tissues of Nine Brassica Crops

(2015) Shiva Bhandari et al.   MOLECULES

Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior

(2015) Brigitte E. Townsend et al.   NUTRITIONAL NEUROSCIENCE

Evaluating the impact of sprouting conditions on the glucosinolate content of Brassica oleracea sprouts

(2015) A.P. Vale et al.   PHYTOCHEMISTRY

Effect of refrigerated storage on the bioactive compounds and microbial quality of Brassica oleraceae sprouts

(2015) A.P. Vale et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells

(2015) Rahul Checker et al.   Journal of Functional Foods

Enhancement of glucosinolate and sulforaphane formation of broccoli sprouts by zinc sulphate via its stress effect

(2015) Runqiang Yang et al.   Journal of Functional Foods

Calcium mitigates the stress caused by ZnSO4 as a sulphur fertilizer and enhances the sulforaphane formation of broccoli sprouts

(2015) Runqiang Yang et al.   RSC Advances

A review of phytochemistry, metabolite changes, and medicinal uses of the common food mung bean and its sprouts (Vigna radiata)

(2014) Dongyan Tang et al.   Chemistry Central Journal

Impact of selenium supply on Se-methylselenocysteine and glucosinolate accumulation in selenium-biofortified Brassica sprouts

(2014) Fabricio William Ávila et al.   FOOD CHEMISTRY

Biotic Elicitors Effectively Increase the Glucosinolates Content in Brassicaceae Sprouts

(2014) Nieves Baenas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of 2, 4-epibrassinolide on main health-promoting compounds in broccoli sprouts

(2014) Rongfang Guo et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Food security and sustainable intensification

(2014) H. C. J. Godfray et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs

(2014) Liping Guo et al.   Journal of Functional Foods

Stability of sulforaphane for topical formulation

(2013) Stephen J. Franklin et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Response surface optimization and identification of isothiocyanates produced from broccoli sprouts

(2013) Qianghui Guo et al.   FOOD CHEMISTRY

Comparison of bioactive phytochemical content and release of isothiocyanates in selected brassica sprouts

(2013) Gina Rosalinda De Nicola et al.   FOOD CHEMISTRY

Inhibition of nitric oxide production corresponds to the sulforaphane content in Korean sheperd’s purse (Capsella bursa-pastoris) and related species in BV-2 cell

(2013) Jinyoung Hur et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Biochemical composition of broccoli seeds and sprouts at different stages of seedling development

(2013) Jaime López-Cervantes et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Effect of NaCl stress on health-promoting compounds and antioxidant activity in the sprouts of three broccoli cultivars

(2013) Liping Guo et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Effect of NaCl treatments on glucosinolate metabolism in broccoli sprouts

(2013) Rong-fang Guo et al.   Journal of Zhejiang University-SCIENCE B

Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention

(2013) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermally Induced Degradation of Sulfur-Containing Aliphatic Glucosinolates in Broccoli Sprouts (Brassica oleracea var. italica) and Model Systems

(2012) Franziska S. Hanschen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Selecting Sprouts of Brassicaceae for Optimum Phytochemical Composition

(2012) Nieves Baenas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Histone Deacetylase 3 Mediates Allergic Skin Inflammation by Regulating Expression of MCP1 Protein

(2012) Youngmi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform

(2012) Michael Dalgaard Mikkelsen et al.   METABOLIC ENGINEERING

Glucosinolate structures in evolution

(2012) Niels Agerbirk et al.   PHYTOCHEMISTRY

UV-B Irradiation Changes Specifically the Secondary Metabolite Profile in Broccoli Sprouts: Induced Signaling Overlaps with Defense Response to Biotic Stressors

(2012) Inga Mewis et al.   PLANT AND CELL PHYSIOLOGY

Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial

(2012) Parvin Mirmiran et al.   Journal of Functional Foods

Sucrose enhances the accumulation of anthocyanins and glucosinolates in broccoli sprouts

(2011) Rongfang Guo et al.   FOOD CHEMISTRY

Improving the phytochemical composition of broccoli sprouts by elicitation

(2011) Santiago Pérez-Balibrea et al.   FOOD CHEMISTRY

Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake

(2011) Jaouad Bouayed et al.   FOOD CHEMISTRY

Physiological and Biochemical Metabolism of Germinating Broccoli Seeds and Sprouts

(2011) Yingjuan Gu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory potential of allyl-isothiocyanate - role of Nrf2, NF-κB and microRNA-155

(2011) Anika Eva Wagner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design

(2011) John D. Clarke et al.   PHARMACOLOGICAL RESEARCH

Metabolic Engineering inNicotiana benthamianaReveals Key Enzyme Functions inArabidopsisIndole Glucosinolate Modification

(2011) Marina Pfalz et al.   PLANT CELL

Effects of broccoli sprouts intake on oxidative stress, inflammation, microalbuminuria and platelet function in human volunteers: a cross-over study

(2011) E. Munters et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Effect of sucrose and mannitol on the accumulation of health-promoting compounds and the activity of metabolic enzymes in broccoli sprouts

(2011) Rongfang Guo et al.   SCIENTIA HORTICULTURAE

Glucosinolates fortification of cruciferous sprouts by sulphur supplementation during cultivation to enhance anti-cancer activity

(2010) Rakesh Mohan Kestwal et al.   FOOD CHEMISTRY

Genotypic effects on the phytochemical quality of seeds and sprouts from commercial broccoli cultivars

(2010) Santiago Pérez-Balibrea et al.   FOOD CHEMISTRY

Key Role of Fe2+in Epithiospecifier Protein Activity

(2010) David J. Williams et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cellular and subcellular localization of flavin-monooxygenases involved in glucosinolate biosynthesis

(2010) Jing Li et al.   JOURNAL OF EXPERIMENTAL BOTANY

Glucosinolates in Broccoli Sprouts (Brassica oleracea var. italica) as Conditioned by Sulphate Supply during Germination

(2010) Santiago Pérez-Balibrea et al.   JOURNAL OF FOOD SCIENCE

Electrophilic tuning of the chemoprotective natural product sulforaphane

(2010) Y.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of glucosinolates – gene discovery and beyond

(2010) Ida E. Sønderby et al.   TRENDS IN PLANT SCIENCE

Time dependence of bioactive compounds and antioxidant capacity during germination of different cultivars of broccoli and radish seeds

(2009) Cristina Martinez-Villaluenga et al.   FOOD CHEMISTRY

Sulforaphane Suppresses Oligomerization of TLR4 in a Thiol-Dependent Manner

(2009) Hyung Sun Youn et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Influence of light on health-promoting phytochemicals of broccoli sprouts

(2008) Santiago Pérez-Balibrea et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

The Genetic Basis of Constitutive and Herbivore-Induced ESP-Independent Nitrile Formation in Arabidopsis

(2008) M. Burow et al.   PLANT PHYSIOLOGY

Genotype, Age, Tissue, and Environment Regulate the Structural Outcome of Glucosinolate Activation

(2008) A. M. Wentzell et al.   PLANT PHYSIOLOGY

Subclade of Flavin-Monooxygenases Involved in Aliphatic Glucosinolate Biosynthesis

(2008) J. Li et al.   PLANT PHYSIOLOGY

Towards engineering glucosinolates into non-cruciferous plants

(2008) Fernando Geu-Flores et al.   PLANTA